2005
DOI: 10.1590/s0074-02762005000400019 View full text |Buy / Rent full text
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Abstract: Antimalarial drugs including the antifolate, pyrimethamine-sulfadoxine (PS), df = 1, P = 0.02). Gametocyte sex ratio changes were similar following treatment with both drugs. PS and Co-T treatment of acute malaria infections in children from this endemic area is associated with significant increases in prevalence and intensities of gametocytaemia but these effects are more marked in those treated with PS than Co-T.

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“…Thus, when normal doses of these drugs are used, the free concentration of TMP is at least five times higher than that of PM, which would compensate for the relatively low activity of TMP, explaining, at least partly, the comparative efficacies of TMP-SMZ and PM-SD. Thus, in areas of high PM-SD efficacy (low rates of dhfr mutants), PM-SD and TMP-SMZ could have comparative efficacies, as supported by in vivo investigations (14,44,50). However, based on our in vitro data, TMP-SMZ, like PM-SD, will be of marginal efficacy in the context of a high rate of dhfr triple mutant parasites.…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Thus, when normal doses of these drugs are used, the free concentration of TMP is at least five times higher than that of PM, which would compensate for the relatively low activity of TMP, explaining, at least partly, the comparative efficacies of TMP-SMZ and PM-SD. Thus, in areas of high PM-SD efficacy (low rates of dhfr mutants), PM-SD and TMP-SMZ could have comparative efficacies, as supported by in vivo investigations (14,44,50). However, based on our in vitro data, TMP-SMZ, like PM-SD, will be of marginal efficacy in the context of a high rate of dhfr triple mutant parasites.…”
Section: Discussionmentioning
“…The data are summarized in Table 2. The median IC 50 for PM was 370 nM in the double mutant group, and this value increased almost twofold in the triple mutant group. Likewise, IC 50 s for TMP increased from 9,308.6 nM in the double mutant group to 33,655 nM in the triple mutant group, a 3.6-fold increase; however, these differences were not significant.…”
Section: Resultsmentioning
“…La mefloquina tampoco elimina los gametocitos maduros de P. falciparum, sino que evita el desarrollo posterior de esas células por su actividad contra sus precursores (46). La sulfadoxina-pirimetamina es un potente esquizonticida sanguíneo y se sospecha que estimula la producción de gametocitos de P. falciparum (47)(48)(49)(50)(51)(52)(53) o eleva la viabilidad de los maduros (36); la sulfadoxina-pirimetamina suprime la capacidad de los gametocitos para infectar los anofelinos (36) y altera las razones de sexo de los gametocitos, lo que influye en la capacidad de causar infección a los mosquitos y la transmisión del paludismo (54); se considera que el efecto neto o global de la sulfadoxinapirimetamina sobre la supresión de la capacidad de infectar es nulo (36).…”
Section: Antipalúdicos Y Gametocitos De P Falciparumunclassified
“…However, children treated with SP were significantly more likely to have gametocyte carriage on day 14 compared with children treated with TS (65.7% versus 35%, respectively, P = 0.018), suggesting a more marked effect of gametocytemia with SP than TS. 33 The increase in the risk of gametocytemia in children receiving antifolates could be explained by decreased gametocydal activity, drug-induced release of sequestered gametocytes, or development of antifolate drug resistance. In a study of South African patients treated with SP for uncomplicated malaria, increases in the duration of gametocyte carriage after treatment were strongly associated with antifolate resistance markers dhfr and dhps.…”
Section: Discussionmentioning