Effects of apomorphine on escape performance and activity in developing rat pups treated with 6-hydroxydopamine (6-OHDA)

Lipton, Susan; McGough, Joy P.; Shaywitz, Bennett A.

doi:10.1016/0091-3057(80)90241-5

Cited by 16 publications

(3 citation statements)

References 27 publications

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“…Administration of amphetamine before conditioning reversed the effect of 6-OHDA. The results support the findings that young rats with selective depletion of brain DA are impaired in appetitive as well as aversive learning paradigms (Lipton et al, 1980;Shaywitz et al, 1979;Shaywitz et al, 1978;Shaywitz et al, 1981; Weldon et al, 1982).…”

Section: Discussionsupporting

confidence: 87%

“…In addition to alterations in activity levels, rats tested for avoidance and escape learning are impaired in their performance at age 20 days and beyond (Lipton, McGough, & Shaywitz, 1980;Shaywitz, Goldenring, & Wool, 1979;Shaywitz, Klopper, & Gordon, 1978;Shaywitz, Lipton, Teicher, Cohen, Anderson, Batter, & Young, 1981;Smith, Cooper, & Breese, 1973).…”

Section: Wool Et Almentioning

confidence: 96%

“…Treatment of neonatal rats with the combination of desmethylimipramine (DMI) and 6-hydroxydopamine (6-OHDA) produces a depletion of brain dopamine (DA) and a series of behavioral effects that includes hyperactivity from postnatal day 15 through 30 (Concannon, Braughler, & Schechter, 1983;Erinoff, MacPhail, Heller, & Seiden, 1979;Miller, Heffner, Kotake, & Seiden, 1981;Pappas, Gallivan, Dugas, Saari, & Ings, 1980;Shaywitz, Yager, & Klopper, 1976; Thieme, Dijkstra, & Stoof, 1980) and a decrease in habituation in a novel environment (Shaywitz, Gordon, Klopper, & Zelterman, 1977;Stoof, Dijkstra, & Hillegers, 1978). In addition to alterations in activity levels, rats tested for avoidance and escape learning are impaired in their performance at age 20 days and beyond (Lipton, McGough, & Shaywitz, 1980;Shaywitz, Goldenring, & Wool, 1979; Shaywitz, Klopper, & Gordon, 1978;Shaywitz, Lipton, Teicher, Cohen, Anderson, Batter, & Young, 1981;Smith, Cooper, & Breese, 1973).…”

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confidence: 99%

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Amphetamine reverses learning deficits in 6‐hydroxydopamine‐treated rat pups

Wool

Weldon

Shaywitz

et al. 1987

Developmental Psychobiology

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At 5 days of age, rat pups were treated with a combination of desmethylimipramine (DMI) and 6-hydroxydopamine (6-OHDA) to selectively deplete brain dopamine (DA) or with vehicle (saline) control solutions. Two days later, all animals received conditioning to a novel odor by pairing the odor with intraoral milk. When the odor was anise, treated pups spent less time near the conditioned stimulus than did controls, but there were no 6-OHDA effects when the stimulus was a lemon odor (Experiment I). The difference in performance between the treated and control animals was not attributable to alterations in activating effects of the reinforcer (Experiment I), changes in olfactory sensitivity or olfactory preference (Experiment II), or sensitization to the stimulus (Experiment III). In Experiment IV, animals received d-amphetamine sulfate (0.5 mg/kg) prior to conditioning, testing, or both conditioning and testing. Amphetamine treatment before conditioning produced an improvement in performance in animals previously treated with 6-OHDA/DMI, but it impaired performance in controls, regardless of the time of injection. The results indicate a role of brain DA in learning in young rats.

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Section: Discussionsupporting

confidence: 87%

Section: Wool Et Almentioning

confidence: 96%

mentioning

confidence: 99%

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Amphetamine reverses learning deficits in 6‐hydroxydopamine‐treated rat pups

Wool

Weldon

Shaywitz

et al. 1987

Developmental Psychobiology

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Radial arm maze performance in rats following neonatal dopamine depletion

Pearson

Raskin

Shywitz

et al. 1984

Developmental Psychobiology

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Neonatal dopamine (DA) depletion produces learning impairments both during development and throughout adulthood in the rat. The present experiment further investigated the memory capabilities of the dopamine-depleted rat by assessing performance in the radial arm maze. Results showed that, following neonatal injection of 6-hydroxydopamine and desmethylimipramine, lesioned rats per-performed more accurately than controls. In this paradigm, DA-depleted rats tended to enter each arm to obtain a food pellet and not enter unbaited, incorrect arms. The difference in performance of control and treated rats could not be accounted for by differences in locomotor activity, body weights, or motivational factors. A computer analysis of the data revealed that DA-depleted animals adopted a strategy of choosing adjacent arms consecutively, which probably accounted for their superior performance. Results are discussed in terms using algorithms versus extra-maze cues to complete the maze following early brain injury.

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