Effects of Anthocyanin on Serum Lipids in Dyslipidemia Patients: A Systematic Review and Meta-Analysis

Abstract

BackgroundDyslipidemia was present in most of the patients with coronary heart disease. Epidemiological evidence suggests that anthocyanin has some effects on the serum lipid. However, these results are controversial. This study aimed at collecting current clinical evidence and evaluating the effects of anthocyanin supplementation on total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in dialysis patients.MethodsThe search included PubMed, Web of Science, MEDLINE, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database (up to July 2015) to identify randomized controlled trials (RCTs) on the association between anthocyanin and serum lipids. RevMan (version 5.2) was used for Meta-analysis. Meta-regression analysis, sensitivity analysis and Egger’s weighted regression tests were performed by using STATA software (version 12.0; StatCorp, College Station, TX, USA).ResultsSix studies (seven arms) involving 586 subjects were included in this meta-analysis. The results showed that anthocyanin supplementation has significant effects on TC [MD = -24.06, 95% CI(-45.58 to -2.64) mg/dL, I2 = 93%], TG [MD = -26.14, 95%CI(-40.20 to -3.08) mg/dL, I2 = 66%1], LDL-C [MD = -22.10, 95% CI (-34.36 to -9.85) mg/dL, I2 = 61%], and HDL-C(MD = 5.58, 95% CI (1.02 to 10.14) mg/dL;I2 = 90%).ConclusionAnthocyanin supplementation significantly reduces serum TC, TG, and LDL-C levels in patients with dyslipidemia, and increases HDL-C. Further rigorously designed RCTs with larger sample sizes are needed to confirm the effectiveness of anthocyanin supplementation for dyslipidemia, especially hypo high density lipoprotein cholesterolemia.

Effects of purified anthocyanin supplementation on platelet chemokines in hypocholesterolemic individuals: a randomized controlled trial

“…In addition, platelet chemokines are produced following stimulation of TNF-α and IL-1β [68], which result in recruitment of leukocytes to the site of vascular injury and enhancement of inflammatory processes. Recently, some studies have revealed that anthocyanin supplementation significantly reduces the serum lipid [69] and pro-inflammatory cytokine levels [70–72], consistent with the effects of anthocyanins observed in our previous studies [32, 35]. In the present study, we first revealed that the reductions in the platelet chemokine levels caused by anthocyanins were positively correlated with the changes in the inflammatory marker and blood lipid levels.…”

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

“…For example, systematic reviews of the effects of interventions with ANCs on lipid biomarkers have reported that only ANCs cause significant reductions in LDL-C in participants with hypercholesterolemia (4 out of 4 studies), but not in participants who had normal cholesterol (zero out of 8 studies) [172]. It was also reported that ANCs supplementation significantly decreased T-C, TAGs, LDL-C and increased HDL-C in dyslipidemic patients (6 studies including 586 subjects [173]. Similarly, it has been reported that high-dose quercetin supplementation caused a significant reduction in blood pressure in stage 1 hypertensive participants but was not affected in pre-hypertensive participants [174].…”

Effect of Anthocyanin Supplementations on Lipid Profile and Inflammatory Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…Though having similarities in terms of TC and LDL level we have also assessed effect of anthocyanins on HDL, TG, apolipoprotein A-1 and B, and inflammatory markers. Similarly, even Liu et al [9] have published the effect of anthocyanins on serum lipid levels in exclusive dyslipidemic patients; in contrast to them we have included all the population including healthy adults and assessed impact of purified or dietary supplementations on lipid levels. We found that results of our meta-analysis are far more reliable as Egger's regression and Begg and Mazumdar rank correlation test showed no publication bias for all the parameters.…”

“…However, the efficacy studies of natural phenolic compounds are often subjected to criticism regarding dosage standardization and reproducibility of their effects in various health conditions. Similarly in general, all studies favour the supplementation of anthocyanin for improvement of lipid profile in healthy, diabetic, and populations at risk of CVD, although some studies have failed to report any significant improvement or reported varying degrees of improvement in various dyslipidemias and inflammatory markers with therapeutic intervention of anthocyanins [9]. We herewith investigated the cumulative evidence from 17 randomized controlled trials (RCT) [10–27] for the association of anthocyanin consumption (either dietary sources or supplements) with levels of various lipid and inflammatory markers.…”