Effects of ankylosing spondylitis on cardiovascular disease: aMendelian randomization study
Lu Xiao,
Shudian Lin,
Feng Zhan
Abstract:ObjectiveAccumulating evidence suggests that patients with ankylosing spondylitis (AS) have an elevated risk for cardiovascular disease (CVD) and cardiovascular death, however, whether AS has causal effects on the risk of CVD is unclear.Two-sample Mendelian randomization (MR) was utilizedto examine the probable causal link between them.MethodsSummary statistics from publicly released genome-wide association studies (GWAS) was used to perform MR analyses. Genetically predicted AS was selected as the exposure va… Show more
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