Effects of an acute strawberry (Fragaria × ananassa) consumption on the plasma antioxidant status of healthy subjects

Romandini, Stefania; Mazzoni, Luca; Giampieri, Francesca; Tulipani, Sara; Gasparrini, Massimiliano; Forbes-Hernández, Tamara Y.; Locorotondo, Nicola; D’Alessandro, Maria Michela; Mezzetti, Bruno; Bompadre, Stefano; Álvarez-Suarez, José M.

doi:10.3233/jbr-130055

Cited by 31 publications

(19 citation statements)

References 43 publications

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“…The choice of using “Alba” strawberries in this study was also based on the very interesting results obtained in recent years using this cultivar, both in vitro 37 38 and in vivo 39 40 .…”

Section: Discussionmentioning

confidence: 99%

Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells

Amatori

Mazzoni

Álvarez-Suarez

et al. 2016

Sci Rep

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We describe the biological effects of a polyphenol-rich strawberry extract (PRSE), obtained from the “Alba” variety, on the highly aggressive and invasive basal-like breast cancer cell line A17. Dose-response and time-course experiments showed that PRSE is able to decrease the cellular viability of A17 cells in a time- and dose-dependent manner. PRSE effect on cell survival was investigated in other tumor and normal cell lines of both mouse and human origin, demonstrating that PRSE is more active against breast cancer cells. Cytofluorimetric analysis of A17 cells demonstrated that sub-lethal doses of PRSE reduce the number of cells in S phase, inducing the accumulation of cells in G1 phase of cell cycle. In addition, the migration of A17 cells was studied monitoring the ability of PRSE to inhibit cellular mobility. Gene expression analysis revealed the modulation of 12 genes playing different roles in the cellular migration, adhesion and invasion processes. Finally, in vivo experiments showed the growth inhibition of A17 cells orthotopically transplanted into FVB syngeneic mice fed with PRSE. Overall, we demonstrated that PRSE exerts important biological activities against a highly invasive breast cancer cell line both in vitro and in vivo suggesting the strawberry extracts as preventive/curative food strategy.

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Section: Discussionmentioning

confidence: 99%

Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells

Amatori

Mazzoni

Álvarez-Suarez

et al. 2016

Sci Rep

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“…They are also rich in phenolic compounds, including anthocyanins, hydrolyzable tannins, and phenolic acids (Giampieri et al, 2012). Vitamin C and phenolic compounds are efficient antioxidants, and the potential role of strawberry consumption in human health and disease prevention is an active research area (Romandini et al, 2013). Tempering the enthusiasm for strawberry consumption is their prominent position on the list of foods with the highest pesticide residues (Environmental Working Group, 2013).…”

Section: Fragaria Species and Their Ploidy Level Mating System And Gmentioning

confidence: 99%

Fragaria: A genus with deep historical roots and ripe for evolutionary and ecological insights

Liston

Cronn

Ashman

2014

American J of Botany

150

138

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The cultivated strawberry, Fragaria ×ananassa, is one of the youngest domesticated plants. Its 18th century origin via hybridization in Europe between the North American F. virginiana and the South American F. chiloensis was documented by the botanist Antoine Nicolas Duchesne. His 1766 "Natural History of Strawberries" is an extraordinary work that integrates fundamental discoveries on the biology, ecology, and phylogeny of Fragaria with applied information on cultivation and ethnobotanical uses, serving as an inspiration for current research in the genus. Fragaria species exhibit the full range of sexual systems in the gynodioecy pathway from hermaphroditism to dioecy (and back again), as well as variation in self-compatibility, and evidence of sex chromosomes with female heterogamety. The genus is also characterized by interspecific hybridization and polyploidy, with a natural range of ploidy levels from diploids to decaploids. This biological diversity, combined with the availability of genomic resources and the ease of growing and experimenting with the plants, makes Fragaria a very attractive system for ecological and evolutionary genomics. The goal of this review is to introduce Fragaria as a model genus and to provide a roadmap for future integrative research. These research directions will deepen our understanding of the ecological and evolutionary context that shaped the ancestors of the cultivated strawberry, not only providing information that can be applied to efforts to shape the future of this important fruit crop but also our understanding of key transitions in plant evolution.

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“…Fruit and vegetables protect human from several chronic diseases, where they contain many antioxidants and bioactive compounds (Romandini et al . ). Strawberry ( Fragaria × ananassa ) is a widely grown hybrid species of the genus Fragaria.…”

mentioning

confidence: 97%

Effect of strawberry (Fragaria × ananassa) leaf extract on diabetic nephropathy in rats

Ibrahim

El-Maksoud

2015

Int J Experimental Path

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Diabetic nephropathy is a clinical syndrome characterized by albuminuria, hypertension and progressive renal insufficiency. The aim of this study was to investigate the effect of strawberry (Fragaria × ananassa) leaf extract on diabetic nephropathy in rats. Streptozotocin (STZ) diabetic rats were orally treated with three doses (50, 100 and 200 mg/kg) of strawberry leaf extract for 30 days. Nephropathy biomarkers in plasma and kidney were examined at the end of the experiment. The three doses of strawberry leaf extract significantly decreased the levels of blood glucose, urea nitrogen, plasma creatinine, kidney injury molecule (Kim)-1, renal malondialdehyde (MDA), tumour necrosis factor alpha (TNF-α), interleukin (IL)- 6 and caspase-3 in diabetic rats. Meanwhile, the levels of plasma insulin, albumin, uric acid, renal catalase (CAT), superoxide dismutase (SOD) and vascular endothelial growth factor A (VEGF-A) were significantly elevated in diabetic rats treated with strawberry leaf extract. These results indicate the role of strawberry leaves extract as anti-diabetic, antioxidant, anti-inflammatory and anti-apoptosis in diabetic nephropathy.

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Effects of an acute strawberry (Fragaria × ananassa) consumption on the plasma antioxidant status of healthy subjects

Cited by 31 publications

References 43 publications

Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells

Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells

Fragaria: A genus with deep historical roots and ripe for evolutionary and ecological insights

Effect of strawberry (Fragaria × ananassa) leaf extract on diabetic nephropathy in rats

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