Effects of anticancer drug docetaxel on the structure and function of the rabbit olfactory mucosa

Kavoi, Boniface M.; Plendl, Johanna; Makanya, Andrew N.; Ochieng, Shem J; Kiama, Stephen G.

doi:10.1016/j.tice.2014.04.005

Cited by 7 publications

(8 citation statements)

References 88 publications

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“…The administration of these drugs for TC may provide a clinical benefit in adjuvant settings. Doxorubicin induces cilium formation in breast fibroblasts ( 34 ), paclitaxel causes cilium elongation in the quail oviduct ( 35 ), and docetaxel decreases cilia numbers in olfactory cells ( 36 ). In addition, carboplatin induces PC disassembly in sensory cells ( 37 ) and has been used to treat TC.…”

Section: Drugs With Effects On Pcmentioning

confidence: 99%

The Role of Primary Cilia in Thyroid Cancer: From Basic Research to Clinical Applications

et al. 2021

Front. Endocrinol.

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Primary cilia (PC) are microtubule-based organelles that are present on nearly all thyroid follicle cells and play an important role in physiological development and in maintaining the dynamic homeostasis of thyroid follicles. PC are generally lost in many thyroid cancers (TCs), and this loss has been linked to the malignant transformation of thyrocytes, which is regulated by PC-mediated signaling reciprocity between the stroma and cancer cells. Restoring PC on TC cells is a possible promising therapeutic strategy, and the therapeutic response and prognosis of TC are associated with the presence or absence of PC. This review mainly discusses the role of PC in the normal thyroid and TC as well as their potential clinical utility.

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Section: Drugs With Effects On Pcmentioning

confidence: 99%

The Role of Primary Cilia in Thyroid Cancer: From Basic Research to Clinical Applications

et al. 2021

Front. Endocrinol.

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“…Pioglitazone has been shown to have beneficial effects in the treatment of Polycystic Kidney Disease (PKD) [ 26 ]. Cilio-modulatory activities have also been attributed to several other compounds from our screen like triamcinolone, budesonide, paroxetine, oxymetazoline and docetaxel [ 23 , 27 – 30 ]. Imexon, a potent enhancer of cilium length as shown in our results, is a known inducer of apoptosis and cell cycle arrest in pancreatic cancer cells [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of drugs that restore primary cilium expression in cancer cells

et al. 2016

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The development of cancer is often accompanied by a loss of the primary cilium, a microtubule-based cellular protrusion that functions as a cellular antenna and that puts a break on cell proliferation. Hence, restoration of the primary cilium in cancer cells may represent a novel promising approach to attenuate tumor growth. Using a high content analysis-based approach we screened a library of clinically evaluated compounds and marketed drugs for their ability to restore primary cilium expression in pancreatic ductal cancer cells. A diverse set of 118 compounds stimulating cilium expression was identified. These included glucocorticoids, fibrates and other nuclear receptor modulators, neurotransmitter regulators, ion channel modulators, tyrosine kinase inhibitors, DNA gyrase/topoisomerase inhibitors, antibacterial compounds, protein inhibitors, microtubule modulators, and COX inhibitors. Certain compounds also dramatically affected the length of the cilium. For a selection of compounds (Clofibrate, Gefitinib, Sirolimus, Imexon and Dexamethasone) their ability to restore ciliogenesis was confirmed in a panel of human cancer cell line models representing different cancer types (pancreas, lung, kidney, breast). Most compounds attenuated cell proliferation, at least in part through induction of the primary cilium, as demonstrated by cilium removal using chloral hydrate. These findings reveal that several commonly used drugs restore ciliogenesis in cancer cells, and warrant further investigation of their antineoplastic properties.

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“…However, the development of hydrocephalus during or immediately after taxane-based chemotherapy, like in our patient, makes the relationship highly suspicious. The microtubule dysfunction induced by taxanes, destined to impair the mitotic spindle of neoplastic cells, is well known to affect microtubules of ciliated epithelia and therefore its function of removing and clearing particles and fluid over the epithelial surface [ 14 , 15 ]. It is possible that an impairment of ependymal cilia could lead in exceptional cases to a disruption of CSF clearance and circulation, predisposing to the development of hydrocephalus in a very small group of patients.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Docetaxel-Induced Hydrocephalus Presenting with Gait Disturbances Mimicking and Coexisting with Taxane-Associated Polyneuropathy: The Relevance of Differential Diagnosis, Clinical Assessment, and Response to Ventriculoperitoneal Shunt

Sponton¹,

Januschek²

2017

Case Rep Oncol

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Docetaxel constitutes a widely used chemotherapeutic agent as a first-line treatment for several neoplastic diseases. One of the most common side effects induced by this drug is polyneuropathy, which among other symptoms can cause gait disbalance. However, in exceptional cases gait disturbances could be related to docetaxel-induced hydrocephalus, a rare event that up to the present has been overseen throughout the medical literature and should be meticulously differentiated from polyneuropathy, since its clinical features, treatment, and prognosis differ drastically. We present the case of a woman with a progressive gait disturbance that started immediately after having been treated with docetaxel for breast cancer resembling the same clinical characteristics as seen in patients affected by normal pressure hydrocephalus. The symptoms had been observed for about 2 years as having been caused only by polyneuropathy, given the high incidence of this side effect and the accompanying numbness of distal extremities. However, brain MRI evidenced a marked enlargement of the ventricular system. Brain metastases as well as carcinomatous meningitis were ruled out. After having placed a ventriculoperitoneal shunt, the patient showed a rapid, long-lasting and outstanding improvement of gait performance. We discuss the coexistence, in this case, of taxane-associated hydrocephalus and polyneuropathy and describe the clinical features, assessment and surgical outcome of docetaxel-induced hydrocephalus, since its early recognition and differentiation from the highly frequent taxane-associated polyneuropathy has relevant consequences for the management and treatment of these patients.

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Effects of anticancer drug docetaxel on the structure and function of the rabbit olfactory mucosa

Cited by 7 publications

References 88 publications

The Role of Primary Cilia in Thyroid Cancer: From Basic Research to Clinical Applications

The Role of Primary Cilia in Thyroid Cancer: From Basic Research to Clinical Applications

Identification of drugs that restore primary cilium expression in cancer cells

A Rare Case of Docetaxel-Induced Hydrocephalus Presenting with Gait Disturbances Mimicking and Coexisting with Taxane-Associated Polyneuropathy: The Relevance of Differential Diagnosis, Clinical Assessment, and Response to Ventriculoperitoneal Shunt

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