Effects of aquatic exercise on dimensions of quality of life and blood indicators in patients with beta-thalassemia major

Dehkordi, Ali Hasanpour; Hasani, Toba; Fekri, Kiavash; Deris, Fatemeh; Etemadifar, Shahram

doi:10.4103/ijpvm.ijpvm_290_19

Cited by 6 publications

(7 citation statements)

References 25 publications

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“…In addition to clinical conditions, it appears that alterations in lifestyle, social relationships, and psychological events showed improvement in treatment outcomes ( 93 , 94 ). Furthermore, it was observed that regular exercise programs combined with drug therapy and blood transfusion can improve HRQOL in beta-thalassemia patients ( 95 ).…”

Section: Resultsmentioning

confidence: 99%

Health-related quality of life in hemoglobinopathies: A systematic review from a global perspective

2022

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BackgroundSickle cell disease (SCD) and thalassemia are inherited blood disorders, which can lead to life-threatening events and chronic organ damage. Recent advances in treatments have increased life expectancy, and hemoglobinopathies have become chronic illnesses with social and emotional impairments. Thus, health-related quality of life (HRQOL) assessment has a fundamental role in disease management and treatment, and generic and disease-specific questionnaires are reliable and validated measures to estimate disease burden. The heterogeneous distribution of treatment opportunities worldwide influences physical, social, and emotional disease perception.ObjectivesTo review publications concerning HRQOL for SCD and thalassemia in different areas of the world in order to gather a global perspective of questionnaires used and outcomes evaluated.MethodsA systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Medline databases were searched on 29 September 2021. Inclusion criteria were as follows: (1) studies of HRQOL assessment in SCD and thalassemia patients by using the PROMIS, the SF-36, the SCSES, the PedsQL-SCD, the PedsQOL generic core scale, the ASCQ-Me, and the TranQoL; and (2) every article type, including non-English studies. We excluded studies that were not limited to SCD or thalassemia and studies that were not specific to hemoglobinopathies, and not consistent with the topic of HRQOL assessment. We did not include the gray literature. A total of 102 out of 124 articles from PubMed, Cochrane Library, and Google Scholar were eligible for inclusion (66 SCD articles and 36 thalassemia articles). The quality of studies was assessed through Critical Appraisal tools for use in JBI Systematic Reviews. Data extraction was conducted using a standardized data collection form (authors, year and country of publication, study design, age and number of patients, HRQOL questionnaires, questionnaire language, and clinical outcomes).ResultsThe evaluation of HRQOL was conducted on all continents, but differences in the worldwide frequency of HRQOL assessment were observed. HRQOL of SCD patients was less investigated in Europe. HRQOL of thalassemia patients was less investigated in South-East Asia and Africa. Generic HRQOL questionnaires (PROMIS, SF-36, and PedsQL) were frequently adopted, while disease-specific ones (ASCQ-Me, SCSES for SCD, and TranQoL for thalassemia) were less used. Translation into local languages has been often performed.ConclusionHealth-related quality of life is a complex outcome that has been increasingly incorporated in clinical research and clinical practice worldwide, although with regional differences. Disease-specific outcomes (pain for SCD and transfusion burden for thalassemia) and healthcare system characteristics, particularly in low-income countries, have an impact on HRQOL and should be considered in healthcare plans.

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Section: Resultsmentioning

confidence: 99%

Health-related quality of life in hemoglobinopathies: A systematic review from a global perspective

2022

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“…Wagner et al [ 29 ], measuring CPET and vigorous-intensity physical activity using a triaxial accelerometer in 502 subjects from the general population, found a strong positive association with higher V’O 2 peak and other performance-related CPET parameters, supporting the implementation of higher-intensity aerobic exercise in health promotion. Exercise, especially aerobic activities, demonstrated to improve the QoL in TM patients [ 30 ]. Unfortunately, few TM patients perform a regular physical activity due to misconception that anaemia is a limiting factor, and virtually no one is recruited in a program of physical rehabilitation that may help to reduce exercise intolerance.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, few TM patients perform a regular physical activity due to misconception that anaemia is a limiting factor, and virtually no one is recruited in a program of physical rehabilitation that may help to reduce exercise intolerance. No proper exercise program has been designed yet for these patients, but a planned walking program is recommended to improve their QoL, and a regular aquatic exercise program helps patients to maintain or increase the level of performance [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiopulmonary testing in adult patients with β-thalassemia major in comparison to healthy subjects

