Effects of aqueous leaf extracts of Loranthus micranthus Linn. on hematological profile of albino rats infected with Trypanosoma brucei brucei

Egbuji, Jude Victor; Ejere, Vincent Chikwendu; Ugwu, Godwin C.; Okanya, Chinagorom Laureta

doi:10.1007/s00580-019-02973-4

Cited by 2 publications

(4 citation statements)

References 18 publications

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“…The plant was identified by Mr. Alfred O. Ozioko of the Department of Plant Science and Biotechnology, University of Nigeria, Nsukka, where the voucher specimen (LM-KA, 2019-1) was deposited. The leaves were collected and shade dried for two (2) weeks. The dried leaves were reweighed using an analytical balance and were reduced to fine powder using a milling machine (Honda: model 622, China).…”

Section: Methodsmentioning

confidence: 99%

“…The extraction was done using a previously described method. 21 About 500 g of the plant fine powder macerated in 1L of distilled water and allowed to stand for 24 h at 25 0 C, with periodic shaking to increase the extraction capacity. The mixture was filtered using a 60 mm muslin cloth, and then concentrated to dryness in an oven at 45 0 C. About 500 g of the extract was re-dissolved in normal saline and used to prepare the stock solution for oral administration to the animals according to their body weights.…”

Section: Methodsmentioning

confidence: 99%

“…For many decades, trypanosomiasis has affected immensely the social and economic well-being of Africans in sub-Saharan regions and its incidence remains a source of worry in the tropics and the rest of the world. 1,2 The development of livestock industry in Sub-Sahara Africa has been greatly limited by the menace of African trypanosomiasis. 3 Due to their presence in the blood, these parasites produce several changes in the blood constituents.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Aqueous Leaf Extracts of Loranthus micranthus Linn. on Biochemical Profile of Wistar Rats Infected with Trypanosoma brucei brucei

2023

TJNPR

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Thus, the need for the development of affordable, safe and effective drugs for the treatment of trypanosomiasis has resulted in the study of medicinal plants that have an anti-trypanosomal effect. Several herbal medicines have been discovered as good trypanosides. 10,11 But, this use of L. micranthus is yet to be authenticated. African mistletoe (L. micranthus) is an obligate semi-parasite that depends on its host to obtain water and minerals but can carry out photosynthesis. 12 Trees such as Kola acuminata, Kola nitida, magnifera indica, Azadirachta indica, Jatropha curcas and persia sp are the host on which L. micranthus could grow. 13 It is commonly seen in the tropical rainforest region of Africa, Europe and America. 14 African mistletoes constitute several species with the Loranthus being the most common in Nigeria. This specie has been used traditionally by the people in Nigeria as an anti-cancer, anti-hypertensive, anti-diabetic and indeed as an all-purpose herb. 15 The herb has been analyzed and observed to contain many anti-nutrients. 16 It is used as alternative medicine in the treatment of epilepsy, headache, infertility, menopausal syndrome and rheumatism. 17 It is equally used in many parts of West Africa as an anti-microbial and antiplasmodial agent. 18 In recent times, herbal medicines have become indispensable and are forming an integral part of the primary health care system of many nations. The practices of herbal medicines have produced results of proven efficacies compared to orthodox medicine. 19 However, the quest for better, safe and affordable drugs has triggered more research into herbal drugs, which led to the introduction of herbal preparations for therapeutic uses. In recent times, herbal medicines have become indispensable and are forming an integral part of the primary health care system of many nations. Furthermore, the gains from herbal medicine, especially in developing countries, were inadequate due to lack of scientific basis, warranting that the quality and consistency of the alternative medicines be ascertained and maintained for their maximal

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Aqueous Leaf Extracts of Loranthus micranthus Linn. on Biochemical Profile of Wistar Rats Infected with Trypanosoma brucei brucei

2023

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“…A spectrophotometer was used to conduct the measurements in order to produce precise and quantitative data (model T80, UV/visible, double beam, U.K). 15 Haematological assays A computerised haematology analyzer (2800 Haematology Auto-Analyzer) was used to perform a haematological examination on the blood samples. White blood cell (WBC), red blood cell (RBC), haemoglobin concentration (Hg), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and mean corpuscular haemoglobin concentration (MCHC) were among the 14 parameters that were assessed.…”

Section: Biochemical Assaymentioning

confidence: 99%

Evaluation of The Toxic Effects of Ethanolic Leaf Extract of Tapinanthus cordifolius in Mice and Rats

2023

TJNPR

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IntroductionTapinanthus cordifolius is an African mistletoe in the Loranthaceae family and the Tapinanthus genus. 1,2 Mistletoe refers to woody shoot parasites found in a variety of plant groups, including the Loranthaceae and Viscaceae families. 1 The Hausa, Yoruba, and Ibo speakers in Nigeria refer to it as "kaucì", "ewe afomo," and "ohumagana" respectively. 1 It is an obligatory hemi-parasitic evergreen tropical plant that grows on a wide range of trees. 1 In West Africa, mistletoe can be found on a variety of indigenous trees as well as several economically important tree crops, such as shea butter, neem, cocoa, and rubber. Mistletoe is prevalent in South-western Nigeria, especially on tree crops such as cocoa, kola, coffee, bush mango, and others. Mistletoe can also be found on citrus trees such as oranges and guava trees. It grows as a parasitic plant on the branches and trunks of trees, sending out haustoria that pierce the tree to absorb nutrients. Mistletoe, like other plants, can also grow on its own and make its sustenance through photosynthesis. 3 Mistletoe is commonly utilized in practically every culture to treat various conditions such as hypertension, cancer, and diabetes, or as a diuretic agent. 1,2 In Nigeria, mistletoe is used to treat a variety of human and animal problems, including stomach aches, diarrhoea, dysentery, wounds, and cancer. Ruminants and local fowls enjoy it with no documented digestive problems. 3,4

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Effects of aqueous leaf extracts of Loranthus micranthus Linn. on hematological profile of albino rats infected with Trypanosoma brucei brucei

Cited by 2 publications

References 18 publications

Effects of Aqueous Leaf Extracts of Loranthus micranthus Linn. on Biochemical Profile of Wistar Rats Infected with Trypanosoma brucei brucei

Effects of Aqueous Leaf Extracts of Loranthus micranthus Linn. on Biochemical Profile of Wistar Rats Infected with Trypanosoma brucei brucei

Evaluation of The Toxic Effects of Ethanolic Leaf Extract of Tapinanthus cordifolius in Mice and Rats

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