Effects of Anodal Transcranial Direct Current Stimulation on Chronic Neuropathic Pain in Patients With Multiple Sclerosis

Mori, Francesco; Codecà, C.; Kusayanagi, Hajime; Monteleone, Fabrizia; Buttari, Fabio; Fiore, Stefania; Bernardi, Giorgio; Koch, Giacomo; Centonze, Diego

doi:10.1016/j.jpain.2009.08.011

Cited by 220 publications

(201 citation statements)

References 39 publications

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“…Minimal clinically important difference (MCID) in pain reduction on a numerical analog scale (0-10) ranges from~1.5 23 to 1.8, 24 whereas the current meta-analysis found a pooled decrease of 1.33 units at end of treatment. These findings are consistent with previous reviews examining the effect of tDCS among chronic pain 25 and multiple sclerosis 26 populations.…”

Section: Discussionsupporting

confidence: 92%

Effectiveness of transcranial direct current stimulation for the management of neuropathic pain after spinal cord injury: a meta-analysis

et al. 2015

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Objectives: To conduct a systematic review and meta-analysis to examine the effect of transcranial direct current stimulation (tDCS) on reducing neuropathic pain intensity in individuals with spinal cord injury (SCI). Methods: Medline, CINAHL, EMBASE and PsycINFO databases were searched for all relevant articles published from 1980 to November 2014. Trials were included if (i) tDCS intervention group and a placebo control group were present; (ii) at least 50% of participants in the study had an SCI and there were at least three participants; (iii) participants were aged 18 years or older; and (iv) persistent pain for at least 3 months. Studies were excluded if: (i) the tDCS intervention group was compared with an active treatment group; (ii) there was insufficient reporting detail to enable pooling of data; and (iii) it was a nonclinical trial (that is, reviews, epidemiology, basic sciences). A standardized mean difference (SMD) ± s.e. and 95% confidence interval (CI) was calculated for each outcome of interest and the results were pooled using a fixed or random effects model, as appropriate. Effect sizes were interpreted as: small 40.2, moderate 40.5, large 40.8. Results: Five studies met inclusion criteria of which four were randomized controlled trials and one was a prospective controlled trial. The pooled analysis found a significant effect of tDCS on reducing neuropathic pain after SCI post treatment (SMD = 0.510 ± 0.202; 95% CI, 0.114-0.906; Po0.012); however, this effect was not maintained at follow-up (SMD = 0.353 ± 0.272; 95% CI, − 0.179 to 0.886; Po0.194). A reduction of 1.33 units on a 10-item scale was observed post treatment. No significant adverse events were reported. Conclusion: Meta-analytic results indicate a moderate effect of tDCS in reducing neuropathic pain among individuals with SCI; however, the effect was not maintained at follow-up. A mean pooled decrease of 1.33 units on a 10-item scale was found post treatment. Several factors were implicated in the effectiveness of tDCS in reducing pain. Due to the limited number of studies and lack of follow-up, more evidence is required before treatment recommendations can be made. Spinal Cord (2015) 53, 780-785; doi:10.1038/sc.2015.118; published online 21 July 2015 INTRODUCTIONChronic neuropathic pain (NP) can occur following lesions in the somatosensory nervous system 1 and incidence rates range from~50 2,3 to 75-81%. 4,5 Several treatments have been proposed and used to manage NP, particularly pharmacological methods (for example, antidepressants, anticonvulsants, opioids). 6,7 Despite multiple pharmacological options for pain, the majority of individuals fail to find relief; the refractory nature of NP is what makes it such a difficult condition to treat and to endure. Studies have shown that refractory NP is common post SCI 8 and that few (4-6%) obtain relief over the long-term. 9 This situation has created interest in alternative neuromodulary stimulation approaches such as cranial electrotherapy stimulation, transcutaneous electrical nerve ...

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Section: Discussionsupporting

confidence: 92%

Effectiveness of transcranial direct current stimulation for the management of neuropathic pain after spinal cord injury: a meta-analysis

et al. 2015

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“…Of the 12 RCTs, 3 (25%) had active comparison groups 26-28 and 9 (75%) had sham treatment [29][30][31][32][33][34][35][36] or no intervention control groups. 37 The number of intervention sessions ranged from 10 to 112 33 over 5 days 29,32,36 to 24 weeks.…”

Section: Electrical Stimulation Interventionsmentioning

confidence: 99%

“…37 The number of intervention sessions ranged from 10 to 112 33 over 5 days 29,32,36 to 24 weeks. 28 The duration of each session ranged from 15 minutes 32,36 to 24 hours.…”

Section: Electrical Stimulation Interventionsmentioning

confidence: 99%

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Effect of Comorbidities on Outcomes of Neurorehabilitation Interventions in Multiple Sclerosis

Fakolade¹,

Bisson²,

Pétrin³

et al. 2016

International Journal of MS Care

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“…La tDCS anodique permettrait de diminuer l'inhibition intracorticale et, de ce fait, modifierait l'excitabilité corticocorticale impliqué e dans les sensations douloureuses. Plus ré cemment, une é tude a é galement montré l'effet positif de la tDCS sur les algies de patients souffrant de la sclé rose en plaques (Mori et al, 2010). Comme pour les é tudes pré -cé dentes, une augmentation du seuil de douleur a é té objectivé e à la suite d'une semaine de stimulations.…”

Section: Effets Antalgiquesunclassified

La stimulation transcrânienne à courant continu : un nouvel outil de neurostimulation

Thibaut¹,

Chatelle²,

Gosseries³

et al. 2013

Revue Neurologique

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Effects of Anodal Transcranial Direct Current Stimulation on Chronic Neuropathic Pain in Patients With Multiple Sclerosis

Cited by 220 publications

References 39 publications

Effectiveness of transcranial direct current stimulation for the management of neuropathic pain after spinal cord injury: a meta-analysis

Effectiveness of transcranial direct current stimulation for the management of neuropathic pain after spinal cord injury: a meta-analysis

Effect of Comorbidities on Outcomes of Neurorehabilitation Interventions in Multiple Sclerosis

La stimulation transcrânienne à courant continu : un nouvel outil de neurostimulation

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