Effects of anodal transcranial direct current stimulation (tDCS) on behavioral and spatial memory during the early stage of traumatic brain injury in the rats

Yoon, Kyung Jae; Lee, Yong Taek; Chae, Seoung Wan; Park, Chae Ri; Kim, Dae Yul

doi:10.1016/j.jns.2016.02.005

Cited by 34 publications

(33 citation statements)

References 37 publications

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“…Traumatic brain injury is not a common disease that is treated by tDCS because of seizure tendency. However, Yoon et al applied anodal tDCS in traumatic brain injury and showed a therapeutic effect [16]. Similar to Yoon's study, our study showed the potential of anodal tDCS treatment on rmTBI.…”

Section: Discussionsupporting

confidence: 87%

“…The accumulation and repetition of decreased cortical excitability would extend the behavioral change, and then, anodal tDCS could be a novel management option for behavioral impairment resulting from rmTBI if further long-term study supports our results. A recent study proved that anodal tDCS applied during the early stage of traumatic brain injury had a beneficial effect on behavioral and spatial memory [16]. Traumatic brain injury is not a common disease that is treated by tDCS because of seizure tendency.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that anodal tDCS provides a therapeutic effect in patients with neurologic disorders, such as stroke, Parkinson's disease, and Alzheimer's disease [13–15]. A recent study showed that anodal tDCS improves spatial memory during the early stage of traumatic brain injury in rats [16]. But, there is still no study assessing the effect of anodal tDCS on rmTBI.…”

Section: Introductionmentioning

confidence: 99%

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Anodal Transcranial Direct Current Stimulation Provokes Neuroplasticity in Repetitive Mild Traumatic Brain Injury in Rats

Kim

Han

2017

Neural Plasticity

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Repetitive mild traumatic brain injury (rmTBI) provokes behavioral and cognitive changes. But the study about electrophysiologic findings and managements of rmTBI is limited. In this study, we investigate the effects of anodal transcranial direct current stimulation (tDCS) on rmTBI. Thirty-one Sprague Dawley rats were divided into the following groups: sham, rmTBI, and rmTBI treated by tDCS. Animals received closed head mTBI three consecutive times a day. Anodal tDCS was applied to the left motor cortex. We evaluated the motor-evoked potential (MEP) and the somatosensory-evoked potential (SEP). T2-weighted magnetic resonance imaging was performed 12 days after rmTBI. After rmTBI, the latency of MEP was prolonged and the amplitude in the right hind limb was reduced in the rmTBI group. The latency of SEP was delayed and the amplitude was decreased after rmTBI in the rmTBI group. In the tDCS group, the amplitude in both hind limbs was increased after tDCS in comparison with the values before rmTBI. Anodal tDCS after rmTBI seems to be a useful tool for promoting transient motor recovery through increasing the synchronicity of cortical firing, and it induces early recovery of consciousness. It can contribute to management of concussion in humans if further study is performed.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anodal Transcranial Direct Current Stimulation Provokes Neuroplasticity in Repetitive Mild Traumatic Brain Injury in Rats

Kim

Han

2017

Neural Plasticity

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“…Transcranial direct current stimulation was used to improve various functional measures in Parkinson's disease (Kaski et al, 2010; Manenti et al, 2014), stroke (Boggio et al, 2007; Di Lazzaro et al, 2014; Meinzer et al, 2016; Valiengo et al, 2016), and traumatic brain injury (Kang et al, 2012; Yoon et al, 2016). This technique has been tested in humans as well as monkey and rats (Baker et al, 1995; Notturno et al, 2014; Lee et al, 2015; Sellers et al, 2015; Yoon et al, 2016).…”

Section: Interhemispheric Connectivity In Dbs Studiesmentioning

confidence: 99%

“…This technique has been tested in humans as well as monkey and rats (Baker et al, 1995; Notturno et al, 2014; Lee et al, 2015; Sellers et al, 2015; Yoon et al, 2016). Similar to TMS studies discussed in earlier sections, the alteration in interhemispheric interaction following these disease states can be investigated also by using tDCS.…”

Section: Interhemispheric Connectivity In Dbs Studiesmentioning

confidence: 99%

Novel Neuromodulation Techniques to Assess Interhemispheric Communication in Neural Injury and Neurodegenerative Diseases

