Effects of antidepressants on cognitive functions: A review

Amado-Boccara, I; Gougoulis, Nicolas; Littré, M F Poirier; Galinowski, A.; H, Lôo

doi:10.1016/0149-7634(94)00068-c

Cited by 182 publications

(76 citation statements)

References 52 publications

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“…Bipolar patients, including those who are euthymic, are usually receiving mood stabilizing (e.g., anticonvulsants or lithium), antipsychotic, antidepressant, or benzodiazepine medications. Both antipsychotic and benzodiazepine medications have been reported to be associated with decreased ACC activity (Amado-Boccara et al 1995;Blumberg et al 2000), and this may affect the amplitude of anterior N200 component. Few studies have reported on the effects of medication on ERP in BD.…”

Section: Discussionmentioning

confidence: 98%

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Sokhadze

Tasman

Tamas

et al. 2010

Appl Psychophysiol Biofeedback

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There appears to be a significant disconnect between symptomatic and functional recovery in bipolar disorder (BD). Some evidence points to interepisode cognitive dysfunction. We tested the hypothesis that some of this dysfunction was related to emotional reactivity in euthymic bipolar subjects may effect cognitive processing. A modification of emotional gender categorization oddball task was used. The target was gender (probability 25%) of faces with negative, positive, and neutral emotional expression. The experiment had 720 trials (3 blocks × 240 trials each). Each stimulus was presented for 150 ms, and the EEG/ERP responses were recorded for 1,000 ms. The inter-trial interval was varied in 1,100-1,500 ms range to avoid expectancy effects. Task took about 35 min to complete. There were 9 BD and 9 control subjects matched for age and gender. Reaction time (RT) was globally slower in BD subjects. The centro-parietal amplitudes at N170 and N200, and P200 and P300 were generally smaller in the BD group compared to controls. Latency was shorter to neutral and negative targets in BD. Frontal P200 amplitude was higher to emotional negative facial non-targets in BD subjects. The frontal N200 in response to positive facial emotion was less negative in BD subjects. The frontal P300 of BD subjects was lower to emotionally neutral targets. ERP responses to facial emotion in BD subjects varied significantly from normal controls. These variations are consistent with the common depressive symptomology seen in long term studies of bipolar subjects.

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Section: Discussionmentioning

confidence: 98%

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Sokhadze

Tasman

Tamas

et al. 2010

Appl Psychophysiol Biofeedback

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“…Especially tricyclics with sedating properties significantly impair driving ability after treatment initiation (Ramaekers 2003). The effects on functional outcome are less clear (Amado Boccara et al 1995;Stein and Strickland 1998;Brunnauer and Laux 2010).…”

Section: Introductionmentioning

confidence: 96%

The effects of most commonly prescribed second generation antidepressants on driving ability: a systematic review

Brunnauer

Laux

2012

J Neural Transm

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Driving a car is vital for the functional autonomy of patients to take part in activities of daily living. Both psychopathologic symptoms and psychopharmacologic treatment may impair driving ability. This article provides a systematic review of published studies (1980-2011) on commonly prescribed newer antidepressants and driving performance. A total of 21 studies could be included in the review, indicating that there is a lack of controlled patient studies. Investigations on newer antidepressants were frequently undertaken in healthy subjects focusing on acute or subchronic effects of application, predominately in young male participants, with dosages usually given in an ambulatory setting. No data, according to selection criteria, were found with respect to agomelatine, duloxetine, bupropion and viloxazine. There is evidence that the SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline, paroxetine) and the SNRI venlafaxine have no deleterious effects on driving ability. Acute use of mirtazapine does produce impairments that diminish to some degree when given as a nocturnal dose and cannot be seen after repeated dosing in healthy controls. Patients obviously benefit from treatment with newer antidepressants; however, at least a subgroup does not reach performance level of healthy subjects. More patient studies are needed that elaborate specific relationships between clinical subtypes of the illness and response to different antidepressants, considering course and duration of illness, co-morbidities and not least neuropsychological and neurobiological characteristics.

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“…For these purposes, we developed an emotional version of the task switching paradigm of Whitmer and Banich (2007), the Affective Shift Task (AST), that we applied to a relatively large sample of healthy and dysphoric or sub-clinically depressed undergraduates. An advantage of conducting this study with a dysphoric sample is the exclusion of medication use, which can influence cognitive functioning (for a review see Amado-Boccara, Gougoulis, Poirier, Galinowski, & Loo, 1995).…”

Section: Aims Of the Present Studymentioning

confidence: 99%

The association between depressive symptoms and executive control impairments in response to emotional and non-emotional information

Lissnyder

Koster

Derakshan

et al. 2010

Cognition & Emotion

170

153

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Depression has been linked with impaired executive control and specific impairments in inhibition of negative material. To date, only a few studies have examined the relationship between depressive symptoms and executive functions in response to emotional information.Using a new paradigm, the Affective Shift Task (AST), the present study examined if depressive symptoms in general, and rumination specifically, are related to impairments in inhibition and set shifting in response to emotional and non-emotional material. The main finding was that depressive symptoms in general were not related to inhibition. Set shifting impairments were only observed in moderate to severely depressed individuals. Interestingly, rumination was related to inhibition impairments, specifically when processing negative information, as well as impaired set shifting as reflected in a larger shift cost. These results are discussed in relation to cognitive views on vulnerability for depression.

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Effects of antidepressants on cognitive functions: A review

Cited by 182 publications

References 52 publications

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

The effects of most commonly prescribed second generation antidepressants on driving ability: a systematic review

The association between depressive symptoms and executive control impairments in response to emotional and non-emotional information

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