Effects of antimigraine drugs on retinal spreading depression

Wiedemann, Meike; Lima, Vera Maura Fernandes de; Hanke, Wolfgang

doi:10.1007/bf00169175

Cited by 42 publications

(32 citation statements)

References 12 publications

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“…Furthermore, information could be obtained on how far the system is away from a regime where no wave propagation is possible. Recent investigations on the influence of migraine-sensitive drugs on the velocity of wave fronts (Wiedemann et al 1996) should be extended to explore their effect on two-dimensional, complex spiral wave dynamics.…”

Section: Resultsmentioning

confidence: 99%

Self-induced splitting of spiral-shaped spreading depression waves in chicken retina

Dahlem

Müller

1997

Exp Brain Res

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Spreading depression (SD) of electroencephalographic activity is a dynamic wave phenomenon in the central nervous system (CNS). The retina, especially the isolated chicken retina, is an excellent constituent of the CNS in which to observe the dynamic behavior of the SD wave fronts, because it changes its optical properties during a SD attack. The waves become visible as milky fronts on a black background. It is still controversial what the basic mechanistic steps of SD are, but certainly SD belongs to the self-organization phenomena occurring in neuronal tissue. In this work, spiral-shaped wave fronts are analyzed using digital video imaging techniques. We report how the inner end of the wave front, the spiral tip, breaks away repeatedly. This separation process is associated with a Z-shaped trajectory (extension approximately 1.2 mm) that is described by the tip over one spiral revolution (period 2.45+/-0.1 min). The Z-shaped trajectory does not remain fixed, but performs a complex motion across the retina with each period. This is the first time, to our knowledge, that established imaging methods have been applied to the study of the two-dimensional features of SD wave propagation and to obtaining quantitative data of their dynamics. Since these methods do not interfere with the tissue, it is possible to observe the intrinsic properties of the phenomenon without any external influence.

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Section: Resultsmentioning

confidence: 99%

Self-induced splitting of spiral-shaped spreading depression waves in chicken retina

Dahlem

Müller

1997

Exp Brain Res

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“…Data suggest that 3-4 weeks' treatment may be necessary to achieve therapeutic efficacy, with potential for increased efficacy with longer treatment (21). Indeed, chronic administration of the drug is essential for the suppression of CSD (23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Migraines with and without aura and their response to preventive therapy with topiramate

et al. 2009

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Data from the Prolonged Migraine Prevention (PROMPT) with Topiramate trial were evaluated post hoc to determine whether topiramate could prevent migraine auras, and whether its efficacy in preventing migraine headaches was similar in patients with (MA; n = 269) and without (MoA; n = 542) aura. Migraines and auras were recorded during prospective baseline, 6-month open-label (OL) topiramate and 6-month double-blind (DB), placebo-controlled phases. In the last 28 OL days, migraines without aura and migraine auras decreased by 43.1% and 54.1%, respectively, in MA patients. MoA patients experienced a 44.3% reduction in migraines. In the DB phase, increases in migraines with placebo vs. topiramate were similar to the full study, but were generally not statistically significant, probably due to lack of power in the subgroup analysis. Similarly, there were no statistically significant changes in number of auras between groups. Thus, topiramate appears to reduce migraine auras in parallel with headache reductions, which are similar in patients with and without aura.

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“…Propanolol is a very effective modulator of tissue excitability reaching the maximum possible effect (50 % slowdown of spread velocity) at 400 m concentration in the bath solution [18]. Atenolol development was justified on the grounds of better affinity for the heart receptors.…”

Section: Amlodipine Eu Standard (μ M)mentioning

confidence: 99%

Intelligent Systems and the Systematization of Pharmacological Knowledge: Application of the In Vitro Retina Model

Lima¹,

Castro²,

Hanke³

2012

TOPHARMJ

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Abstract:In this century, the IT technology will spread intelligent systems based on cameras, sensors and computers across all fields of the human endeavor. The systematization of knowledge will reach new levels of organization and applications. Scientific knowledge will not be an exception. In this paper we present the results of validation tests made with the in vitro retina model in order to propose the systematization of pharmacological knowledge in experimental platforms supplied with data banks. Data banks can be made either for the speeding up of pre-clinical research or for the control of quality of pure substances or pharmaceutical preparations. These applications and other implementations of using the retinal spreading model in pharmacological research will be useful for the users, manufacturers and authorities of regulation of public health.

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Effects of antimigraine drugs on retinal spreading depression

Cited by 42 publications

References 12 publications

Self-induced splitting of spiral-shaped spreading depression waves in chicken retina

Self-induced splitting of spiral-shaped spreading depression waves in chicken retina

Migraines with and without aura and their response to preventive therapy with topiramate

Intelligent Systems and the Systematization of Pharmacological Knowledge: Application of the In Vitro Retina Model

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