Effects of Aronia melanocarpa Extracts on Menopause Symptoms in Ovariectomized Rats

강아람,; 정경임,; 김미향,

doi:10.3746/jkfn.2018.47.12.1217

Cited by 3 publications

(2 citation statements)

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“…There are some data concerning the beneficial effects of Aronia melanocarpa extracts on bone mineral density and lipid profile in rats with OVX-induced estrogen deficit. [8] Grape powder, which is also rich in anthocyanins and quercetin, was able to improve the anxiety behavior in OVX rats. [18] In this experiment, we aimed to highlight the effects of AMFJ, applied at two different doses, on rat behavior in a model of ovariectomy-induced estrogen deficit.…”

Section: Discussionmentioning

confidence: 98%

“…[6,7] There are data that Aronia melanocarpa hot water extracts are able to antagonize the consequences of OVX-induced estrogen deficit on lipid profile and osteogenesis. [8] Previous experiments have demonstrated that Aronia melanocarpa fruit juice (AMFJ) exerts anxiolytic-like and antidepressant-like effects in healthy male rats. [9][10][11] There are no data regarding the effect of Aronia melanocarpa (or other berry fruits) on the behavioral consequences of estrogen deficit in OVX rats.…”

Section: Introductionmentioning

confidence: 99%

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Behavioral effects of Aronia melanocarpa fruit juice in a rat model of ovariectomy-induced estrogen deficit

Georgieva¹,

Todorova²,

Eftimov³

et al. 2022

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Introduction: The ovariectomized rat is a model used to mimic the changes in female organism during menopause. Aronia melanocarpa fruit juice (AMFJ) is extremely rich in phenolic substances (procyanidins, flavonoids and phenolic acids). Aim: The present study aimed to evaluate the effects of AMFJ on rat behavior in a model of ovariectomy-induced estrogen deficit. Materials and methods: Four groups of female Wistar rats were used, each consisting of 14 animals – sham operated (SO), ovariectomized (OVX), OVX+AMFJ5, and OVX+AMFJ10. After two-week recovery from the operation, three-month oral treatment was performed with distilled water for the SO and OVX groups, and AMFJ at doses of 5 ml/kg and 10 ml/kg for the OVX+AMFJ5 and OVX+AMFJ10 groups, respectively. Then, behavioral tests were conducted. Locomotor activity was assessed using the open field test (OFT). Anxiety was evaluated in the OFT, elevated plus-maze test and social interaction test. Depressive behavior was assessed in the forced swim test. Thermal pain sensitivity was measured in the hot plate test. Results: OVX rats showed increased anxiety, depressive behavior and pain sensitivity in comparison with SO animals. Compared to OVX rats, anxiety, depressive behavior, and pain sensitivity of AMFJ-treated animals were decreased. Locomotor activity of AMFJtreated rats was reduced in comparison with both SO and OVX animals, probably due to the sedative effect of the juice. Conclusions: AMFJ was able to antagonize the negative impact of the estrogen deficit on rat behavior (anxiety, depression, pain sensitivity), probably due to the biological activity of its polyphenolic ingredients.

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Section: Discussionmentioning

confidence: 98%