Effects of Anticoagulation Intensity on Hemostatic Markers in Patients With Non-Valvular Atrial Fibrillation

Target International Normalized Ratio Values for Preventing Thromboembolic and Hemorrhagic Events in Japanese Patients With Non-Valvular Atrial Fibrillation

“…22 In a previous study, the effects of the INR value on hemostatic marker levels were analyzed in Japanese patients with NVAF. 23 It was found that the reduction in D-dimer levels observed at an INR of between 1.5 and 1.99 was similar to that seen at an INR of 2.00 or higher. 23 Therefore, an INR of between 1.5 and 1.99 is also effective at preventing thrombus formation in the cardiovascular system, which suggests that lower INR values (between 1.5 and 1.99) are as effective as INR values of between 2 and 3 at preventing embolic events in patients with NVAF.…”

Simple and Useful Tests for Discriminating Between Acute Aortic Dissection of the Ascending Aorta and Acute Myocardial Infarction in the Emergency Setting

“…38,39 Therefore, further investigation is necessary to clarify whether the Ddimer assay can differentiate AADa from these diseases, but we believe that by setting an appropriate cutoff value for the assay AADa can be differentiated from AMI in the emergency department before initiation of reperfusion therapy, even if the D-dimer value is not diagnostic for AADa because of its lack of specificity. 24 …”

Accumulation of Risk Factors Increases Risk of Thromboembolic Events in Patients With Nonvalvular Atrial Fibrillation

“…The diagnostic criteria for these thromboembolic events have been reported previously. 7,8 The INR levels at the time of enrollment, within 6 months of the primary end point and at the time of thromboembolic events were analyzed.…”