Effects of an individualized exercise training program on severity markers of obstructive sleep apnea syndrome: a randomised controlled trial

Bughin, François; Desplan, M.; Mestejanot, C.; Picot, Marie‐Christine; Roubille, François; Jaffuel, Dany; Mercier, Jacques; Jaussent, Isabelle; Dauvilliers, Yves

doi:10.1016/j.sleep.2020.02.008

Cited by 18 publications

(21 citation statements)

References 40 publications

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“…In line with previous studies 46 , 47 , ET also caused an improvement in the severity of OSA. The observation that exercise changed arousals and AHI demonstrates that ET improves sleep pattern in patients with OSA.…”

Section: Discussionsupporting

confidence: 93%

Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea

Ueno-Pardi

Duran

Matheus

et al. 2022

Sci Rep

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Impaired glucose metabolism reflects neuronal/synaptic dysfunction and cognitive function decline in patients with obstructive sleep apnea (OSA). The study investigated the extent to which exercise training (ET) improves cerebral metabolic glucose rate (CMRgl) and cognitive function in patients with OSA. Patients with moderate to severe OSA were randomly assigned to ET (3 times/week, n = 23) or no intervention (control, n = 24). Echocardiography and apolipoprotein ε4 (APOEε4) genotyping were obtained at baseline. Both groups underwent cardiopulmonary exercise testing, polysomnography, cognitive tests, brain magnetic resonance imaging, and 18F-fluoro-2-deoxy-d-Glucose positron emission tomography (18FDG-PET) at baseline and study end. Compared with control, exercise-trained group had improved exercise capacity, decreased apnea–hypopnea index (AHI), oxygen desaturation and arousal index; increased attention/executive functioning, increased CMRgl in the right frontal lobe (P < 0.05). After ET an inverse relationships occurred between CMRgl and obstructive AHI (r = − 0.43, P < 0.05) and apnea arousal index (r = − 0.53, P < 0.05), and between the changes in CMRgl and changes in mean O2 saturation during sleep and non-rapid eye movement sleep (r = − 0.43, P < 0.05), desaturation during arousal (r = − 0.44, P < 0.05), and time to attention function testing (r = − 0.46, P < 0.05). ET improves OSA severity and CMRg in the frontal lobe, which helps explain the improvement in attention/executive functioning. Our study provides promising data that reinforce the growing idea that ET may be a valuable tool to prevent hypoxia associated with decreased brain metabolism and cognitive functioning in patients with moderate to severe OSA.Trial registration: NCT02289625 (13/11/2014).

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Section: Discussionsupporting

confidence: 93%

Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea

Ueno-Pardi

Duran

Matheus

et al. 2022

Sci Rep

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“…The main findings revealed that 6 weeks of this combination program was able to ameliorate EDS, lower the risk of SRBDs, improve most of the anthropometric variables, and increase physical fitness in adults with obesity and SRBDs. These results are similar to previous studies which showed an improvement in sleep quality 7 , 10 , 11 , 12 , 25 , 26 , 27 , and sleep indices 12 , 25 , 28 after completion of exercise programs. However, the study period for those studies was longer than the present study, excepted for the study of Ebrahimi et al (2017) 27 which examined the effect of yoga and aerobic exercise at week 6 and week 12.…”

Section: Discussionsupporting

confidence: 92%

“…In addition, the exercise prescription of those previous studies was performed differently to our study. For example, some studies used individual aerobic exercises (AE) 7 , AE plus RT 12 , diet and AE combined with RT 10 , home-based combination program for the aging 11 , and lifestyle modification including diet and physical activity 7 , 29 . There were limited studies using a HIIT program for SRBDs patients 19 , 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Conservative intervention has been established as an alternative treatment for SRBDs, such as behavioral modification, including exercise and/or combined with diet control 7 , 8 , 9 , 10 , 11 , 12 , 13 . It was found that these interventions were beneficial effects on sleep parameters 7 , 8 , 9 , 10 , 11 , 12 , 13 . Previously, a number of studies found that EDS 7 , 9 , 11 , snoring 10 , and sleep indices 9 , 12 , 13 were improved after exercise intervention.…”

