Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata

Çakırca, Gökhan; Manav, Vildan; Çelik, Hakim; Saraçoğlu, Gülben; Yetkin, Esra Nur

doi:10.5114/ada.2019.83879

Cited by 13 publications

(14 citation statements)

References 30 publications

(44 reference statements)

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“…TAS and TOS levels in serum were measured spectrophotomerically according to Erel’s method [ 15 , 16 ]. Additionally, the OSI value of each participant was calculated by proportioning TOS to TAS [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…There are many antioxidant and oxidant molecules that reflect the oxidative stress state in the organism, but measuring their levels separately is both difficult and costly. Therefore, practically total oxidant status (TOS) and total antioxidant status (TAS) are measured [ 15 , 16 ] and the oxidative stress index (OSI), which reflects the degree of oxidative stress, is calculated by proportioning TOS to TAS [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection

Çakırca

Üstünel

et al. 2021

Ir J Med Sci

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Background Accumulating evidence suggests that oxidative stress is closely related to the pathogenesis and severity of COVID-19 infection. Here, we attempted to compare thiol, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) levels between COVID-19 patients who need and do not need intensive care unit (ICU) support, and determine whether these markers could be used as predictors of ICU admission. Methods We recruited 86 patients with COVID-19 infection and classified them into two groups according to the level of care: ICU group ( n = 40) and non-ICU group ( n = 46). Thiol, TAS, TOS, and OSI levels were determined and compared between the two groups. Results The levels of thiol and TAS in serum were markedly lower in ICU patients than in the non-ICU patients. On the contrary, TOS and OSI levels were markedly higher. Inflammatory markers, including white blood cell, neutrophil, C-reactive protein, procalcitonin, and ferritin, were negatively correlated with the thiol and TAS, and positively correlated with the TOS and OSI. We determined that areas under the ROC curve for thiol, TAS, TOS, and OSI were 0.799, 0.778, 0.713, and 0.780, respectively. Conclusions Our results revealed that the increase in oxidative stress and decrease in antioxidant levels in COVID-19-infected patients were associated with worsening of disease. Thiol, TAS, TOS, and OSI parameters can be used to distinguish between ICU patients and those who do not, among which thiol was the best predictor of ICU requirement.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection

Çakırca

Üstünel

et al. 2021

Ir J Med Sci

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“…A queda de cabelo, principalmente no couro cabeludo, afeta negativamente a aparência estética e a autoestima dos indivíduos. Portanto, os pacientes que sofrem de alopecia areata (AA), uma doença cutânea autoimune, podem estar sujeitos a várias doenças psiquiátricas e a maiores riscos de desenvolver transtorno depressivo maior (TDM) (Cakirca, G., et al, 2020).…”

Section: Discussionunclassified

Fatores de risco associados ao transtorno depressivo maior em uma comunidade universitária

Ferreira

Chavez

Almeida

et al. 2021

RSD

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Objetivo: Foi realizada uma análise descritiva do perfil sociodemográfico dos pacientes diagnosticados com transtorno depressivo maior; além de estabelecer uma correlação sobre fatores pessoais, parâmetros de sensibilidade somática, características fisiológicas e uso de tratamento farmacológico do grupo com TDM e indivíduos saudáveis. Métodos: Foi analisado o banco de dados no período de março a maio de 2019, referente as fichas de avaliação aplicadas aos funcionários e discentes da Universidade Federal do Pará, posteriormente foi feita a avaliação estatística por meio do programa Microsoft Office Excel® 2013 e do Bioestat – versão 5.3. Resultados: No perfil sociodemográfico dos 50 participantes avaliados, 29 (58%) pertenciam ao sexo feminino, com uma forte associação entre o sexo (p= 0.0219) com esse transtorno mental. O funcionamento intestinal alterado apresentou um aumento de 100% entre o GTDM e o GC. Dentre as variáveis referentes as sensações somáticas, a presença do prurido foi a variável com importante diferença entre os grupos, sendo o GC 23 (92%) sem alteração de sensibilidade a coceira, em comparação ao GTDM 11 (44%) pacientes relataram a presença do prurido. Houve associação estatisticamente forte entre a queda de cabelo e a qualidade do sono no grupo com transtorno depressivo. Conclusão: Conclui-se que os pacientes com TDM apresentam fatores de risco próprios do indivíduo e sintomas somáticos que influenciam no curso de resolução da doença. Sugere-se a realização de mais estudos para relacionar características sociodemográficas, presença de sintomas somáticos e interação medicamentosa para identificar possíveis fatores associados ao quadro de depressão maior na população universitária.

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“…13,14 After measuring the TOS and TAS levels, as a further good marker of oxidative stress, the oxidative stress index (OSI) was calculated as follows: OSI= [(TOS/TAS) × 100]. 15…”

Section: What's Newmentioning

confidence: 99%

Thiol‐disulphide balance and total oxidant‐antioxidant status in patients with chronic hepatitis C

Çakırca

Ceylan

Koyuncu

et al. 2021

Int. J. Clin. Pract.

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Chronic hepatitis C (CHC) infection is a liver disease caused by the hepatitis C virus (HCV). It is a major public health problem, affecting approximately 71 million people worldwide, and is one of the leading causes of cirrhosis, hepatocellular cancer and liver-related deaths. It is estimated that approximately 400 000 people died in 2015 from complications related to CHC. 1 Although the mechanism of how HCV induces liver damage is not fully understood to date, it has been suggested that oxidative stress plays a pivotal role in the pathogenesis of CHC. [2][3][4] Oxidative stress, caused by the deterioration of homeostasis between reactive oxygen species (ROS) and antioxidants, triggers liver damage by inducing DNA damage, lipid peroxidation and protein oxidation in the organism. The increased oxidative stress in HCV infection induces hepatic stellate cell activation, DNA damage and gene mutation, which progresses towards liver fibrosis/cirrhosis and hepatocellular carcinoma. 5 Thiols containing the sulfhydryl (SH) group are part of the antioxidant defence system as they are metal chelators, free radical scavengers and thiol/disulphide redox buffer components. The thiol groups of sulphur-containing compounds, the main targets of ROS, react with oxidant molecules to form disulphide bonds (S-S). This process

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Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata

Cited by 13 publications

References 30 publications

Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection

Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection

Fatores de risco associados ao transtorno depressivo maior em uma comunidade universitária

Thiol‐disulphide balance and total oxidant‐antioxidant status in patients with chronic hepatitis C

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