Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia—A Systematic Review

Fernández-Araque, Ana; Verde, Zoraida; Torres-Ortega, Clara; Gil, María Sáinz; Velasco-González, Verónica; González-Bernal, Jerónimo J.

doi:10.3390/jcm11092462

Cited by 18 publications

(12 citation statements)

References 56 publications

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“…Chronic pain patients have benefitted from the development of a diet based on carbohydrates with low glycaemic index together with fruits and vegetables, yogurt, red wine, legumes and fish with occasional meat, eggs and cheese [55], while other workers have found evidence to support the use of olive oil, ancient grains, Mediterranean diet, glutamate and aspartame-free diet and a gluten-free diet in reducing symptoms of fibromyalgia [56]. A further systematic review of antioxidants in fibromyalgia suggested that over half of the studies assessed offered good evidence for efficacy of supplementation with vitamins and coenzyme Q10, and less consistent evidence for benefit from extra virgin olive oil and turmeric [57]. Vegan and FODMAP diets have produced some benefit in fibromyalgia [58] but significant differences in opinion persist at present [11,12,59].…”

Section: Discussionmentioning

confidence: 99%

Food Intolerance and Sensitivity are Associated with Chronic Musculoskeletal Pain in A Self-Selected Community Population

Thomson¹,

Beer²,

Ryan³

et al. 2023

Preprint

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Introduction People are presenting with chronic musculoskeletal pain at a younger age, and many fulfil criteria for fibromyalgia. We have recently shown a strong association between fibromyalgia symptoms and autistic traits in a self-selected community population, with the relationship mediated in part by the presence of hypermobility. Many respondents also described food sensitivities and intolerances. This study explores relationships between food issues and fibromyalgia symptoms in this population Methods The study used a nonexperimental, correlational design with data collected from a volunteer sample of 442 adults (aged 18-60) who completed online self-report questionnaires assessing each of fibromyalgia symptoms (ACR criteria), autistic traits (RAADS score) and hypermobility (Beighton’s test). Subjects were also asked to record any food sensitivities, allergies, or intolerances, along with their consequences. Correlation analyses and linear regressions were used to test the relationships between these features and each of fibromyalgia, autistic traits and hypermobility. Data was analysed using parametric and non-parametric techniques to assess the strength and significance of relationships, causes of variance and the potential mediating effect of food-related symptoms in the correlation between fibromyalgia features and autistic traits Results Our self-selected community population had a mean age of 24 years and was 77% female. The prevalence of fibromyalgia, autistic traits and hypermobility was 40%, 65% and 44% respectively. Half of all subjects reported food sensitivity and 31% reported food intolerance. The incidence of food-related symptoms was higher among subjects who met criteria for fibromyalgia than those who reported autistic traits or hypermobility. Food sensitivity and food intolerance were both more significantly associated with fibromyalgia (r=0.24, p>0.001 and r=0.38, p>0.001) than with autistic traits (r=0.15, p>0.01 and r=0.17, p>0.01). Discussion This is the first community study to provide evidence for a direct association between features of fibromyalgia and reported food intolerance and sensitivity. Although self-selected, the findings in our predominantly young population suggest that gluten and lactose consumption may be associated with higher levels of musculoskeletal pain. Avoidance of these foodstuffs was commonly reported to reduce symptoms. Dietary adjustment may merit further investigation as a therapeutic modality for some patients with fibromyalgia.

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Section: Discussionmentioning

confidence: 99%

Food Intolerance and Sensitivity are Associated with Chronic Musculoskeletal Pain in A Self-Selected Community Population

Thomson¹,

Beer²,

Ryan³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…It is hoped that future research and targeted therapy will be aimed at microvascular dysfunction and its role in the etiology and maintenance of symptoms in these and potential other chronic pain syndromes. These studies would add to the above-mentioned studies demonstrating the effectiveness of antioxidants or free radical scavengers as analgesics for CRPS ( 18 , 19 ) and fibromyalgia ( 40 ), and why combinations of topical agents aimed at improving both arterial and capillary blood flow ( 59 ), or salts and co-crystals comprised of vasodilators and antioxidants are effective analgesics in animal models of CRPS and neuropathic pain ( 60 ).…”

Section: Discussionmentioning

confidence: 99%

“…FM patients also have higher levels of oxygen free radicals in blood mononuclear cells ( 38 ), and neutrophils from FM patients produce greater levels of the oxygen free radical hydrogen peroxide ( 39 ). This may explain why antioxidants have been useful as analgesics for fibromyalgia in some studies ( 40 ).…”

Section: Introductionmentioning

confidence: 99%

Contribution of microvascular dysfunction to chronic pain

Coderre

2023

Front. Pain Res.

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There is growing evidence that microvascular dysfunction is a pathology accompanying various injuries and conditions that produce chronic pain and may represent a significant contributing factor. Dysfunction that occurs within each component of the microvasculature, including arterioles, capillaries and venules impacts the health of surrounding tissue and produces pathology that can both initiate pain and influence pain sensitivity. This mini review will discuss evidence for a critical role of microvascular dysfunction or injury in pathologies that contribute to chronic pain conditions such as complex regional pain syndrome (CRPS) and fibromyalgia.

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“…Additionally, one can also assume that antioxidants can be used as a therapeutic method for soreness discomfort. Currently, numerous types of antioxidants have been tried in treating post-exercise soreness as well as FM discomfort 35 46 47. Among these, vitamins C, E and co-enzyme Q10 might be the most investigated agents.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia

et al. 2023

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ObjectivesMuscle soreness occurs after exercise and also in musculoskeletal diseases, such as fibromyalgia (FM). However, the nosography and pathoetiology of morbid soreness in FM remain unknown. This study aimed to investigate the morbid soreness of FM, evaluate its therapeutic responses and probe its pathophysiology with metabolomics profiling.MethodsPatients with newly diagnosed FM were prospectively recruited and completed self-report questionnaires pertaining to musculoskeletal symptoms. The phenotypes and metabotypes were assessed with variance, classification and correlation analyses.ResultsFifty-one patients and 41 healthy controls were included. Soreness symptoms were prevalent in FM individuals (92.2%). In terms of manifestations and metabolomic features, phenotypes diverged between patients with mixed pain and soreness symptoms (FM-PS) and those with pain dominant symptoms. Conventional treatment for FM did not ameliorate soreness severity despite its efficacy on pain. Moreover, despite the salient therapeutic efficacy on pain relief in FM-PS cases, conventional treatment did not improve their general disease severity. Metabolomics analyses suggested oxidative metabolism dysregulation in FM, and high malondialdehyde level indicated excessive oxidative stress in FM individuals as compared with controls (p=0.009). Contrary to exercise-induced soreness, lactate levels were significantly lower in FM individuals than controls, especially in FM-PS. Moreover, FM-PS cases exclusively featured increased malondialdehyde level (p=0.008) and a correlative trend between malondialdehyde expression and soreness intensity (r=0.337, p=0.086).ConclusionsMorbid soreness symptoms were prevalent in FM, with the presentation and therapeutic responses different from FM pain conditions. Oxidative stress rather than lactate accumulation involved phenotype modulation of the morbid soreness in FM.Trial registration numberNCT04832100.

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Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia—A Systematic Review

Cited by 18 publications

References 56 publications

Food Intolerance and Sensitivity are Associated with Chronic Musculoskeletal Pain in A Self-Selected Community Population

Food Intolerance and Sensitivity are Associated with Chronic Musculoskeletal Pain in A Self-Selected Community Population

Contribution of microvascular dysfunction to chronic pain

Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia

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