Effects of Argon Laser Trabeculoplasty in the Early Manifest Glaucoma Trial

Heijl, Anders; Peters, Dorothea; Leske, M. C.; Bengtsson, Bo

doi:10.1016/j.ajo.2011.04.036

Cited by 23 publications

(30 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to this finding, Heijl et al. () showed in the EMGT that each 3 mmHg higher IOP value before ALT was associated with an additional mean IOP reduction of approximately 2 mmHg after ALT. This might be important as every mmHg IOP reduction slows progression by 10 per cent as was shown in the EMGT (Leske et al.…”

Section: Discussionsupporting

confidence: 71%

“…Heijl et al. () reported similar findings using argon laser trabeculoplasty (ALT) in the Early Manifest Glaucoma Trial (EMGT). Therefore, the indication for SLT has to be put cautiously in patients with low pre‐SLT IOPs.…”

Section: Discussionmentioning

confidence: 80%

“…Heijl et al. () also showed that there is no correlation of the stage of the disease with ALT outcome.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Preoperative intraocular pressure as a predictor of selective laser trabeculoplasty efficacy

Pillunat

Spoerl

Elfes

et al. 2016

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 80%

See 1 more Smart Citation

Preoperative intraocular pressure as a predictor of selective laser trabeculoplasty efficacy

Pillunat

Spoerl

Elfes

et al. 2016

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…Laser trabeculoplasty, drainage implants (i.e., seton/tube/shunt) surgery or ciliary body ablation have all been used and provide shorter or longerterm benefit but are all associated with moderate risks [13,14]. Newer techniques that hold potential as surgical options in primary open-angle glaucoma include deep sclerectomy/viscocanalostomy with or without collagen implant and 360-degree suture canaloplasty are being evaluated.…”

Section: Current Standard Of Carementioning

confidence: 99%

Role of Brain-Derived Neurotrophic Factor for the Treatment of Glaucoma and Retinitis Pigmentosa

Spaccapelo¹

2016

MOJT

View full text Add to dashboard Cite

Primary open-angle glaucoma (POAG) is the most common form of glau¬co¬ma, representing up to 90% of cases. POAG is described as a multifactorial optic neuropathy that is chronic and progressive with a characteristic acquired loss of optic nerve fibres. The cause for the elevated is generally IOP accepted to be decreased facility of aqueous outflow through the trabecular meshwork. Retinitis pigmentosa (RP) is a group of relatively rare, inherited disorders characterized by progressive peripheral vision loss and night vision difficulties (nyctalopia) that can lead to central vision loss due to the degeneration of the rod photoreceptor cells in the retina. RP manifests initial symptoms in-dependent of age; thus, RP diagnosis occurs anywhere from early infancy to late adulthood. Brain-derived neurotrophic factor (BDNF) is a 14 kDa protein belonging to the neurotrophin family of growth factors. BDNF has trophic functions in the hippocampus, cortex, and basal forebrain as well as the retina, motor neurons, the kidneys, saliva, and the prostate. The notion that BDNF may have a role in treating the neurodegenerative aspects of POAG is underpinned by convincing preclinical evidence in animal models of glaucoma that BDNF administered intravitreously can, at least in part, rescue retinal ganglion cells (RGCs) under conditions such as those induced by increased intraocular pressure(IOP). Overall, and despite a mechanistically sound rationale, the pharmacokinetic challenges indicate that instilled BDNF topical administration is associated with higher than normal risks, likely explaining the emphasis on alternative approaches (such as synthetic small molecule BDNF analogues or gene therapy approaches) in the last decade. Moreover, the high BDNF doses required to drive efficacy (and low target tissue penetration) also raise concerns over promotion of tumour growth resulting from BDNF taken up from non-retinal tissues. In conclusion, even if preliminary evidences are available, further studies are necessary in order to clarify the role of BDNF for the treatment of glaucoma and retinitis pigmentosa. Keywords:

show abstract

“…6 Although laser and surgical treatment options are available for this purpose, topical medical treatment is the most frequent and the most preferred method. [7][8][9] Patients use one or several eye drops regularly every day. 10 Majority of glaucoma patients instill eye drops by keeping their heads in the hyperextension position.…”

mentioning

confidence: 99%

Neck Pain and Disability: Eye Drop Installation Technique As A Causative Factor

et al. 2014

View full text Add to dashboard Cite

Objectives: This study aims to investigate a possible relationship between long standing eye drop usage and neck pain and to determine the optimal neck position while instilling the eye drop. Patients and methods: Sixty-seven patients who admitted to the ophthalmology outpatient clinic with the diagnosis of glaucoma and using eye drops for at least one year were included in the study as group 1 (n=31). The ages of the patients were between 18 to 80 years. A control group (group 2, n=36) was selected from age-matched individuals who did not use eye drops. The neck disability index form and a study form which included demographic data and the method of eye drop usage of patients were filled. Results: The mean age of the patients were 55.7±11.5 and 53.5±17.1 years for group 1 and group 2, respectively. There was no significant difference in the age and sex between the groups (p=0.526 and p=0.396, respectively). Compared to the controls, the chronic eye drop usage and its application method produced significant difference in neck disability index (p<0.001). Also, there was a positive correlation between neck disability index and number of eye drop usage per a day and period of eye drop usage (p=0.003 and p=0.004, respectively). Conclusion: Neck posture which is not placed in hyperextension position during administration of eye drop may reduce postural neck malpositionrelated neck disability. Patients who are on eye drop for a long time should be informed about postural disorders and instructed to correct the administration of eye drop technique to avoid neck pain.

show abstract

Effects of Argon Laser Trabeculoplasty in the Early Manifest Glaucoma Trial

Cited by 23 publications

References 35 publications

Preoperative intraocular pressure as a predictor of selective laser trabeculoplasty efficacy

Preoperative intraocular pressure as a predictor of selective laser trabeculoplasty efficacy

Role of Brain-Derived Neurotrophic Factor for the Treatment of Glaucoma and Retinitis Pigmentosa

Neck Pain and Disability: Eye Drop Installation Technique As A Causative Factor

Contact Info

Product

Resources

About