Effects of Androgens on Bone in Men and Women

McGriff-Lee, Nayahmka; Kalantaridou, Sophia Ν.; Pucino, Frank; Calis, Karim A.

doi:10.1385/bmm:3:1:051

Cited by 6 publications

(8 citation statements)

References 58 publications

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“…26,[27][28][29][30]31,[32][33][34][35][36][37][38][39] The therapeutic use of testosterone in women became widespread in the last decade. Exogenous testosterone therapy appears to improve libido, mood and well-being, and bone and muscle mass.…”

Section: Testosterone Therapymentioning

confidence: 99%

Androgen Treatment in Women

Kalantaridou

Calis

2007

Postgraduate Obstetrics & Gynecology

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Learning Objectives: After reading this issue, the participant should be able to: 1. Describe androgen physiology in women and the causes of female androgen insufficiency. 2. List potential therapeutic uses of exogenous testosterone therapy in women. 3. Describe possible risks associated with testosterone treatment in women. The continuing education activity in Postgraduate Obstetrics & Gynecology is intended for obstetricians, gynecologists, andother health care professionals with an interest in the diagnosis and treatment of obstetric and gynecological conditions.

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Section: Testosterone Therapymentioning

confidence: 99%

Androgen Treatment in Women

Kalantaridou

Calis

2007

Postgraduate Obstetrics & Gynecology

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“…Androgen receptors are found in all bone cells (osteoblasts, osteoclasts, and osteocytes), but are predominantly expressed in osteoblasts [38,39]. Androgens modulate the bone remodelling cycle by both direct androgenic activity and biotransformation to estrogens.…”

Section: Effect Of Testosterone Therapy On Bone and Muscle Massmentioning

confidence: 99%

Androgen treatment in women

Kalantaridou

Calis

2006

Current Opinion in Endocrinology and Diabetes

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Purpose of reviewTestosterone therapy for women, particularly those with natural or surgically induced menopause, albeit controversial, is becoming more widespread. This review presents current data regarding the effects of endogenous androgen and examines recent findings using testosterone therapy in women. Recent findingsCurrent evidence indicates that androgens have important biological effects in women, acting directly via androgen receptors in tissues, such as bone, skin fibroblasts, hair follicles and sebaceous glands. They also act indirectly via the aromatization of testosterone to estrogen on various sites, such as the ovaries, bone, brain, heart and adipose tissue. Data from randomized controlled trials suggest that exogenous testosterone therapy improves sexual function, mood, and bone mineral density in women with androgen insufficiency. Summary Androgen therapy may be necessary for the management of carefully selected women with androgen insufficiency. Women with natural or surgically induced menopause may be candidates for testosterone therapy if they have decreased sexual desire and no other identifiable cause for decreased libido. Data from studies investigating the effects of testosterone therapy in young women with androgen insufficiency are needed. Common adverse effects of testosterone therapy include hirsutism and acne, which reverse with discontinuation of treatment. Long-term trials evaluating safety and effectiveness of testosterone therapy in women are lacking.Sponsorship: Drs Kalantaridou and Calis are associate investigators on a National Institutes of Health (NIH) study of a transdermal testosterone patch in young women with premature ovarian failure, which is part of a cooperative research and development agreement (CRADA) between the NIH and Procter and Gamble.

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“…Estrogen exerts osteoprotective effects which play an important role in maintaining bone structure and density [10]. It exerts a direct effect on bone by binding to estrogen receptors (ERα and ERβ) located on bone cells [11]. This activation of estrogen-receptor complex will stimulate osteoblast differentiation while suppressing the activity of receptor activator of nuclear factor kappa-B ligand (RANKL), which is crucial for osteoclast formation and differentiation [12].…”

Section: Introductionmentioning

confidence: 99%

The effects of Labisia pumila on postmenopausal osteoporotic rat model: Dose and time-dependent micro-CT analysis

Effendy

Khamis

Soelaiman

et al. 2014

Journal of X-Ray Science and Technology

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BACKGROUND: Postmenopausal osteoporosis is best treated and prevented by estrogen replacement therapy (ERT). Although effective, ERT may cause breast cancer, uterine cancer and cardiovascular problems. Labisia pumila var. alata (LP), a herb with phytoestrogenic, antioxidative and anti-inflammatory effects has potential as an ERT alternative. OBJECTIVE: This study aimed to evaluate micro-CT analysis on the effects of LP supplementation on the trabecular microarchitecture of postmenopausal osteoporosis rat model. Micro-CT is an effective tool in detecting changes in trabecular bone structure and providing a three dimensional information which may replace other conventional bone analysis methods. METHODS: Ninety-six female Sprague-Dawley rats (4 to 5 months old) were randomly divided into six groups of baseline group (BL) Sham-operated (Sham), ovariectomised control (OVXC), ovariectomised with 64.5 μg/kg of Premarin (ERT), ovariectomised with 20 mg/kg of LP (LP20) and ovariectomised with 100 mg/kg of LP at (LP100). The vehicle (deionized water), Premarin and LP were given via daily oral gavages for three, six and nine weeks of treatment periods. Rats in BL group were euthanized before the start of the study, while other rats were euthanized after completion of their treatments. Femora were dissected out and trabecular bone microarchitecture analysed with micro-CT. RESULTS: Micro-CT analysis of OVXC rats revealed significant osteoporotic changes in connectivity density, trabecular bone volume, trabecular thickness, trabecular separation and trabecular number. Both ERT and LP were able to reverse all the OVX-induced bone changes with the best results seen with 100 mg/kg of LP for nine weeks duration of treatment. CONCLUSION: Micro-CT provides accurate and reliable information on trabecular bone parameters which aid in the diagnosis and treatment of osteoporosis. LP supplementation at 100 mg/kg was more effective than ERT in reversing ovariectomyinduced bone changes. Further studies are required to explore the potential of LP as ERT alternative in the treatment and prevention of postmenopausal osteoporosis.

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Effects of Androgens on Bone in Men and Women

Cited by 6 publications

References 58 publications

Androgen Treatment in Women

Androgen Treatment in Women

Androgen treatment in women

The effects of Labisia pumila on postmenopausal osteoporotic rat model: Dose and time-dependent micro-CT analysis

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