Effects of arginine vasotocin on sodium and potassium metabolism in Xenopus laevis after skin gland stimulation and sympathetic blockade

Ireland, M.P.

doi:10.1016/0300-9629(73)90501-x

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Our finding that adrenergic nerve endings are present at the junction between the myoepithelial cell envelope and the secretory compartment supports the view that the discharge of the granular glands is under direct nervous control and provides a morphological basis for the interpretation of previous studies that secretion by dermal glands in X. laevis is stimulated by adrenaline (15)(16)(17).…”

Section: Discussionsupporting

confidence: 88%

Caerulein secretion by dermal glands in xenopus laevis

Dockray¹,

Cr²

1975

The Journal of Cell Biology

128

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Since gastrin and its related peptides are secreted by a minority population of widely dispersed cells in mammalian tissues it has, in the past, been difficult to study the subcellular aspects of their secretion. From published reports (I, 2) it seemed possible that a satisfactory system for such studies might be provided by the skin of certain amphibians such as Xenopus laevis since in these tissues high concentrations of peptides such as caerulein exist, and there is some indication (3) that this, or a similar gastrin-like peptide, may be a dermal gland secretory product. We have therefore explored this possibility by studying the structure, secretory process, and secretory product of the most prominent nonmucous type of gland in the skin of X.laevis. These studies clearly demonstrate that most, if not all, of the caerulein in the skin is contained in secretion granules within the dermal glands and that its release can be specifically evoked by adrenergic stimulation. The release process by a holocrine mechanism expels all of the stored secretion onto the skin surface and thus for 724

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Section: Discussionsupporting

confidence: 88%