Effects of an anabolic steroid on reproduction in female rats

Howe, G. R.; Morello, Carol

doi:10.1016/0039-128x(85)90015-7

Cited by 6 publications

(4 citation statements)

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“…Similar results have been reported in horses (Maher et al. 1983), in female rats (Howe & Morello 1985) and in veal calves (Cannizzo et al. 2007).…”

Section: Discussionsupporting

confidence: 89%

“…Our study revealed that treatment with BOL had no significant effect on the final bwt and the bwt gain of the treated groups compared with the control group. Similar results have been reported in horses (Maher et al 1983), in female rats (Howe & Morello 1985) and in veal calves (Cannizzo et al 2007). The index weight of testes and epididymes was decreased significantly in the BOL-treated groups, particularly in group C compared with the control group.…”

Section: Discussionsupporting

confidence: 88%

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Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits

Oda¹,

El-Ashmawy

2012

Int J Experimental Path

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This study was conducted to evaluate the adverse effects of the anabolic steroid, boldenone undecylenate (BOL) on reproductive functions of male rabbits. Thirty white New Zealand mature male rabbits were divided into three groups (10 rabbits each). Group A rabbits served as a control group. Group B rabbits received 4.4 mg/kg body weight (bwt) BOL 5% oily solution. Group C rabbits received 8.8 mg/kg bwt BOL. Rabbits were injected intramuscularly twice weekly for two months. BOL had no significant effect on the bwt and bwt gain. Testes and epididymis weights were decreased significantly in the BOL-treated groups. BOL caused significant reduction in serum testosterone level, seminal volume, sperm motility, and sperm count. No abnormalities were detected in the sperm morphology of the BOL-treated groups. Histopathological alterations in the testes and epididymis were marked in the group C rabbits. These results indicate that administration of BOL exerts a significant harmful effect on the reproductive functions of male rabbits.

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“…Similar results have been reported in horses (Maher et al. 1983), in female rats (Howe & Morello 1985) and in veal calves (Cannizzo et al. 2007).…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits

Oda¹,

El-Ashmawy

2012

Int J Experimental Path

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“…The side effects of anabolic steroids on the physiology and function of the reproductive system have been proved [3]. The side effects of steroids on the histology of testis [4], prostate [5], ovary, and uterus [6][7], spermatogenesis [8], genitalia malformation, and ovarian cyclical activity [1,[9][10][11] have also been shown. Ovarian and uterine histology and follicular score have been investigated after the ND treatment [6,7]; however, quantitative aspects of the ovary and oocytes have received little attention.…”

Section: Introductionmentioning

confidence: 99%

Stereological estimation of ovarian oocyte volume, surface area and number: application on mice treated with nandrolone decanoate

Karbalay‐Doust

Noorafshan

2012

Folia Histochem Cytobiol.

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Changes in the number and size of oocytes can lead to fertilization problems. The present study aimed to evaluate the number, volume, and surface area of oocytes in healthy as well as nandrolone decanoate-treated (ND) mice using stereological methods. Five control mice received vehicle, and five ND-treated mice received ND. Using the 'isotropic Cavalieri' design', the ovary was sectioned. The volume of the ovary (cortex and medulla) was estimated. The oocytes' volume and surface area were estimated using the invariator. The number of the oocytes was estimated using an optical disector. The volumes of the ovary, cortex, and medulla decreased ~50% in the ND-treated mice. The mean number (coefficient of variation) of preantral, antral, and atretic oocytes in the control ovary were 1,690 (0.29), 2,100 (0.52), and 3,900 (0.2), respectively, which decreased ~54%, ~87%, and ~91%, respectively in the ND-treated animals. The mean volume (coefficient of variation) of the preantral, antral, and atretic oocytes were 86,000 (0.27), 110,000 (0.48), and 27,000 (0.33) mm 3 , respectively. The mean surface area (coefficient of variation) of the three types of oocytes were 9,000 (0.24), 9,900 (0.28), and 4,700 (0.21) mm 2 , respectively. These parameters remained unchanged in the ND-treated mice. ND induces reduction in the number of oocytes, but not in the volume or the surface area.

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“…Anabolic androgenic steroids (AAS) can be useful adjuvant therapy for refractory anemia, hereditary angioedema, breast cancer, and starvation status (Clark et al,1997), as well as for the treatment of hypogonadism, as they stimulate sexual development (Wilson and Griffin,1980). AAS, including testosterone and its synthetic analogues have also been used by healthy adolescents and adults, athletes and nonathletes to increase muscle mass, strength and physical dexterity (Iriart and Andrade,2002). It is estimated that there are over 45 anabolic steroid compounds available for abusive consumption by athletes, and in the past few years, their use has increased among male and female subjects (Lane and Connor,1994; Bishop,2005; Biden,2006).…”

mentioning

confidence: 99%

Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus

Chuffa¹,

Souza²,

Frei³

et al. 2010

The Anatomical Record

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In the past decades, the therapeutic use of anabolic androgenic steroids (AAS) has been overshadowed by illicit abuse of these drugs by athletes and non-athletes. Since that AAS can affect the reproductive tract, resulting in reproduction and fertilization damages, the purpose of this study was to investigate the nandrolone decanoate (ND) effects, associated or not with physical effort, on the uterine histomorphometric parameters. Female Wistar rats, sedentary or not, were exposed to treatment with ND by intraperitoneal injection (5 mg/kg/day, once a week) during four consecutive weeks. Control animals, sedentary or not, received vehicle alone (propylene glycol) in the same manner. The physical activity was forced swimming (20 min/ day). During the experiment, all animals were monitored by daily vaginal smears. After 30 days of treatment, the females were sacrificed and their uteri collected and examined under light microscopy techniques. The NDtreated females showed estrus acyclicity and decreased thickness of both the epithelium and endometrial stroma. A reduction in the number and size of blood vessels was also found in ND-treated rats submitted to physical effort when compared to ND sedentary rats. ND-treated rats, regardless of exercise, exhibited stromal fibrosis and reduced gland ducts that displayed high mitotic activity. A remarkable widespread presence of leukocytes occurred in rats receiving ND and submitted to exercise. These results suggest that ND associated or not with physical effort causes histomorphometric changes to the rat uterus. Anat Rec, 294:335-341, 2011. V V C 2010 Wiley-Liss, Inc.

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Effects of an anabolic steroid on reproduction in female rats

Cited by 6 publications

References 5 publications

Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits

Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits

Stereological estimation of ovarian oocyte volume, surface area and number: application on mice treated with nandrolone decanoate

Nandrolone Decanoate and Physical Effort: Histological and Morphometrical Assessment in Adult Rat Uterus

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