Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle

Minami, Naoyoshi; Li, Yingyu; Guo, Qi; Kawamura, Takayuki; Mori, Nobuyoshi; Nagasaka, Makoto; Ogawa, Morimasa; Itoh, Osamu; Kurosawa, Hájíme; Kanazawa, Masayuki; Kohzuki, Masahiro

doi:10.1097/hjh.0b013e3280e126bf

Cited by 27 publications

(21 citation statements)

References 44 publications

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“…The activation of renin-angiotensin system, particularly the increase in angiotensin II (ANG II), has been well established to play an important role in the pathogenesis and progression of various cardiovascular diseases (7,15). Moreover, angiotensin-converting enzyme inhibitors have been shown to improve exercise capacity in patients with cardiovascular disease and in spontaneously hypertensive rats (5,22,34). These results suggest that ANG II may directly impair skeletal muscle function and reduce exercise capacity.…”

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confidence: 70%

Angiotensin II-induced reduction in exercise capacity is associated with increased oxidative stress in skeletal muscle

Inoue¹,

Kinugawa²,

Suga³

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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giotensin II (ANG II)-induced oxidative stress has been known to be involved in the pathogenesis of cardiovascular diseases. We have reported that the oxidative stress in skeletal muscle can limit exercise capacity in mice (16). We thus hypothesized that ANG II could impair the skeletal muscle energy metabolism and limit exercise capacity via enhancing oxidative stress. ANG II (50 ng·kg Ϫ1 ·min Ϫ1 ) or vehicle was infused into male C57BL/6J mice for 7 days via subcutaneously implanted osmotic minipumps. ANG II did not alter body weight, skeletal muscle weight, blood pressure, cardiac structure, or function. Mice were treadmill tested, and expired gases were analyzed. The work to exhaustion (vertical distance ϫ body weight) and peak oxygen uptake were significantly decreased in ANG II compared with vehicle. In mitochondria isolated from skeletal muscle, ADP-dependent respiration was comparable between ANG II and vehicle, but ADP-independent respiration was significantly increased in ANG II. Furthermore, complex I and III activities were decreased in ANG II. NAD(P)H oxidase activity and superoxide production by lucigenin chemiluminescence were significantly increased in skeletal muscle from ANG II mice. Treatment of ANG II mice with apocynin (10 mmol/l in drinking water), an inhibitor of NAD(P)H oxidase activation, completely inhibited NAD(P)H oxidase activity and improved exercise capacity, mitochondrial respiration, and complex activities in skeletal muscle. ANG II-induced oxidative stress can impair mitochondrial respiration in skeletal muscle and limit exercise capacity. mitochondria; reduced nicotinamide adenine dinucleotide phosphatase oxidase; oxygen uptake THE LIMITED EXERCISE CAPACITY represents a major symptom and an important prognostic factor in patients with cardiovascular disease and with risk factor for cardiovascular disease (19,24). The exercise capacity is generally believed to be limited in the presence of abnormalities in skeletal muscle, which include atrophy, transition of fiber type, and abnormal energy metabolism (6,26,30). The activation of renin-angiotensin system, particularly the increase in angiotensin II (ANG II), has been well established to play an important role in the pathogenesis and progression of various cardiovascular diseases (7, 15). Moreover, angiotensin-converting enzyme inhibitors have been shown to improve exercise capacity in patients with cardiovascular disease and in spontaneously hypertensive rats (5,22,34). These results suggest that ANG II may directly impair skeletal muscle function and reduce exercise capacity. However, the mechanisms by which ANG II induces skeletal muscle dysfunction remain unknown.ANG II leads to the production of superoxide (O 2 ·Ϫ ), the major reactive oxygen species (ROS), via NAD(P)H oxidase activation (2, 10). The production of O 2 ·Ϫ in skeletal muscle has been shown to be increased in the mouse model after myocardial infarction (31). In addition, our laboratory reported that the exercise capacity was decreased in heterozygous manganese ...

