Effects of amphetamine on the plus-maze discriminative avoidance task in mice

Silva, Regina H.; Kameda, Sonia R.; Carvalho, Reinaldo de Amorim; Rigo, G. S.; Costa, K. L. B.; Taricano, I. D.; Frussa‐Filho, Roberto

doi:10.1007/s00213-001-0948-3

Cited by 39 publications

(4 citation statements)

References 53 publications

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“…Although the magnitude of the "startle response" on light to dark transition is commonly used as a measure of anxiety-like behavior (38) where a reduction in distance traveled is taken as indicative of a reduced anxietylike response, differences in baseline locomotion preclude this interpretation here. A reduced rate of change in locomotion following forced light transition is consistent with reduced rates of recovery that have been interpreted as increased anxiety-like behavior (46), and would be consistent with mammalian studies (106,107), but again, differences in basal locomotion makes it difficult to draw conclusions here.…”

Section: Drug Exposure Led To Changes In Behavior Consistent With Responses In Mammalian Systemssupporting

confidence: 62%

Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish

et al. 2022

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Developmental consequences of prenatal drug exposure have been reported in many human cohorts and animal studies. The long-lasting impact on the offspring—including motor and cognitive impairments, cranial and cardiac anomalies and increased prevalence of ADHD—is a socioeconomic burden worldwide. Identifying the molecular changes leading to developmental consequences could help ameliorate the deficits and limit the impact. In this study, we have used zebrafish, a well-established behavioral and genetic model with conserved drug response and reward pathways, to identify changes in behavior and cellular pathways in response to developmental exposure to amphetamine, nicotine or oxycodone. In the presence of the drug, exposed animals showed altered behavior, consistent with effects seen in mammalian systems, including impaired locomotion and altered habituation to acoustic startle. Differences in responses seen following acute and chronic exposure suggest adaptation to the presence of the drug. Transcriptomic analysis of exposed larvae revealed differential expression of numerous genes and alterations in many pathways, including those related to cell death, immunity and circadian rhythm regulation. Differential expression of circadian rhythm genes did not correlate with behavioral changes in the larvae, however, two of the circadian genes, arntl2 and per2, were also differentially expressed at later stages of development, suggesting a long-lasting impact of developmental exposures on circadian gene expression. The immediate-early genes, egr1, egr4, fosab, and junbb, which are associated with synaptic plasticity, were downregulated by all three drugs and in situ hybridization showed that the expression for all four genes was reduced across all neuroanatomical regions, including brain regions implicated in reward processing, addiction and other psychiatric conditions. We anticipate that these early changes in gene expression in response to drug exposure are likely to contribute to the consequences of prenatal exposure and their discovery might pave the way to therapeutic intervention to ameliorate the long-lasting deficits.

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Section: Drug Exposure Led To Changes In Behavior Consistent With Responses In Mammalian Systemssupporting

confidence: 62%

Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish

et al. 2022

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“…Both methamphetamine and amphetamine produce a broad spectrum of pharmacological and behavioral effects that depend largely on the dose and pattern of administration [4]. Although acute effects of methamphetamine or amphetamine on various memory performances are still controversial [5,6,7], long-term methamphetamine or amphetamine use is consistently reported to be associated with impaired performance on a number of cognitive tasks [3]. Several lines of evidence showed that high doses or binge administration of methamphetamine increased oxidative stress, nitrotyrosine protein modification, lipid peroxidation, dopamine depletion and neuronal damage, while these effects can be attenuated by antioxidants such as deferoxamine, α-tocopherol and baicalein [8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Preventive Effect of Baicalein on Methamphetamine-Induced Amnesia in the Passive Avoidance Test in Mice

et al. 2014

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Background/Aims: Methamphetamine abuse may produce cognitive impairment. Baicalein, a bioactive flavonoid, has antioxidative, anti-inflammatory and neuroprotective effects. This study examined the effects of baicalein pretreatment on memory performance in the passive avoidance test after either one dose or an acute binge of methamphetamine in Institute of Cancer Research (ICR) mice. Methods: Methamphetamine was administered by intraperitoneal (i.p.) injection of either one dose (3 mg/kg) or an acute binge (3 mg/kg, 4 i.p. injections at 2-hour intervals). The effects of baicalein pretreatment (1 mg/kg, i.p.) on methamphetamine-induced changes of locomotor activity and memory performance were compared with those of eticlopride, a selective dopamine D₂ receptor antagonist. The effects of baicalein on acute binge methamphetamine-induced oxidative stress (malondialdehyde- and nitrotyrosine-modified protein production) in the mouse hippocampus were also examined. Results: One-dose methamphetamine treatment (i.p., 30 min before or immediately after the training trial) induced hyperlocomotion and amnesia in mice, which were blocked by eticlopride but not by baicalein pretreatment. The memory performance in mice was impaired 5 days after acute binge methamphetamine, which was significantly attenuated by baicalein but not by eticlopride pretreatment. Baicalein pretreatment also attenuated acute binge methamphetamine-induced oxidative stress in the mouse hippocampus. Conclusions: Baicalein exhibits antioxidative and neuroprotective effects in attenuating acute binge methamphetamine-induced memory deficits and oxidative hippocampal damage.

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“…Craving has long been identified as an important contributor to behavioral loss of control and is considered a key area of treatment focus for addictive behaviors [4]. Research evidence has demonstrated that the experience of craving is qualitatively similar across a range of targets, including alcohol, food, soft drinks and tobacco [5–7].…”

Section: Introductionmentioning

confidence: 99%

“…Craving has also been shown to be a major risk factor in triggering relapse [8] and in predicting generally worse outcomes in treatment for substance abuse [9, 10]. Tackling craving is highly clinically relevant-treatment approaches that focus on the regulation of urges have proven to be effective in reducing rates of relapse in various behavioral domains [4, 11].…”

Section: Introductionmentioning

confidence: 99%

The effects of food craving and desire thinking on states of motivational challenge and threat and their physiological indices

et al. 2018

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Purpose Food craving has been shown to induce states of psychological challenge, indexed by increases in adrenaline but not cortisol production. The study aimed to test the relationship between challenge and (1) desire thinking (the active processing of the pleasant consequences of achieving a desired target and planning how to do so) and (2) craving. Methods Participants (N = 61) self-reported their levels of craving and desire thinking. They were then presented with situations in which their craving would be fulfilled or not via a false feedback practice task (a wordsearch task). During this period psycho-physiological measures of challenge and threat were taken. Results Higher levels of craving were linked to challenge only when the craved object was likely to be obtained. Whilst anticipating reward fulfillment, higher levels of craving were linked to higher levels of desire thinking. In turn, higher levels of desire thinking were related to lower levels of challenge. In contrast, during the processes of reward fulfillment, desire thinking was linked to increased challenge (i.e., a positive indirect effect). Conclusions Craving is linked to increased levels of psychological challenge when the object of the craving can be obtained, but it is unrelated to craving when it is not. The research also highlights the importance of desire thinking as an important, but complex, mediator in the relationship between craving and motivational states: desire thinking inhibited challenge when anticipating craving fulfillment, but encouraging it during the process of fulfillment itself. Level of evidence I: Evidence obtained from at least one properly designed randomized controlled trial.

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Effects of amphetamine on the plus-maze discriminative avoidance task in mice

Cited by 39 publications

References 53 publications

Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish

Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish

Preventive Effect of Baicalein on Methamphetamine-Induced Amnesia in the Passive Avoidance Test in Mice

The effects of food craving and desire thinking on states of motivational challenge and threat and their physiological indices

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