Effects of antioxidant vitamins on molecular regulators involved in lung hypoplasia induced by nitrofen

Prenatal treatment with retinoic acid promotes pulmonary alveologenesis in the nitrofen model of congenital diaphragmatic hernia

“…Because volume density of bronchi and vessels did not change, this increased cell number is most likely secondary to the enlarged airspace septi and walls. Other authors have recently found an increased total DNA after vitamin A treatment in the nitrofen model of CDH [32]. As a consequence of the secondary septation, airspaces were smaller and more numerous after the addition of retinoic acid as reflected in airspace volume and total number of airspace measurements, respectively.…”

“…Baptista et al [31] failed to demonstrate any changes in total lung-to-body weight ratio at term when vitamin A was given to nitrofen-treated pregnant rats on gestational day 18. Gonzalez-Reyes et al [32] did not find any changes in lung weight-to-body weight ratio either, but they demonstrated an increase in total DNA and a normalization in thyroid transcription factor 1, hepatocyte nuclear Retinoic acid is the active metabolite of the retinoid pathway. It has been demonstrated that the lipid-laden interstitial fibroblasts synthesize and secrete retinoic acid [33], which induces proliferation of type II cells and enhances tropoelastin gene expression in vitro [12,34].…”

Modulation of Oxidative Stress by Abhrak Bhasma in Drosophila Melanogaster

“…These antioxidant supplements may be natural or synthetic in origin. Vitamins that are naturally occurring compounds play a key role in boosting antioxidant capacity, either directly by participating in free radical scavenging or indirectly by promoting the action of other regulators in antioxidant machinery [5,6,12]. Vitamins, in general, have been used for increasing the lifespan in insects [13].…”

Abnormal platelet-derived growth factor signaling accounting for lung hypoplasia in experimental congenital diaphragmatic hernia

“…In the nitrofen model for CDH, it has been observed that nitrofen increases ROS and alters the cellular redox state [10]. Several authors have reported that antioxidants can stimulate growth of the nitrofen-induced hypoplastic lung, indicating that altered redox state may cause pulmonary hypoplasia in the nitrofen CDH model [11][12][13][14][15][16]. We designed this study to investigate the hypothesis that the pulmonary PDGFA and PDGFRα gene expression is altered in the nitrofen CDH model.…”