Effects of Anticholinergic Drugs on Verbal Episodic Memory Function in the Elderly

Fortin, M.; Rouch, Isabelle; Dauphinot, Virginie; Gédéon, Claire; Genthon, Stella; Bonnefoy, Marc; Krolak‐Salmon, Pierre

doi:10.2165/11586580-000000000-00000

Cited by 36 publications

(25 citation statements)

References 25 publications

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“…Another possible interpretation of our results is that paroxetine, the SSRI that was used to treat MDD in our sample, has a weak anti-nicotinic anticholinergic effect (Fortin et al, 2011; Mertens and Pintens, 1988). The hippocampus has a high concentration of nicotinic cholinergic receptors (Martin and Aceto, 1981).…”

Section: Discussionmentioning

confidence: 83%

Depression impairs learning, whereas the selective serotonin reuptake inhibitor, paroxetine, impairs generalization in patients with major depressive disorder

Herzallah

Moustafa

Natsheh

et al. 2013

Journal of Affective Disorders

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To better understand how medication status and task demands affect cognition in Major Depressive Disorder (MDD), we evaluated medication-naïve patients with MDD, medicated patients with MDD receiving the Selective Serotonin Reuptake Inhibitors (SSRI) paroxetine, and healthy controls. All three groups were administered a computer-based cognitive task with two phases, an initial phase in which a sequence is learned through reward-based feedback (which our prior studies suggest is striatal-dependent), followed by a generalization phase that involves a change in the context where learned rules are to be applied (which our prior studies suggest is hippocampal-region dependent). Medication-naïve MDD patients were slow to learn the initial sequence but were normal on subsequent generalization of that learning. In contrast, medicated patients learned the initial sequence normally, but were impaired at the generalization phase. We argue that these data suggest (i) an MDD-related impairment in striatal-dependent sequence learning which can be remediated by SSRIs and (ii) an SSRI-induced impairment in hippocampal-dependent generalization of past learning to novel contexts, not otherwise seen in the medication-naïve MDD group. Thus, SSRIs might have a beneficial effect on striatal function required for sequence learning, but a detrimental effect on the hippocampus and other medial temporal lobe structures critical for generalization.

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Section: Discussionmentioning

confidence: 83%

Depression impairs learning, whereas the selective serotonin reuptake inhibitor, paroxetine, impairs generalization in patients with major depressive disorder

Herzallah

Moustafa

Natsheh

et al. 2013

Journal of Affective Disorders

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“…Moreover, while all patients in our study were receiving pharmacological therapy, there was a high degree of variability in medication, which may impact cognitive function through different mechanisms of action. Some of these medications, such as selective serotonin reuptake inhibitors (SSRIs), may have positive effects on memory and other cognitive aspects (Cassano, Puca, Scapicchio, & Trabucchi, 2002;Levkovitz, Caftori, Avital, & Richter-Levin, 2002) while others, such as benzodiazepines (Giersch, Boucart, Elliott, & Vidailhet, 2010), and anticholinergic (Fortin et al, 2011) and antipsychotic drugs (Torrent et al, 2011) can have a negative impact on memory and cognitive performance. Even so, it is important to keep in mind that prior studies suggest that cognitive alterations in bipolar patients cannot be explained by medication, since its effects seem to be small (Arts, Jabben, Krabbendam, & Van Os, 2010).…”

Section: Encoding Support Improves Contextual Memory Of Bd Patientsmentioning

confidence: 99%

The role of encoding strategies in contextual memory deficits in patients with bipolar disorder

Corrêa

Silveira

Lima

et al. 2014

Neuropsychological Rehabilitation

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Contextual memory is important for the encoding and retrieval of episodic memory, which is often impaired in euthymic patients with bipolar disorder (BD). The objective was to investigate the effect of low and high cognitive support on encoding in an incidental contextual memory task in euthymic patients with BD. Twenty-three patients with a BD type I diagnosis (aged 23-63 years, 17 women and 6 men) and 29 healthy controls completed a recognition memory task for context (location of a recognised object). Participants were assigned to one of two incidental encoding conditions: (1) with a binding cue to encourage the association of the object to its location (judging the degree of appropriateness of an object in relation to its location) or (2) without a binding cue (judging daily use of objects). Patients showed a deficit in incidental contextual memory in the absence of a binding cue at encoding. Under incidental encoding with the binding cue, no differences were observed between the groups for contextual memory. Contextual memory deficits in BD patients were reduced by providing cognitive support at encoding. The role of this strategy should be investigated in larger samples to evaluate its use for cognitive remediation in BD patients.

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“…No association is found between DBI score and mild cognitive impairment or dementia Fortin et al 34 134 elderly people in the community In a retrospective study, a significant association between the number of anticholinergic drugs used and the alterations in the episodic memory is found by using the Free and Cued Selective Reminding Test. The episodic memory is the first cognitive function that is altered by these drugs Bottiggi et al 7 592 subjects The use of anticholinergic drugs causes a decline over time, irrespective of age, in the performance in TMT-A and TMT-B.…”

Section: Authorsmentioning

confidence: 97%

Effect of anticholinergic drugs on cognitive impairment in the elderly

López-Álvarez

Sevilla

Ortiz

et al. 2015

Revista de Psiquiatría y Salud Mental (English Edition)

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Effects of Anticholinergic Drugs on Verbal Episodic Memory Function in the Elderly

Abstract: Clinicians should assess the current use of drugs with anticholinergic properties in the elderly, particularly in patients presenting for memory evaluation. In such cases, use of other therapeutic alternatives should be considered.

Cited by 36 publications

References 25 publications

Depression impairs learning, whereas the selective serotonin reuptake inhibitor, paroxetine, impairs generalization in patients with major depressive disorder

Depression impairs learning, whereas the selective serotonin reuptake inhibitor, paroxetine, impairs generalization in patients with major depressive disorder

The role of encoding strategies in contextual memory deficits in patients with bipolar disorder

Effect of anticholinergic drugs on cognitive impairment in the elderly

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