Effects of Anethum graveolens (dill) and its derivatives on controlling cardiovascular risk factors: A systematic review and meta-analysis

Jalili, Cyrus; Moradi, Sajjad; Mirzababaei, Atieh; Mohammadi, Hamed; Heydarzadeh, Fatima; Miraghajani, Maryam; Lazaridi, Anastasia-Viktoria

doi:10.1016/j.hermed.2021.100516

Cited by 3 publications

(4 citation statements)

References 38 publications

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“…These include relatively small subject populations (n = 10-50); variable durations of intervention (4-12 weeks); the sources, dosages, and chemical contents of dill samples ingested; dissimilar health status of participants; and application of different statistical analyses. Each of 3 meta-analyses [36][37][38] addressed these findings by pooling data from specific selected trials. In the analyses of Jalili et al 36 and Mousavi et al, 37 significant decreases in fasting insulin levels (weighted mean difference [MD], −2.28 to −2.34 μU/mL) and in the homeostatic model assessment of insulin resistance (weighted MD, −1.06 to −1.07), compared with controls, were observed for those administered dill.…”

Section: Cardiovascular Disease and Type 2 Diabetes Mellitus (T2dm) R...mentioning

confidence: 99%

“…Each of 3 meta-analyses [36][37][38] addressed these findings by pooling data from specific selected trials. In the analyses of Jalili et al 36 and Mousavi et al, 37 significant decreases in fasting insulin levels (weighted mean difference [MD], −2.28 to −2.34 μU/mL) and in the homeostatic model assessment of insulin resistance (weighted MD, −1.06 to −1.07), compared with controls, were observed for those administered dill. No effect on fasting blood glucose was noted.…”

Section: Cardiovascular Disease and Type 2 Diabetes Mellitus (T2dm) R...mentioning

confidence: 99%

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Dill

Singletary¹

2023

Nutr Today

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Anethum graveolens L. (family Apiaceae) is an important culinary herb commonly called dill in English. This plant is native to southwest Asia and the Mediterranean region and is widely cultivated throughout Asia, Africa, Europe, Southern Russia, and the United States. The leaves, fruit, and essential oil of dill have numerous culinary uses, and the oil is a flavor additive in numerous products in the food industry such as dill pickles, processed meat, cheese, and bread. It is a perfume agent in detergents, soaps, fragrances, cosmetics, and mouthwashes. Dill has a long history of use in traditional medicines dating back thousands of years in China, Greece. and the Roman empire, particularly for relieving pain, indigestion, and anxiety. Recent clinical trials evaluated dill and its extracts for managing risk factors for diabetes and cardiovascular disease, as well as in improving outcomes during labor and delivery. This narrative summarizes these published human studies examining the potential health benefits of dill and highlights potential areas for further research.

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Section: Cardiovascular Disease and Type 2 Diabetes Mellitus (T2dm) R...mentioning

confidence: 99%

Section: Cardiovascular Disease and Type 2 Diabetes Mellitus (T2dm) R...mentioning

confidence: 99%

Dill

Singletary¹

2023

Nutr Today

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“…Dill (Anethum graveolens L.) is a spice belonging to the Apiaceae family. Owing to its low price and broad accessibility, dill is widely used in various dishes such as pickles, soups, sauces, seafood, grilled chicken, and steak . Using dill in dishes not only adds flavor but also promotes potential health benefits.…”

Section: Introductionmentioning

confidence: 99%

“…Owing to its low price and broad accessibility, dill is widely used in various dishes such as pickles, soups, sauces, seafood, grilled chicken, and steak. 1 Using dill in dishes not only adds flavor but also promotes potential health benefits. For instance, dill has been linked to health beneficial effects toward digestive diseases, insufficient lactation, respiratory problems, and glucose intolerance.…”

Section: Introductionmentioning

confidence: 99%

Chemical Compositions of Dill (Anethum graveolens L.) Water and Ethanol Extracts and Their Potential in Blocking the SARS-CoV-2 Entry into Cells and Free Radical Scavenging Capacities

Choe,

Li,

Liu

et al. 2023

ACS Food Sci. Technol.

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Dill (Anethum graveolens L.) is a spice belonging to the Apiaceae family and is widely used in various dishes. This study aims to evaluate dill's potential in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infiltration and alleviating coronavirus disease (COVID-19) symptoms when infected. Thus, chemical compositions, SARS-CoV-2′s spike protein, and angiotensin-converting enzyme 2 (ACE2) receptor interaction along with ACE2 activity inhibition, total phenolic content, and free radical scavenging capacities of dill water and ethanol extracts (WE/EE) were evaluated. As a result, 10 compounds were tentatively identified, with quercetin glucuronide having the highest peak intensity. Dill WE33.3 and EE3.3 (33.3 and 3.3 mg of dry dill equivalents/mL, respectively) showed 66% and 79% SARS-CoV-2′s spike protein and ACE2 receptor interaction inhibition, respectively. In ACE2 inhibition, 5.0 mg/mL WE and EE had 85 and 88% inhibition, respectively, whereas 0.5 mg/mL showed 33 and 11% inhibition, respectively. The Dill WE had a significantly greater total phenolic content (TPC), radical scavenging capacity (RDSC), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) values of 15.28 mg GAE/g, 595.21, 90.31, and 36.76 μmol TE/g, respectively, compared to the dill EE (2.63 mg GAE/g, 248.20, 10.38, and 0.85 μmol TE/g, respectively).

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A Review on the Potential Use of Medicinal Plants from the Apiaceae and the Rosaceae Families in Cardiovascular Diseases—Experimental Evidence and Traditional Applications

Celiński,

Krzemińska,

Grzywa-Celińska

et al. 2024

Applied Sciences

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Cardiovascular diseases are the leading cause of mortality worldwide. The World Health Organization has presented alarming data stating that in 2019, 17.9 million people globally died due to cardiovascular diseases, constituting 32% of all deaths. Despite increasingly advanced pharmacological and procedural treatment methods for these diseases, there is still a quest for new therapeutic possibilities that promise even greater efficacy and safety. The overriding purpose of this study is to provide an insight into the traditional uses of species from the Apiaceae and Rosaceae families as well as to systematize knowledge regarding their scientifically proven cardiovascular activities (animal studies and clinical trials). The review is intended to indicate knowledge gaps for future studies concerning plants used in traditional medicine but without scientific research. As a result, various plant species from both Apiaceae and Rosaceae family have been collected and described based on their study that has proven their effectiveness and uses in cardiovascular diseases. Most of these plants have a hypotensive effect, followed by anti-hyperlipidemic, vasorelaxant, antithrombotic, and diuretic activity. These are the mechanisms that contribute to various cardiovascular diseases, such as heart attack, coronary heart disease, hypertension, and stroke.

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Effects of Anethum graveolens (dill) and its derivatives on controlling cardiovascular risk factors: A systematic review and meta-analysis

Cited by 3 publications

References 38 publications

Dill

Dill

Chemical Compositions of Dill (Anethum graveolens L.) Water and Ethanol Extracts and Their Potential in Blocking the SARS-CoV-2 Entry into Cells and Free Radical Scavenging Capacities

A Review on the Potential Use of Medicinal Plants from the Apiaceae and the Rosaceae Families in Cardiovascular Diseases—Experimental Evidence and Traditional Applications

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