et al. 2022

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β-Thalassemia patients often have a reduced capacity of exercise and abnormal respiratory function parameters, but the reasons are unclear. In order to identify the causes of the exercise limitation, we performed a cardiopulmonary exercise testing (CPET) in a group of 54 adult β-thalassemia major (TM) patients without pulmonary arterial hypertension and in a group of healthy control subjects. All subjects underwent cardiac echocardiography and carried out pulmonary function tests. TM patients also filled an IPAQ questionnaire on usual physical activity (PA).Overall, TM patients have a diminished exercise performance in comparison to control subjects. In fact, peak oxygen uptake (V’O2 peak), expressing maximum exercise capacity, was decreased in 81.5% of the patients; similarly, anaerobic threshold (V’O2@AT) and O2 pulse also resulted lowered. In multivariable regression models adjusted for gender, age, BMI, and mean haemoglobin, V’O2 peak and O2 pulse were positively associated with cardiac iron overload (T2*). No ventilatory limitation to exercise was observed. The most important causes of exercise limitation in these patients were muscular deconditioning and reduced cardiac inotropism due to iron deposition. Only 15/54 (27.8%) TM patients used to perform vigorous physical activity. These results suggest that a program of regular physical activity may be useful to increase the tolerance to effort and therefore to improve the quality of life in these patients.

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“…Investigators observed an improvement in self-reported quality of life measures in the experimental cohort, which was attributed to exercise. More recently, 40 adult TDT patients were assigned to water exercise three times per week for 8 weeks [ 37 ]. Similar positive effects on quality of life were observed following this exercise regimen, reinforcing the potential beneficial effect of exercise in Thal.…”

Section: Discussionmentioning

confidence: 99%

Relationships among Physical Activity, Pain, and Bone Health in Youth and Adults with Thalassemia: An Observational Study

Fung¹,

Goldberg²,

Bambot³

et al. 2022

Thalassemia Reports

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Patients with thalassemia (Thal) engage in less physical activity than non-Thal populations, which may contribute to pain and osteoporosis. The purpose of this study was to assess relationships between physical activity, pain, and low bone mass in a contemporary sample of patients with Thal. Seventy-one patients with Thal (50 adults ≥18 years, 61% male, 82% transfusion-dependent) completed the Brief Pain Inventory Short Form and validated physical activity questionnaires for youth and adults. Nearly half of the patients reported daily somatic pain. Using multiple regression, after controlling for age and gender, sedentary behavior was positively associated with pain severity (p = 0.017, r2 = 0.28). Only 37% of adult participants met CDC recommendations for physical activity. Spine BMD Z-score was higher (−2.1 ± 0.7) in those who met activity guidelines compared to those who did not (−2.8 ± 1.2, p = 0.048). A positive relationship was observed between self-reported physical activity (hours/week) and hip BMD Z-score in adults with Thal after controlling for transfusion status and sedentary activity time (p = 0.009, r2 = 0.25). These results suggest that decreased physical activity and increased sedentary behavior contribute to low bone mass, which may be related to pain severity in some patients with Thal. Studies focused on increasing physical activity may contribute to improved bone health and reduced pain in patients with Thal.

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Effects of aquatic exercise on dimensions of quality of life and blood indicators in patients with beta-thalassemia major

Cited by 6 publications

References 25 publications

Health-related quality of life in hemoglobinopathies: A systematic review from a global perspective

Health-related quality of life in hemoglobinopathies: A systematic review from a global perspective

Cardiopulmonary testing in adult patients with β-thalassemia major in comparison to healthy subjects

Relationships among Physical Activity, Pain, and Bone Health in Youth and Adults with Thalassemia: An Observational Study

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