Section: Introductionmentioning

confidence: 99%

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Effects of six weeks high-intensity interval training and resistance training in adults with obesity and sleep related breathing disorders

Longlalerng¹,

Nakeaw²,

Charawae³

et al. 2021

Sleep Sci

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Introduction:The effects of high-intensity interval training (HIIT) combined with resistance training (RT) in adults with obesity and sleep-related breathing disorders (SRBDs) is limited.Objective: This study aimed to examine the effects of HIIT combined with RT on subjective sleep disorders in adults with obesity and SRBDs. Material and Methods: This study was a pre-and post-test design. Seventeen adults with obesity and SRBDs were recruited into the study. They received 24 minutes of HIIT and 30 minutes of RT, 3 times/week for 6 weeks. The Epworth sleepiness scale (daytime sleepiness), Berlin questionnaire (snoring and daytime sleepiness category), estimated maximum oxygen consumption (VO 2 max), muscle strength using 1-repetition maximum, anthropometric variables, and blood biomarkers were examined at baseline and after 6 weeks of training. Results: The Epworth sleepiness scale, Berlin questionnaire (daytime sleepiness category), and the number of risks associated with sleep apnea using the Berlin questionnaire were significantly decreased after 6 weeks of training (all p<0.01). The estimated VO 2 max and muscle strength were significantly increased at Week 6 (all p<0.05). Body weight, body mass index, % body fat, and hip circumference were significantly decreased at Week 6 (all p<0.05). No significant changes were observed in blood biomarkers, except for fasting blood glucose (p<0.01). Conclusion: Six weeks of HIIT combined with RT has beneficial effects on subjective sleep disorders, estimated VO 2 max, muscle strength, and most anthropometric variables in adults with obesity and SRBDs.

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“… 10 , 11 For example, PA has positive effects on AHI in terms of rapid eye movement (REM) and non-REM sleep, subjective sleepiness, cardiometabolic risk factors associated with OSA, and VO2peak, which is associated with a significant survival benefit. 11 – 14 However, individuals with OSA report low levels of PA and have low aerobic capacity. 11 Their symptoms may hamper daily life activities in several ways, and PA appears to decrease with increasing AHI.…”

Section: Introductionmentioning

confidence: 99%

An individualized mobile health intervention to promote physical activity in adults with obstructive sleep apnea: An intervention mapping approach

Latrille

Chapel

Héraud³

et al. 2023

DIGITAL HEALTH

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Objective Combining continuous positive airway pressure with physical activity (PA) might be a promising strategy to treat obstructive sleep apnea (OSA). This article describes how intervention mapping (IM) can guide the development, content, and mechanisms of action of a mobile application to promote PA in adults with OSA. Methods To develop the program, the IM approach was followed. This article presents the first three steps of IM to develop a mixed intervention (with interventionists and a digital application) aiming to: (1) assess patients’ health problems and needs in a literature review to determine their expectations and perceived facilitators and barriers to PA behavior change and thus select the determinants of behavior; (2) formulate the expected intervention outcomes and objectives to be met to achieve the overall program goals; and (3) select and implement the behavior change techniques (BCTs) to achieve the change objectives. Results The literature review identified the relevant determinants (e.g., self-efficacy, coping, planning, and habit) of PA behavior using the health action process approach and multiprocess action control. These results were used to specify the program outcomes for PA adapted to physical, psychological, and social parameters. Overall, 11 performance objectives and 30 change objectives were defined. Lastly, BCTs and practical applications were identified. Conclusions The study provides a theoretical and methodological basis for researchers and practitioners given the current paucity of evidence-based PA interventions for adults with OSA. It addresses the lack of BCTs (framing and prompts/cue techniques) and meaningful behavioral determinants (identity and habit) in most interventions.

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Effects of an individualized exercise training program on severity markers of obstructive sleep apnea syndrome: a randomised controlled trial

Abstract: HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

Cited by 18 publications

References 40 publications

Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea

Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea

Effects of six weeks high-intensity interval training and resistance training in adults with obesity and sleep related breathing disorders

An individualized mobile health intervention to promote physical activity in adults with obstructive sleep apnea: An intervention mapping approach

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