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mentioning

confidence: 70%

Angiotensin II-induced reduction in exercise capacity is associated with increased oxidative stress in skeletal muscle

Inoue¹,

Kinugawa²,

Suga³

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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“…Similarly, it was reported that the ACEIs combined with exercise improved in physical performance but there was no effect when used ACEIs alone in rodents [59][60][61]. However, Sumukadas et al showed that ACEIs did not enhance the effect of exercise training on physical function Total represents the total number of patients.…”

Section: Discussionmentioning

confidence: 91%

Effect of Angiotensin-Converting Enzyme Inhibitors on Physical Function in Elderly Subjects: A Systematic Review and Meta-Analysis

Zhou

Wang

et al. 2015

Drugs Aging

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“…The authors observed that chronic treatment with perindopril increases the exercise capacity in untrained animals; however, this effect was not synergic to the exercise capacity acquired as a result of ET alone. On the other hand, treatment with perindopril associated to ET promotes adaptive alterations in the soleus muscle, such as increase of capillary density and percentage of type I fibers 31 . Although no alteration in the composition of types of fiber was observed in the trained SHR and SHR treated with perindopril groups when compared with the sedentary SHR group, the authors observed higher capillarization in these groups, which may be attributed to improvement in the exercise capacity.…”

Section: Discussionmentioning

confidence: 99%

“…Minami et al 31 showed the effects of ET associated or not to treatment with perindopril (angiotensin-converting enzyme inhibitor), on the capillarity and fiber types in the soleus muscle of SHR. The authors observed that chronic treatment with perindopril increases the exercise capacity in untrained animals; however, this effect was not synergic to the exercise capacity acquired as a result of ET alone.…”

Section: Discussionmentioning

confidence: 99%

O treinamento físico aeróbio corrige a rarefação capilar e as alterações nas proporções dos tipos de fibra muscular esquelética em ratos espontaneamente hipertensos

Fernandes

Roque

Magalhães

et al. 2012

Rev Bras Med Esporte

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Aerobic exercise training (ET) has been established as an important non-pharmacological treatment of hypertension, since it decreases blood pressure. Studies show that the skeletal muscle abnormalities in hypertension are directly associated with capillary rarefaction, higher percentage of fast-twitch fibers (type II) with glycolytic metabolism predominance and increased muscular fatigue. However, little is known about these parameters in hypertension induced by ET. We hypothesized that ET corrects capillary rarefaction, potentially contributing to the restoration of the proportion of muscle fiber types and metabolic proprieties. Twelve-week old Spontaneously Hypertensive Rats (SHR, n=14) and Wistar Kyoto rats (WKY, n=14) were randomly assigned into 4 groups: SHR, trained SHR (SHR-T), WKY and trained WKY (WKY-T). As expected, ten weeks of ET was effective in reducing blood pressure in SHR-T group. In addition, we analyzed the main markers of ET. Resting bradycardia, increase of exercise tolerance, peak oxygen uptake and citrate synthase enzyme activity in trained groups (WKY-T and SHR-T) showed that the aerobic condition was achieved. ET also corrected the skeletal muscle capillary rarefaction in SHR-T. In parallel, we observed reduction in percentage of type IIA and IIX fibers and simultaneous augmented percentage of type I fibers induced by ET in hypertension. These data suggest that ET prevented changes in soleus fiber type composition in SHR, since angiogenesis and oxidative enzyme activity increased are important adaptations of ET, acting in the maintenance of muscle oxidative metabolism and fiber profile.

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Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle

Cited by 27 publications

References 44 publications

Angiotensin II-induced reduction in exercise capacity is associated with increased oxidative stress in skeletal muscle

Angiotensin II-induced reduction in exercise capacity is associated with increased oxidative stress in skeletal muscle

Effect of Angiotensin-Converting Enzyme Inhibitors on Physical Function in Elderly Subjects: A Systematic Review and Meta-Analysis

O treinamento físico aeróbio corrige a rarefação capilar e as alterações nas proporções dos tipos de fibra muscular esquelética em ratos espontaneamente hipertensos

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