Effects of an ACTH 4-9 related peptide upon intracranial self stimulation and general activity in the rat

Katz, Richard J.

doi:10.1007/bf00433254

Cited by 15 publications

(2 citation statements)

References 13 publications

(12 reference statements)

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“…NAc, (21)]. This is supported by findings that ACTH and corticosterone, which are triggered by CRF, can facilitate brain stimulation reward (87, 88) and are required for acquisition and maintenance of cocaine self-administration (89). …”

Section: Discussionmentioning

confidence: 73%

Sex Differences in Sensitivity to the Depressive-like Effects of the Kappa Opioid Receptor Agonist U-50488 in Rats

Russell

Rachlin

Smith

et al. 2014

Biological Psychiatry

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Background Dynorphin, an endogenous ligand at kappa opioid receptors (KOR), produces depressive-like effects and contributes to addictive behavior in male non-human primates and rodents. Although comorbidity of depression and addiction is greater in women than men, the role of KORs in female motivated behavior is unknown. Methods In adult Sprague Dawley rats, we used intracranial self-stimulation (ICSS) to measure effects of the KOR agonist (±)-trans-U-50488 methanesulfonate salt (U-50488) (0.0 – 10.0 mg/kg) on brain stimulation reward in gonadally intact and castrated males and in females at estrous cycle stages associated with low and high estrogen levels. Pharmacokinetic studies of U-50488 in plasma and brain were conducted. Immunohistochemistry was used to identify sex-dependent expression of U-50488-induced c-Fos in brain. Results U-50488 dose-dependently increased the frequency of stimulation (threshold) required to maintain ICSS responding in male and female rats, a depressive-like effect. However, females were significantly less sensitive than males to the threshold-increasing effects of U-50488, independent of estrous cycle stage in females or gonadectomy in males. Although initial plasma concentrations of U-50488 were higher in females, there were no sex differences in brain concentrations. Sex differences in U-50488-induced c-Fos activation were observed in CRF-containing neurons of the paraventricular nucleus (PVN) of the hypothalamus and primarily in non-CRF-containing neurons of the bed nucleus of the stria terminalis (BNST). Conclusions These data suggest that the role of KORs in motivated behavior of rats is sexdependent, which has important ramifications for the study and treatment of mood-related disorders including depression and drug addiction in people.

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Section: Discussionmentioning

confidence: 73%

Sex Differences in Sensitivity to the Depressive-like Effects of the Kappa Opioid Receptor Agonist U-50488 in Rats

Russell

Rachlin

Smith

et al. 2014

Biological Psychiatry

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“…There are data in the literature regarding the direct influence of ACTH-like peptides on the mechanisms of the "reward system": the rats rapidly learned to self-inject ACTH 1-24 or ACTH 4-10 [7]; the subcutaneous injections of ACTH 4-10 increased the frequency of self-stimulation in rats that is induced by stimulation of the medial septum, while the analog of ACTH 4-9, Org 2766, intensified self-stimulation when the medial forebrain bundle was stimulated. However, these effects, as compared with those we observed, are brief in character.…”

Section: Resultsmentioning

confidence: 99%

Influence of new ACTH fragments on self-stimulation, avoidance, and grooming behavior in rabbits

Burchuladze

Chabak

Chippens

1994

Neurosci Behav Physiol

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The effects of new cyclic analogs of ACTH fragments, EHFRWGKPVG-NH2 and KHFRWG-NH2, which have specific and nonspecific active centers in their structure, in the self-stimulation, avoidance, and grooming behavior of rabbits were investigated in this study. The intraventricular administration of EHFRWGKPVG-NH2 in doses of 0.1-2.5 micrograms increased the frequency of self-stimulation (SS), while in doses of 4-5 micrograms, it decreased the frequency of self-stimulation. The administration of KHFRWG-NH2 in doses of 0.1-5.o micrograms, induced a decrease in the frequency of SS by 25-30% in the first 15 min following the injections; this indicator returned to the baseline level thereafter, and decreased again. SS was more intense after 24-48 h, 5-8% higher than the baseline level, and remained practically unchanged over the course of a two-hour experiment. The administration of the EHFRWGKPVG-NH2 fragment in doses of 0.5-2.0 micrograms increased the latent period of the avoidance reaction, decreased the time of the anxiety state, and increased the time of the comfort state. In addition to these changes, both ACTH fragments induced intense grooming, increased the duration of grooming by 200-400% as compared with the control animals which were administered physiological solution.

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Small peptides and nerve growth: Therapeutic implications

Taylor¹,

Moreau²,

DeFeudis³

1987

Drug Development Research

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Factors Associated with Growth Hormone Thyrotropin-Releasing Hormone (TRH) Endogenous Opioids Substance-P OTHER SMALL PEPTIDES AND NERVE REGENERATION CONCLUDING REMARKS: DIRECTION FOR FUTURE RESEARCH REFERENCES ABSTRACT Taylor, J.E., J.P. Moreau, and F.V. DeFeudis: Small peptides and nerve growth: Therapeutic implications. Drug Dev. Res. 11 :75-86, 1987.Studies of the effects of small peptides (< 10,000 Da), i.e., fragments of naturally occurring hormones (e.g., adrenocorticotrophic hormones [ACTH]: a-melanocyte-stimulating hor- 76Taylor, Moreau, and DeFeudis mone [a-MSH]), hypophysiotrophic factors (e.g., growth hormone-releasing hormone [GH-RH], thyrotropin-releasing hormone [TRH]), other growth factors, and synthetic compounds on peripheral and CNS neuronal regeneration and behavior have been reviewed and analyzed. It seems apparent that certain hormonal fragments, growth factors, and some synthetic compounds (e.g., the ACTHla-MSH analogue Org 2766) can enhance peripheral, and possibly CNS, nerve regeneration. Further study of newer peptide-analogues with increased potency, longer duration of activity, and greater selectivity of action might lead to the development of therapies for certain types of nerve injury and for neurodegenerative disorders.

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Effects of an ACTH 4-9 related peptide upon intracranial self stimulation and general activity in the rat

Cited by 15 publications

References 13 publications

Sex Differences in Sensitivity to the Depressive-like Effects of the Kappa Opioid Receptor Agonist U-50488 in Rats

Sex Differences in Sensitivity to the Depressive-like Effects of the Kappa Opioid Receptor Agonist U-50488 in Rats

Influence of new ACTH fragments on self-stimulation, avoidance, and grooming behavior in rabbits

Small peptides and nerve growth: Therapeutic implications

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