Effects of antidepressants in adrenergic neurotransmission of human vas deferens

Decreased noradrenergic and serotonergic reactivity of vas deferens of newborn rats from mothers treated with the serotonin reuptake inhibitor fluoxetine during pregnancy and breast-feeding

“…This was shown through three different groups of experiments: release by tyramine, release by nerve stimulation (EFS), and amperometric real-time detection of released noradrenaline. This result agrees with that of Medina et al (2000) that verified that the response to electrical field stimulation, was not changed when fluoxetine was applied in vitro directly in the organ bath. However, the possibility that changes occur on the release of endogenous sympathetic cotransmitters, as for instance ATP (Conceição et al, 2005), although improbable, was not presently studied.…”

“…Furthermore, Maina et al (2004) verified that the chronic use of antidepressants, during more than 2.5 years, provoked weight increases, while fluoxetine appeared as the antidepressant that less induced weight increase (4.5%) in human patients. This is the first time, to our knowledge, that fluoxetineinduced functional changes are described on newborn animals after exclusive chronic treatment of mothers during pregnancy and breast-feeding, although fluoxetine has been studied in adult vas deferens (Busch et al, 1999(Busch et al, , 2000Medina et al, 2000). The question now arises as to whether or not these noradrenergic and serotonergic alterations are related to potential adverse effects possibly involving smooth muscle neurotransmission symptoms, or comprising the so-called neonatal abstinence syndrome induced by SSRI, as identified by FDA (Moses-Kolko et al, 2005;Sanz et al, 2005).…”

Premature ejaculation: old story, new insights

“…Despite some animal studies showing the role of Ca 2þ in the machinery of ejaculation, the clinical efficacy and safety of different Ca 2þ channel blockers in the treatment of PE have not been studied. It is interesting that two of the drugs used for off-label treatment of PE, sertraline and fluoxetine (70), were demonstrated to inhibit human vas deferens motility in vitro through inhibition of Ca 2þ entry (71). A similar effect has been found with paroxetine (72,73).…”

Effect of sertraline on ouabain-induced arrhythmia in isolated guinea-pig atria

“…[31] The interaction between calcium channel and sertraline was observed in several studies. [32,33] They have reported that the use of SSRIs, sertraline is associated with cases of arrhythmia, prolonged QT interval on electrocardiogram that is independent of its treatment effects. [5,15] Fluoxetine and sertraline potently inhibited the L-type Ca 21 and transient outward K 1 currents.…”