Effects of aroA deleted E. coli vaccine on intestinal microbiota and mucosal immunity

Beirão, Breno Castello Branco; Ingberman, Max; Mesa, Dany; Salles, G. B. C.; Muñíz, Eduardo; Caron, Luíz Felipe

doi:10.1016/j.cimid.2021.101612

Cited by 4 publications

(6 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following vaccination with E. coli at 1 day of age, richness of cecal pouch microbiota was lower than that of the control group at 3, 14, and 25 days of age. This one-time vaccination with the aroA-deleted E. coli vaccine also enriched genera like Lactobacillus and Escherichia at 3 days of age, Streptococcus and Peptoclostridium at 14 days of age, and Subdoligranulum, Ruminococcus, and Alistipes at 25 days of age [98].…”

Section: Vaccine Administration and Its Influence On Gut Microbiome S...mentioning

confidence: 83%

“…Furthermore, the implications for the enrichment of these genera in a bird's cecal pouch are not yet understood [95]. In response to antibiotic-free production practices, avian pathogenic E. coli vaccination programs are being integrated into commercial poultry management to reduce the prevalence of colibacillosis in flocks [96][97][98][99]. For example, Beirão et al [98] vaccinated Cobb broiler chicks with a commercially available aroA-deleted E. coli vaccine and assessed the cecal microbiota.…”

Section: Vaccine Administration and Its Influence On Gut Microbiome S...mentioning

confidence: 99%

“…In response to antibiotic-free production practices, avian pathogenic E. coli vaccination programs are being integrated into commercial poultry management to reduce the prevalence of colibacillosis in flocks [96][97][98][99]. For example, Beirão et al [98] vaccinated Cobb broiler chicks with a commercially available aroA-deleted E. coli vaccine and assessed the cecal microbiota. Following vaccination with E. coli at 1 day of age, richness of cecal pouch microbiota was lower than that of the control group at 3, 14, and 25 days of age.…”

Section: Vaccine Administration and Its Influence On Gut Microbiome S...mentioning

confidence: 99%

See 2 more Smart Citations

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

Beck,

Zhao,

Erf

2024

Applied Sciences

View full text Add to dashboard Cite

At the turn of the 21st century, the importance of maintaining a balanced microbiome was brought to the forefront of the microbiology, immunology, and physiology research fields. Exploring the complex interactions between vaccine administration, mucosal microbiome, oral tolerance, and enteric inflammation in health and disease is challenging since environmental factors (such as diet and sanitation) have major influences on gut microbiota composition. High enteric pathogen load has been shown to contribute to dampened cell-mediated and humoral immune responses to vaccines in human case studies, either through elevated enteric inflammation or increased tolerance to environmental microbes. Although antibiotic and probiotic interventions have been evaluated in human health as well as research animal models, effective measures to mediate vaccine hyporesponsiveness are still ill-defined. Research in this field is becoming increasingly important for managing flock health in commercial poultry production, especially as antibiotic-free production is more prevalent and vaccination programs remain extensive during the first weeks of a bird’s life. By understanding the cellular interactions between commensal microbiota, vaccine antigens, and the host immune system (particularly in avian models), advancements in bacterial and viral vaccine immunogenicity could lead to improved flock health in meat-type and egg-type chickens in the future.

show abstract

Section: Vaccine Administration and Its Influence On Gut Microbiome S...mentioning

confidence: 83%

Section: Vaccine Administration and Its Influence On Gut Microbiome S...mentioning

confidence: 99%

Section: Vaccine Administration and Its Influence On Gut Microbiome S...mentioning

confidence: 99%

See 1 more Smart Citation

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

Beck,

Zhao,

Erf

2024

Applied Sciences

View full text Add to dashboard Cite

show abstract

“…To our knowledge, modulation of microbial metabolites in chickens derived from vaccinated hens has not been described to date. However, several studies have reported effects of vaccination on the cecal microbiota [ 37 , 38 , 39 ] of chickens. At this point, investigating IgY, IgM, and IgG levels in broiler chickens would likely have further increased the validity of our results.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a previous study determined no significant effects of a live attenuated IBV (Infectious Bronchitis Virus) vaccine on the Shannon or inverse Simpson indexes of the cecal contents of nine-week-old chickens [ 37 ]. Two other publications even reported decreased OTU (operational taxonomic unit) numbers in cecal samples from laying hens vaccinated with a live attenuated S. enteritidis vaccine [ 40 ] and Cobb broilers vaccinated with a live E. coli vaccine [ 38 ], respectively. Nevertheless, these outcomes derived from active immunization may not be fully comparable to the impact of maternal immunity on the intestinal microbial diversity indices demonstrated in our study.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Specific Pre- and Probiotic Combination and Parent Stock Vaccination on Performance and Bacterial Communities in Broilers Challenged with a Multidrug-Resistant Escherichia coli

et al. 2022

View full text Add to dashboard Cite

Antibiotic resistance poses a risk for human and animal health, leading to a growing demand for effective alternatives. Combining nutritional tools and parent stock vaccination could be an approach to achieve sufficient protection against bacterial infections in poultry. In an Escherichia coli O1/O18 challenge trial, we investigated the protective effects of feeding diets containing Enterococcus faecium DSM 7134 and fructooligosaccharides (FOS) combined with specific parent stock vaccination in 225 ROSS 308 broilers. Data on performance parameters, intestinal microbial composition and metabolites, and antibiotic resistance genes (sul1-3, dhfr1a, SHV-12) were obtained. E. faecium and FOS combined with parent stock vaccination led to the highest body weights, which were significantly higher than those of controls throughout the experiment and decreased the relative abundance of Proteobacteria in the crop digesta compared to that in the positive control. However, cumulative feed conversation remained unaffected by the strategies. Birds receiving the pre-/probiotic combination showed lower cecal pH levels and higher crop L-lactate concentrations than the controls, whereas copy numbers of dhfr1a (trimethoprim resistance) and SHV-12 (extended-spectrum beta-lactamase) genes were only decreased in broilers from vaccinated hens compared to those in the challenged control. In conclusion, prophylactic administration of E. faecium and FOS in combination with parent stock vaccination can have complementary effects by improving broiler weight gain and stimulating intestinal bacterial metabolism, which may be beneficial for maintaining gut health in terms of Escherichia coli infection.

show abstract

Two Bordetella bronchiseptica attenuated vaccine candidates confer protection against lethal challenge with B. Bronchiseptica and Pasteurella multocida toxin in mouse models

Zhang

Lin

Yang

et al. 2022

Vaccine

View full text Add to dashboard Cite

Effects of aroA deleted E. coli vaccine on intestinal microbiota and mucosal immunity

Cited by 4 publications

References 32 publications

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

Effects of a Specific Pre- and Probiotic Combination and Parent Stock Vaccination on Performance and Bacterial Communities in Broilers Challenged with a Multidrug-Resistant Escherichia coli

Two Bordetella bronchiseptica attenuated vaccine candidates confer protection against lethal challenge with B. Bronchiseptica and Pasteurella multocida toxin in mouse models

Contact Info

Product

Resources

About