Effects of an OX2R agonist on migration and removal of tau from mouse brain
Michiko Terada,
Kayo Mitsukawa,
Masanori Nakakariya
et al.
Abstract:Pathological proteins including tau are produced in neurons and released into interstitial fluid (ISF) in a neural activity-dependent manner during wakefulness. Pathological proteins in ISF can be removed from the brain via the glymphatic pathway during nighttime. Thus, in individuals with Alzheimer’s disease (AD) that have dysregulated sleep/wake rhythm, application of orexin receptor 2 (OX2R) agonists during daytime could recover the efflux of pathological proteins to ISF and indirectly promote the glymphati… Show more
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