Effects of Anti-erectile Dysfunction Drug on some Key Tissues in Healthy Male Rats

Akintunde, J. K.; Ajiboye, John A.; Siemuri, E.O.; Oyelowo, S.B.; Sunday, Ogbodo; Abam, Esther Omugha; Irondi, A.E.

doi:10.3923/ajdd.2013.32.46

Cited by 3 publications

(7 citation statements)

References 24 publications

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“…Co-administration of lisinopril with GAR and SACE did not significantly improve the protein content. This in part shows that the decrease in protein content in rats treated with lisinopril may not be due to oxidative stress, but through the direct inhibitory effect of lisinopril on protein synthesis [34] .…”

Section: Discussionmentioning

confidence: 98%

Research on garlic capsule and selenium-vitamin A, vitamin B, vitamin C applied in therapy of acute hepatocellular damage in a rat model

Akintunde

Bolarin

2015

Journal of Acute Disease

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A B S T R A C TObjectives: To evaluate the toxicity of lisinopril in liver of male rats and its reversal effect of garlic capsule (GAR) and selenium-vitamin A, vitamin B, vitamin C (SACE). Methods: Thirty five adult male wistar rats were randomly assigned into 5 groups of 7 animals per group. Group I serves as the control, animals in Groups II, III, IV and V received 28 mg/kg body weight of lisinopril via oral route. Group III was co-treated with GAR at therapeutic dose of 250 mg/kg body weight per day. Group IV was co-treated with SACE at dose of 500 mg/kg body weight. Lastly, group V was co-treated with GAR and SACE at doses of 250 and 500 mg/kg body weight respectively, and the experiment last for 8 days.Results: Administration of lisinopril caused systemic toxicity in liver as well as adverse histopathologic changes in the tested tissue. While GAR and SACE significantly (P < 0.05) reversed the toxic effects induced by lisinopril. Conclusions: Collectively, the results suggest that therapeutic dose of lisinopril elicits toxicity in male rats through induction of oxidative damage and depletion of cellular adenosine triphosphate. The reversal effects of GAR and SACE during lisinopril treatment suggest that these antioxidants may find clinical application in cellular damage involving ROS and adenosine triphosphate.

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Section: Discussionmentioning

confidence: 98%

Research on garlic capsule and selenium-vitamin A, vitamin B, vitamin C applied in therapy of acute hepatocellular damage in a rat model

Akintunde

Bolarin

2015

Journal of Acute Disease

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“…Group-I Wistar rats fed on a standard pelletized rat chow (control group) + water ad libitum Group II Wistar rats fed on 50% African yam bean seed meal + water ad libitum Group III Wistar rats fed on 100% African yam bean seed meal + water ad libitum Group IV Wistar rats fed on 50% African yam bean tuber meal + water ad libitum Group-V Wistar rats fed on 100% African yam bean tuber meal + water ad libitum Humane care was given to the experimental rats following the advice given in the Guidelines for the Care and Use of Laboratory Animals [23,30]. Seventy-two hours after administration of the treatments, the rats were sacrificed using light ether anesthesia.…”

Section: Treatment Of Animalsmentioning

confidence: 99%

“…e organs harvested from the rats were homogenized in 50 Mm Tris HCL buffer (pH 7.4) which contained 1.15% KCL, and the homogenate was centrifuged at 10,000 g for 15 min at 4°C [23]. e supernatant was collected, and catalase (CAT) activity was estimated using hydrogen peroxide as a substrate [23].…”

Section: Antioxidant Assaysmentioning

confidence: 99%

“…e three organs from the Wistar rats (kidney, liver, and testis) were sliced in bits and prepared by fixing in Bouin's fixative for 6 h [23], followed by treatment with formalin. e tissues were, then, sectioned and stained with hematoxylin and eosin for histopathological examination [23]. A light microscope was used to produce stable photomicrographs.…”

Section: Histopathological Analysismentioning

confidence: 99%

“…All the results are expressed as means ± standard deviation (SD) with six rats per group. Statistical Analysis Software version 9.3 was used for the analyses 9.3 [23,35].…”

Section: Statisticalmentioning

confidence: 99%

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Biochemical and Histopathological Studies of Key Tissues in Healthy Male Wistar Rats Fed on African Yam Bean Seed and Tuber Meals

Ojuederie

Ajiboye

Babalola

2020

Journal of Food Quality

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Food insecurity and malnutrition are currently major issues affecting most developing countries, especially on the African continent. To mitigate this effect, focus is being given to orphan or underutilized crops with immense potentials to boost food and nutrition security in Africa, such as the African yam bean (AYB) Sphenostylis stenocarpa. The effect of AYB seed and tuber meals on the tissues of the kidney, liver, and testis of healthy male Wistar rats were investigated in this study. Four accessions of AYB were used for this study, TSs 107, TSs 140, AYB 45, and AYB 57. Thirty rats were randomly assigned into five groups (n = 6). Group I was fed on standard pelletized rat chow (control), Group II fed on 50% seed meal, Group III fed on 100% seed meal, Group IV fed on 50% tuber meal, and Group-V fed on 100% tuber meal. At the end of the treatments, the animals were sacrificed after 72 h under light ether anesthesia, and biochemical and histopathological analyses were conducted on the tissues. Phytate concentration was higher in the seeds (TSs140 (550 mg 100g−1), AYB45 (460 mg 100g−1), and AYB57 (485 mg 100g−1)) compared to the tubers (TSs140 (14.8 mg 100g−1), AYB 45 (275 mg 100g−1), and AYB57 (240 mg 100g−1)). The consumption of 100% unprocessed AYB seeds caused liver and kidney damage in rats due to increased levels of aspartate aminotransferase (5.04 ± 1.62 U L−I), alanine aminotransferase (8.46 ± 2.43 U L−I), and lipid peroxidation (0.27 ± 0.02-unit mg−1protein). AYB tubers were innocuous to Wistar rats investigated. Good processing of AYB seeds is required for safe consumption by humans and livestock. This study has shown that tubers of AYB are safe for human consumption and should be utilized in meals as it contains fewer antinutrients and had no significant effect on the tissues examined in Wistar rats.

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Effects of sub-acute methanol extract treatment of Calliandra portoricensis root bark on antioxidant defence capacity in an experimental rat model

Siemuri

Akintunde

Salemcity

2014

Journal of Basic and Clinical Physiology and Pharmacology

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Effects of Anti-erectile Dysfunction Drug on some Key Tissues in Healthy Male Rats

Cited by 3 publications

References 24 publications

Research on garlic capsule and selenium-vitamin A, vitamin B, vitamin C applied in therapy of acute hepatocellular damage in a rat model

Research on garlic capsule and selenium-vitamin A, vitamin B, vitamin C applied in therapy of acute hepatocellular damage in a rat model

Biochemical and Histopathological Studies of Key Tissues in Healthy Male Wistar Rats Fed on African Yam Bean Seed and Tuber Meals

Effects of sub-acute methanol extract treatment of Calliandra portoricensis root bark on antioxidant defence capacity in an experimental rat model

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