Effects of angiotensin (5-8) microinfusions into the ventrolateral periaqueductal gray on defensive behaviors in rats

Angiotensin II Regulates the Neural Expression of Subjective Fear in Humans: A Precision Pharmaco-Neuroimaging Approach

“…Based on accumulating evidence from animal and human studies suggesting a role of the AT1R system in regulating fear-and threat-related processes (13,18,(39)(40)(41), we hypothesized that LT would reduce neural vigilance towards fearful oddballs as reflected by attenuated neural reactivity and connectivity in the fronto-limbic fear circuitry. Based on recent evidence suggesting that ATR1 blockade specifically modulates processing of threat-related -but not neutral or salient positive -stimuli (18,19,42), we expected that the neurofunctional decoding analyses would reveal specific effect of LT on the neural expression of subjective fear but not associated affective processes or neural reactivity towards novel oddballs.…”

Angiotensin II regulates the neural expression of subjective fear in humans - precision pharmaco-neuroimaging approach

“…Based on accumulating evidence from animal and human studies suggesting a role of the AT1R system in regulating fear-and threat-related processes (13,18,(39)(40)(41), we hypothesized that LT would reduce neural vigilance towards fearful oddballs as reflected by attenuated neural reactivity and connectivity in the fronto-limbic fear circuitry. Based on recent evidence suggesting that ATR1 blockade specifically modulates processing of threat-related -but not neutral or salient positive -stimuli (18,19,42), we expected that the neurofunctional decoding analyses would reveal specific effect of LT on the neural expression of subjective fear but not associated affective processes or neural reactivity towards novel oddballs.…”