Effects of antenatal micronutrient supplementation regimens on adolescent emotional and behavioral problems: A 14-year follow-up of a double-blind, cluster-randomized controlled trial

Zhu, Zhonghai; Zhu, Yingze; Wang, Liang; Qi, Qi; Hua, Lin; Andegiorgish, Amanuel Kidane; Elhoumed, Mohamed; Cheng, Yue; Dibley, Michael J.; Sudfeld, Christopher R.; Zeng, Lingxia

doi:10.1016/j.clnu.2022.12.001

Cited by 5 publications

(9 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a 14-year follow-up trial conducted in China, it was found that MMS had a signi cantly more favorable impact on behavior problem scores in a uent households, exhibiting a score difference of -6.61 (95% CI -11.70, -1.52) compared to the IFAS group. Similar observations were made for externalizing behavior, social problems, rule-breaking behaviors, and aggressive behavior scores [30].…”

Section: Child Emotional and Behavioral Problemssupporting

confidence: 72%

The impact of antenatal multiple micronutrient supplementation on child growth and cognitive advancement: a systematic review and meta-analysis

Chao,

Shen,

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Receiving multiple micronutrient supplementations (MMS) in developing countries has demonstrated favorable effects on birth outcomes. The objective of this review is to assess the effectiveness of MMS interventions in relation to the long-term physical and cognitive development of children. Methods We conducted a comprehensive search for eligible studies through databases in May 2023. Meta-analyses were conducted using Stata, version 15, on all randomized controlled trials (RCTs) that evaluated the long-term developmental outcomes of children by assessing the impact of preconceptional and antenatal MMS. Results The review encompassed a total of twelve studies. The trials included a total of 13,899 pregnant women and 12,986 children, serving as the foundation for individual participant data meta-analyses MMS involving iron plus folic acid supplementation (IFAS). Our analysis revealed that MMS did not demonstrate any significant improvements in key anthropometric and body composition measurements, including weight-for-age z score (WAZ) (Mean Difference [MD]: 0.01; 95% Confidence Interval [CI]: -0.05 to 0.07), height-for-age z score (HAZ) (MD: 0.00; 95% CI: -0.05 to 0.05), Body Mass Index (BMI)-for-age (MD: 0.04; 95% CI: -0.04 to 0.12), weight-for-length z score (WLZ) (MD: 0.00; 95% CI: -0.07 to 0.08), head circumference (HC) (MD: 0.06; 95% CI: -0.05 to 0.17), and mid-upper arm circumference (MUAC) (MD: 0.04; 95% CI: -0.04 to 0.12). However, the administration of prenatal MMS exhibited a significant positive correlation with the enhancement of children's Full Scale Intelligence Quotient (FSIQ) scores (MD: 0.97, 95% CI: 0.09 to 1.84). Conclusions The antenatal maternal MMS interventions do not appear to have a discernible impact on child growth outcomes. However, there is potential evidence suggesting that maternal MMS interventions may positively influence the cognitive development of offspring. Trial registration: CRD42023428221 (31/05/2023)

show abstract

Section: Child Emotional and Behavioral Problemssupporting

confidence: 72%

The impact of antenatal multiple micronutrient supplementation on child growth and cognitive advancement: a systematic review and meta-analysis

Chao,

Shen,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…[ 8 , 9 ] These effects also seem to persist into adolescence, as seen in a 14-year follow-up of a large randomized controlled trial (RCT) from rural China, which compared multiple micronutrient (MMN) supplementation, IFA supplementation, and folic acid supplementation alone, which found that the MMN and IFA groups showed improved measures of intellectual development[ 10 ] and also reduced levels of total and externalizing psychopathology. [ 11 ]…”

Section: Preventive Interventions For Sudmentioning

confidence: 99%

Mental health and well-being for the prevention of substance use disorders

Mahadevan,

Gautam,

Benegal

2024

Indian Journal of Psychiatry

View full text Add to dashboard Cite

“…A newer line of research is investigating the effects of supplementation with vitamins and minerals (broad spectrum As far as we are aware, there is no literature on the relation between antenatal nutrient supplementation with BSM and infant temperament; however, there is significant evidence for the benefits of nutrient supplementation in pregnancy for overall infant development (51-53). The effects of antenatal supplementation with single nutrients such as folic acid, iron and iodine on infant outcomes although mixed, report improvements in birth outcomes (53), cognitive and motor performance in the first year (54,55) and reduced behavioral problems later in life (56,57). Despite these improvements, there are some reports of detrimental effects to infant outcomes related to excessive supplementation with one nutrient given over the recommended dietary allowance (58)(59)(60).…”

Section: Introductionmentioning

confidence: 99%

Exploring the impact of antenatal micronutrients used as a treatment for maternal depression on infant temperament in the first year of life

Campbell,

Dys,

Henderson

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

Antenatal depression and maternal nutrition can influence infant temperament. Although broad-spectrum-micronutrients (BSM: vitamins and minerals) given above Recommended Dietary Allowances during pregnancy can mitigate symptoms of antenatal depression, their associated effects on infant temperament are unknown. One hundred and fourteen New Zealand mother-infant dyads (45 infants exposed to BSM during pregnancy (range of exposure during pregnancy: 12–182 days) to treat antenatal depressive symptoms (measured by Edinburgh Postnatal Depression Scale) and 69 non-exposed infants) were followed antenatally and for 12 months postpartum to determine the influence of in utero BSM exposure on infant temperament. The Infant Behavior Questionnaire–Revised: Very Short-Form assessed temperament at 4 (T1), 6 (T2) and 12 (T3) months postpartum via online questionnaire. Latent growth curve modeling showed BSM exposure, antenatal depression and infant sex did not statistically significantly predict initial levels or longitudinal changes in orienting/regulatory capacity (ORC), positive affectivity/surgency (PAS) or negative affectivity (NEG). Higher gestational age was positively associated with initial PAS, and smaller increases between T1 and T3. Breastfeeding occurrence was positively associated with initial NEG. Although not significant, BSM exposure exerted small, positive effects on initial NEG (β = −0.116) and longitudinal changes in ORC (β = 0.266) and NEG (β = −0.235). While BSM exposure did not significantly predict infant temperament, it may mitigate risks associated with antenatal depression. BSM-exposed infants displayed temperamental characteristics on par with typical pregnancies, supporting the safety of BSM treatment for antenatal depression.

show abstract

Effects of antenatal micronutrient supplementation regimens on adolescent emotional and behavioral problems: A 14-year follow-up of a double-blind, cluster-randomized controlled trial

Cited by 5 publications

References 45 publications

The impact of antenatal multiple micronutrient supplementation on child growth and cognitive advancement: a systematic review and meta-analysis

The impact of antenatal multiple micronutrient supplementation on child growth and cognitive advancement: a systematic review and meta-analysis

Mental health and well-being for the prevention of substance use disorders

Exploring the impact of antenatal micronutrients used as a treatment for maternal depression on infant temperament in the first year of life

Contact Info

Product

Resources

About