Effects of an intensive weight loss program on knee joint loading in obese adults with knee osteoarthritis

Aaboe, J.; Bliddal, Henning; Messier, Stephen P.; Alkjær, Tine; Henriksen, Marius

doi:10.1016/j.joca.2011.03.006

Cited by 142 publications

(122 citation statements)

References 37 publications

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“…In-vivo tibiofemoral joint contact forces are not directly measureable during dynamic tasks (unless by instrumented total knee replacement (Kim et al, 2009)), and therefore must be estimated mathematically. A few previous studies have investigated the effect of weight loss on tibiofemoral contact forces in obese subjects with knee OA (Aaboe et al, 2011;Messier et al, 2005;Messier et al, 2011). These studies have shown that weight loss can be effective in reducing compressive joint loading, and that for each unit of weight lost, the joint compressive force was reduced by multiple units (Messier et al, 2005).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Aaboe et al, 2011;Messier et al, 2005;Messier et al, 2011).Aaboe et al showed that when obese participants with knee OA reduced their BMI from a mean of 36.9 to a mean of 31.9, peak compressive tibiofemoral joint contact force was reduced by 7%, along with lower axial impulse and decreased peak values of the external kneeadduction moment (Aaboe et al, 2011). For each Newton of weight loss, compressive loading was reduced by 2.2 N. Similarly, Messier et al have demonstrated a direct relationship between reduced body weight and reduced compressive tibiofemoral joint contact forces, with each pound of weight loss corresponding to a reduction of approximately 4 pounds of joint load…”

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confidence: 99%

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Obesity is associated with higher absolute tibiofemoral contact and muscle forces during gait with and without knee osteoarthritis

Harding

Dunbar

Hubley‐Kozey

et al. 2016

Clinical Biomechanics

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Section: Accepted Manuscriptmentioning

confidence: 99%

mentioning

confidence: 99%

Obesity is associated with higher absolute tibiofemoral contact and muscle forces during gait with and without knee osteoarthritis

Harding

Dunbar

Hubley‐Kozey

et al. 2016

Clinical Biomechanics

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“…107 Weight loss has been well demonstrated in human and canine patients to help with the pain and morbidity associated with OA. [108][109][110][111][112] Weight loss of 6.10% or more in obese dogs can significantly decrease subjectively assessed lameness associated with OA. 110 Objective improvement was also seen with kinematic gait analysis with weight loss of 8.85% or more.…”

Section: Weight Managementmentioning

confidence: 99%

Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum

et al. 2016

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(ACADEMIC)The object of this study was to compare growth factor and cytokine profiles in canine autologous conditioned serum (ACS) to canine plasma. Blood collected from 16 medium to large breed dogs was used to produce ACS (Orthokine ® vet irap 10 syringes) and citrated plasma (control). Canine-specific ELISA assays were run per manufacturers' instructions for interleukin (IL)-10, IL-4, tumor necrosis factor (TNF)-α, insulin-like growth factor (IGF)-1, fibroblast growth factor (FGF)-2, transforming growth factor (TGF)-β1, IL-1β, and interleukin-1 receptor antagonist (IL-1ra). Serum, in addition to plasma and ACS, was collected from an additional 6 dogs for TNF-α, IL-1β, and IL-1ra analysis (total of 22 dogs). Data were analyzed for differences in cytokine concentrations between ACS, plasma, and serum using the Wilcoxon signed-rank test with significance set at P<.05.There was a large variability in growth factor and cytokine concentrations between individual dogs in both plasma and ACS. There were no significant differences in IL-10, TNF-α, IGF-1, FGF-2, and TGF-β1 concentrations between ACS, plasma, or serum. ACS concentrations of IL-1β (median, range; 46.3 pg/mL, 0-828.8) and IL-4 (0.0 pg/mL, 0-244.1) were significantly increased compared to plasma (36.6 pg/mL, 0-657.1 and 0.0 pg/mL, 0-0, respectively). IL-1ra concentrations in ACS (median, range; 3458.9 pg/mL, 1,243.1-12,089.0) were significantly higher than plasma (692.3 pg/mL, 422.5-1,475.6), as was the IL-1ra:IL-1β ratio (39.9 and 7.2, respectively).iii Cytokine and Growth Factor Profiles in Canine Autologous Conditioned SerumDominique Marie Sawyere ABSTRACT (PUBLIC)Osteoarthritis (OA) is a common cause of pain and suffering in dogs and is challenging to treat effectively Current treatment for OA merely mask the signs of pain and do not promote regeneration of the damaged cartilage or alter the course of the disease. Many treatments also cause harmful side effects. Autologous conditioned serum (ACS) is a biological therapy that controls inflammation within the joint by specifically blocking the inflammatory cytokine interleukin (IL)-1β. In humans and horses ACS relieves the pain from OA and promotes cartilage regeneration. The purpose of this study was to compare levels of pro-and anti-inflammatory cytokines in canine ACS to that of normal canine plasma with the hypothesis that levels of anti-inflammatory cytokines would be higher in ACS compared to controls and that levels of pro-inflammatory cytokines would remain unchanged. Paired blood samples were collected from 22 large breed healthy dogs and processed in either irap®10 syringes (ACS) or in anti-coagulant as a control. For the last 6 dogs an additional serum sample was collected. Growth factor and cytokine levels were determined using canine-specific ELISAs. One pro-inflammatory cytokine (IL-1β) and two anti-inflammatory cytokines (IL-1ra and IL-4) were significantly higher in the ACS compared to plasma and IL-1ra levels were also higher in serum compared with plasma samples. Other levels w...

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“…A systematic review and meta-analysis by Christensen et al (2007) found that weight reduction significantly improved disability in obese knee osteoarthritis patients, and also showed clinical efficacy on pain reduction. More recently, Aaboe et al (2011) showed that for every 1 kg of weight loss, the peak knee load was diminished by 2.2 kg at a given walking speed, providing evidence to suggest that weight loss could be therapeutic for osteoarthritis patients in terms of reducing mechanical stress on the knee. A recent study by Richette et al (2011) examined obese knee osteoarthritis patients who underwent gastric surgery to drastically lose weight.…”

Section: Effect Of Weight Lossmentioning

confidence: 99%

Obesity and knee osteoarthritis

2012

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Recent prospective studies demonstrate obesity as a primary risk factor for incident knee osteoarthritis. The potential mechanisms to link obesity and knee osteoarthritis, as both a biomechanical and metabolic condition are strongly linked. It has been established that weight loss for obese patients with knee osteoarthritis is clinically beneficial, for pain reduction, and for improved function. The exact mechanism linking obesity and osteoarthritis is complex; however, it is our opinion that further evidence supporting the link between the two diseases will be useful in providing clinicians and researchers with targets for physical therapy and pharmacological management of obese patients with knee osteoarthritis.

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Effects of an intensive weight loss program on knee joint loading in obese adults with knee osteoarthritis

Abstract: Weight loss is an excellent short-term investment in terms of joint loading for patients with combined obesity and knee OA. The effects of sustained weight loss on disease progression and symptoms in relation to biomechanical factors remain to be shown.

Cited by 142 publications

References 37 publications

Obesity is associated with higher absolute tibiofemoral contact and muscle forces during gait with and without knee osteoarthritis

Obesity is associated with higher absolute tibiofemoral contact and muscle forces during gait with and without knee osteoarthritis

Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum

Obesity and knee osteoarthritis

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