Effects of antiepileptic drug therapy on heart rate variability in children with epilepsy

Hallioglu, Olgu; Okuyaz, Çetin; Mert, Ertan; Makharoblidze, Khatuna

doi:10.1016/j.eplepsyres.2007.12.020

Cited by 64 publications

(45 citation statements)

References 30 publications

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“…The time domain indicators used in this study included mean HR, which is an indicator of sympathovagal balance; standard deviation in the normal RR interval (STDRR) and HRV triangular index, which are indicators of global HRV [28] ; standard deviation of the selected HR series (STDHR), which is a measure of the long-term components of HRV [28] , and square root of the mean squared differences of successive RR intervals (RMSSD), which is an indicator of parasympathetic nervous system activity [29] . The frequency domain indicators used included the high-frequency component (HF) at [30][31][32][33] , while the autonomic contributions to the LF component are still being investigated and no consensus currently exists. The LF component is said to provide information on sympathetic activity but with notable influences from the parasympathetic nervous system, baroreceptor feedback and brainstem rhythms [34] .…”

Section: Hrv Recordingsmentioning

confidence: 99%

Autonomic Correlates at Rest and during Evoked Attention in Children with Attention-Deficit/Hyperactivity Disorder and Effects of Methylphenidate

Negrao

Bipath²,

Westhuizen³

et al. 2010

Neuropsychobiology

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Objective: The aim of this study was to assess autonomic nervous system functioning in children with attention-deficit/hyperactivity disorder (ADHD) and to examine the effects of methylphenidate and focussed attention. Method: Children with ADHD (n = 19) were tested while they were stimulant free and during a period in which they were on stimulants. On both occasions, autonomic nervous system functioning was tested at baseline and during focussed attention. Autonomic nervous system functioning of control subjects was also tested at baseline and during focussed attention. Autonomic nervous system activity was determined by means of heart rate variability (HRV) and skin conductivity analyses. Attention was evoked by means of the BioGraph Infiniti biofeedback apparatus. HRV was determined by time domain, frequency domain and Poincaré analysis of RR interval data. Skin conductivity was determined by the BioGraph Infiniti biofeedback apparatus. Results: The main findings of this study were (a) that stimulant-free children with ADHD showed a sympathetic underarousal and parasympathetic overarousal of the sympathovagal balance relative to control subjects; (b) methylphenidate shifted the autonomic balance of children with ADHD towards normal levels; however, a normal autonomic balance was not reached, and (c) stimulant-free children with ADHD exhibited a shift in the sympathovagal balance towards the sympathetic nervous system from baseline to focussed attention; however, methylphenidate appeared to abolish this shift. Conclusions: Stimulant-free children with ADHD have a parasympathetic dominance of the autonomic balance, relative to control subjects. Methylphenidate attempts to restore the normal autonomic balance in children with ADHD, but inhibits the normal autonomic nervous system response to a cognitive challenge. Clinical Applications: These results indicate that methylphenidate may have a suppressive effect on the normal stress response. Although this may be of benefit to those who interact with children who suffer from ADHD, the implications for the physiological and psychological well-being of the children themselves are debatable. Further research is needed. Limitations of the Study: Only 19 children with ADHD and 18 control subjects were tested. Further studies should include prior testing in order to exclude children with possible co-existing learning disabilities. Cognitive function and emotional responses of children with ADHD were not tested.

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Section: Hrv Recordingsmentioning

confidence: 99%

Autonomic Correlates at Rest and during Evoked Attention in Children with Attention-Deficit/Hyperactivity Disorder and Effects of Methylphenidate

Negrao

Bipath²,

Westhuizen³

et al. 2010

Neuropsychobiology

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“…Kolsal et al [15] found reduced parasympathetic activity with lower LF and HF in 20 children with refractory epilepsy. Hallioglu et al [9] reported significantly decreased values of SDNN interictally in 92 patients, of whom 55% had partial seizures and 41% generalized seizures. Tomson et al [16] found a reduced HRV (SDNN and total power) and decreased low frequency power and lower LF/HF-ratio in patients with complex partial seizures with a temporal lobe focus compared to controls.…”

Section: Discussionmentioning

confidence: 98%

“…Epileptic seizures can induce changes in the balance between sympathetic and parasympathetic influence on the heart including an acute autonomic dysfunction suspected to play a role in sudden unexpected death in epilepsy (SUDEP) [2][3][4][5][6][7][8][9][10][11][12], and it has been suggested that a high sympathetic tone ictally and interictally is the main cause of lower HRV and SUDEP [2,3].…”

Section: Introductionmentioning

confidence: 99%

Heart rate variability in infants with West syndrome

Møller

Høgenhaven

Uldall

et al. 2015

Seizure

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“…For example, interictal autonomic dysfunction (parasympathetic disturbance) could be improved after achieving clinical recovery (21,33). Ansakorpi et al showed that HRV parameters the patients with partial epilepsy came close to those in control group after beginning anticonvulsant drug therapy (20).…”

Section: Discussionmentioning

confidence: 99%

Abnormal Vasomotor System Function in Idiopathic Generalized Epileptic Patients

Maghbooli¹,

Langroudi²,

Ghoreishi³

et al. 2014

tnd

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Objective: Autonomic dysfunction is widely recognized in both partial and generalized epilepsies. The aim of this study was to evaluate the vasomotor response in patients with generalized idiopathic epilepsy using clinical autonomic function tests. Ma te ri als and Met hods: Hundred and twenty-four consecutive subjects including 62 idiopathic generalized epileptic patients diagnosed for more than 3 months receiving monotherapy and 62 matched for sex and age healthy controls were assessed in this case-control study. The evaluation of the vasomotor system was made using a questionnaire and autonomic function tests including cold pressor, Valsalva maneuver, mental arithmetic and hand-grip tests. Re sults: Abnormal score of the Cold pressor test was seen in 59.7%, Valsalva maneuver in 64.5% and 33.9% in mental arithmetic test of epileptic patients. These results were different significantly in comparison to control group. If abnormal hand grip test was defined as an increase less than 11 mmHg in diastolic pressure, there was found no significant difference between two groups of case and control, also a few people in control group was reported normal. When abnormality was defined as an increase in only one or none of the parameters of systolic blood pressure, diastolic blood pressure or heart rate, 43.5% in patient group versus 14.5% in controls had abnormal results with statistically significant difference. Conclusion: Vasomotor dysfunction assessed with cardiovascular tests was present in patients with generalized epilepsy. Further research on central and peripheral limbs in association with the breakdown of the system is required. (Turkish Journal of Neurology 2014; 20:126-131)

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Effects of antiepileptic drug therapy on heart rate variability in children with epilepsy

Cited by 64 publications

References 30 publications

Autonomic Correlates at Rest and during Evoked Attention in Children with Attention-Deficit/Hyperactivity Disorder and Effects of Methylphenidate

Autonomic Correlates at Rest and during Evoked Attention in Children with Attention-Deficit/Hyperactivity Disorder and Effects of Methylphenidate

Heart rate variability in infants with West syndrome

Abnormal Vasomotor System Function in Idiopathic Generalized Epileptic Patients

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