Shin

Pelled

2017

Front. Neural Circuits

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Interhemispheric interaction has a major role in various neurobehavioral functions. Its disruption is a major contributor to the pathological changes in the setting of brain injury such as traumatic brain injury, peripheral nerve injury, and stroke, as well as neurodegenerative diseases. Because interhemispheric interaction has a crucial role in functional consequence in these neuropathological states, a review of noninvasive and state-of-the-art molecular based neuromodulation methods that focus on or have the potential to elucidate interhemispheric interaction have been performed. This yielded approximately 170 relevant articles on human subjects or animal models. There has been a recent surge of reports on noninvasive methods such as transcranial magnetic stimulation and transcranial direct current stimulation. Since these are noninvasive techniques with little to no side effects, their widespread use in clinical studies can be easily justified. The overview of novel neuromodulation methods and how they can be applied to study the role of interhemispheric communication in neural injury and neurodegenerative disease is provided. Additionally, the potential of each method in therapeutic use as well as investigating the pathophysiology of interhemispheric interaction in neurodegenerative diseases and brain injury is discussed. New technologies such as transcranial magnetic stimulation or transcranial direct current stimulation could have a great impact in understanding interhemispheric pathophysiology associated with acquired injury and neurodegenerative diseases, as well as designing improved rehabilitation therapies. Also, advances in molecular based neuromodulation techniques such as optogenetics and other chemical, thermal, and magnetic based methods provide new capabilities to stimulate or inhibit a specific brain location and a specific neuronal population.

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Effects of transcranial direct current stimulation on the glutamatergic pathway in the male rat hippocampus after experimental focal cerebral ischemia

Akçay,

Aslan,

Kipmen Korgun

et al. 2023

J of Neuroscience Research

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This study aimed to assess the focal cerebral ischemia‐induced changes in learning and memory together with glutamatergic pathway in rats and the effects of treatment of the animals with transcranial Direct Current Stimulation (tDCS). One hundred male rats were divided into five groups as sham, tDCS, Ischemia/Reperfusion (IR), IR + tDCS, and IR + E‐tDCS groups. Learning, memory, and locomotor activity functions were evaluated by behavioral experiments in rats. Glutamate and glutamine levels, alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionate receptor (AMPAR1), N‐Methyl‐D‐Aspartate receptors (NMDAR1 and NMDAR2A), vesicular glutamate transporter‐1 (VGLUT‐1), and excitatory amino acid transporters (EAAT1‐3) mRNA expressions in hippocampus tissues were measured. Ischemic areas were analyzed by TTC staining. The increase was observed in IR + tDCS, and IR + E‐tDCS groups compared to the IR group while a significant decrease was observed in IR group compared to the sham in the locomotor activity, learning, and memory tests. While glutamate and glutamine levels, AMPAR1, NMDAR1, NMDAR2A, VGLUT1, and EAAT1 mRNA expressions were significantly higher in IR group compared to the sham group, it was found to be significantly lower in IR + tDCS and IR + E‐tDCS groups compared to the IR group. EAAT2 and EAAT3 mRNA expressions were significantly higher in IR + tDCS and IR + E‐tDCS groups compared to the IR group. Ischemic areas were significantly decreased in IR + tDCS and IR + E‐tDCS groups compared to the IR group. Current results suggest that tDCS application after ischemia improves learning and memory disorders and these effects of tDCS may be provided through transporters that regulate glutamate levels.

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Effects of anodal transcranial direct current stimulation (tDCS) on behavioral and spatial memory during the early stage of traumatic brain injury in the rats

Cited by 34 publications

References 37 publications

Anodal Transcranial Direct Current Stimulation Provokes Neuroplasticity in Repetitive Mild Traumatic Brain Injury in Rats

Anodal Transcranial Direct Current Stimulation Provokes Neuroplasticity in Repetitive Mild Traumatic Brain Injury in Rats

Novel Neuromodulation Techniques to Assess Interhemispheric Communication in Neural Injury and Neurodegenerative Diseases

Effects of transcranial direct current stimulation on the glutamatergic pathway in the male rat hippocampus after experimental focal cerebral ischemia

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