Effects of androgens and related steroids on liver functions and enzymes

Nishino, Y.

doi:10.1016/0306-039x(75)90004-5

Cited by 6 publications

(6 citation statements)

References 118 publications

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“…As regards to haematological and hepatic phenomena, clinical studies have shown an increase in erythropoiesis (Gurney, 1976;Palacios et al, 1983) because of the administration of anabolic steroids, whereas most hepatological studies suggest that changes in serum transaminase, total bilirubin and alkaline phosphatase values during the use of androgens are both minor and infrequent (see e.g. Nishino, 1975). Hepatic lesions (peliosis and tumours) are, however, reported in patients treated with synthetic anabolic steroids (Turani et al, 1983;Overly et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Androgenic steroid effects on liver and red cells.

Alén¹

1985

Br J Sports Med

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Haematological and hepatic effects of testosterone/anabolic steroid self-administration were investigated in five power athletes during 26 weeks of training. During steroid administration blood haematocrit had increased 9.6% (p less than .05) in the study group (n = 5), but not in the control group (n = 6). This erythropoietic phenomenon was supported by increased (p less than .05) RBC and unchanged MCV. Blood haemoglobin concentration did not change markedly and consequently MCHC level in the study group decreased significantly (p less than .001). Also the erythrocyte sedimentation rate decreased (p less than .05) in the study group. The mean values of serum alanine aminotransferase, alkaline phosphatase and gamma-glutamyltransferase were and remained within normal range in both groups, although those of the study group were higher. The mean values of serum aspartate aminotransferase exceeded the normal range (56 U/l, at highest) but this may be of muscular rather than hepatic origin because of the severe training. It can be concluded that erythropoiesis was stimulated and liver function mildly impaired due to sustained high-dose testosterone/anabolic steroid administration.

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Section: Introductionmentioning

confidence: 99%

Androgenic steroid effects on liver and red cells.

Alén¹

1985

Br J Sports Med

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“…It is possible that this was due to the fact that D H T is a physiologically active substance, and TP and M must first be metabolished. It has indeed been proposed that certain androgenic substances may cause inhibition of the metabolism of other drugs (Sotaniemi et al 1973;Nishino 1975).…”

Section: Discussionmentioning

confidence: 99%

“…Numerous reports indicate that steroid inactivation in the endoplasmic reticulum of hepatocytes is carried out b y the same enzyme system responsible for the oxidation of foreign compounds (Tuttenberg et al 1974). Interactions between steroids a n d d r u g metabolism have been extensively described (Sotaniemi et al 1973;Nishino 1975). T h e production of androgens and/or the treatment with androgens is apparently the dominant factor in determining sex variations in the enzymic metabolism of drugs in different species (Gillette 1967).…”

mentioning

confidence: 99%

Effect of Androgens on Antipyrine Metabolism in the Rabbit

et al. 1978

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The inactivation of endogenous steroids and foreign compounds by the liver hydroxylative pathway, can be modified by androgenic substances. The inhibitory or inductory activity, can be estimated by measuring the half‐life of antipyrine. Androgens (testosterone propionate, 5α‐dihydro‐testosterone and mesterolone) reduce antipyrine metabolism in male rabbits. In females, androgens are not inhibitors, but one of them, 5α‐dihydrotestosterone, shows an inductive effect on liver oxidative mechanisms.

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“…This information has prompted research of these drugs and their analogs being used as possible contraceptives for men (Heber & Swerdloff, 1980). Both sexes increase their risk of water retention, liver disfunction (Kintzen & Silny, 1960;McDonald & Speicher, 1978;Sherlock, 1968;Nishino, 1975), liver cancer (Guy, 1973;Henderson, Richmond, & Summerling, 1972), and abnormal skeletal muscle changes (Rogozkin, 1979;MacDougall, Sale, & Elder, 1982). These drugs are particularly harmful if taken by individuals who have not yet reached full maturity, as their use can lead to serious growth disturbances particularly in the areas of sexual and bone development (Daniel & Bennett, 1976).…”

Section: Effects Of Anabolic Steroidsmentioning

confidence: 98%