Effects of antenatal glucocorticoids on outcomes of very low birth weight multifetal gestations

Hashimoto, Laura Nickles; Hornung, Richard; Lindsell, Christopher J.; Brewer, David E.; Donovan, Edward F.

doi:10.1067/mob.2002.125891

Cited by 28 publications

(14 citation statements)

References 17 publications

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“…A recent study by Blickstein et al , involving 2460 twins and 906 triplets, proved that a complete course of ACS significantly reduces the risk of RDS in multiples . Similar results have also been published by other authors . Based on those results, ACS are recommended in women with multiple pregnancy and threatened preterm labor.…”

Section: Introductionsupporting

confidence: 62%

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Relation between time interval from antenatal corticosteroids administration to delivery and neonatal outcome in twins

Kosińska-Kaczyńska

Szymusik

Urban

et al. 2016

J of Obstet and Gynaecol

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Section: Introductionsupporting

confidence: 62%

“…5 Similar results have also been published by other authors. [6][7][8][9][10] Based on those results, ACS are recommended in women with multiple pregnancy and threatened preterm labor.…”

Section: Introductionmentioning

confidence: 99%

Relation between time interval from antenatal corticosteroids administration to delivery and neonatal outcome in twins

Kosińska-Kaczyńska

Szymusik

Urban

et al. 2016

J of Obstet and Gynaecol

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“…They have consistently found that multiple-gestations respond as singletons, but one study suggested that this was only true if the duration of antenatal sGC therapy optimally occurred between 2 and 7 days after maternal administration 20 . In addition, very low birth weight multiple gestation infants exposed to ACS may respond as well as their singleton counterparts 24 , but it is not clear if this applies to exposure out of the optimal window for delivery.…”

Section: Demographic Variables In the Response To Antenatal Sgc Therapymentioning

confidence: 99%

Effects of antenatal glucocorticoids on the developing brain

et al. 2016

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Glucocorticoids (GCs) regulate distinct physiological processes in the developing fetus, in particular accelerating organ maturation that enables the fetus to survive outside the womb. In preterm birth, the developing fetus does not receive sufficient exposure to endogenous GCs in utero for proper organ development predisposing the neonate to complications including intraventricular hemorrhage, respiratory distress syndrome (RDS) and necrotizing enterocolitis (NEC). Synthetic GCs (sGCs) have proven useful in the prevention of these complications since they are able to promote the rapid maturation of underdeveloped organs present in the fetus. While these drugs have proven to be clinically effective in the prevention of IVH, RDS and NEC, they may also trigger adverse developmental side effects. This review will examine the current clinical use of antenatal sGC therapy in preterm birth, their placental metabolism, and their effects on the developing brain.

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“…Older observational studies in twins/multiples have mainly investigated the effect of ANS on respiratory distress syndrome, with inconsistent results: some found protection; others found no protective effect, while still others found some effect . Blickstein and colleagues also studied the effect of ANS against IVH and found that while complete courses afforded protection against IVH, partial courses did not, and there was no difference between singletons, twins, and higher‐order multiples …”

Section: Commentmentioning

confidence: 99%

“…5 Despite more than 40 years of research, the efficacy of steroids in multiple pregnancies has not been rigorously tested in randomised clinical trials, 4,6 and results from observational studies are conflicting. [7][8][9][10][11][12][13][14][15][16][17][18][19][20] Recently, a large observational study among extremely preterm infants of 22-28 weeks' gestation suggested that ANS reduce mortality in multiples overall. 18 However, small for gestational age (SGA) multiples faced a higher risk of death or neurodevelopmental impairment when treated with ANS.…”

Section: Introductionmentioning

confidence: 99%