Effects of aminophylline on cognitive recovery after sevoflurane anesthesia

Abstract

The administration of escalating doses of aminophylline accelerates postoperative cognitive recovery from sevoflurane anesthesia, as measured by the SOMCT, due to increased ventilatory elimination of sevoflurane.

A Comparison of the Effects of Low and High Doses of Aminophylline on Recovery Time and the Bispectral Index Score Following Iso flurane Anesthesia

“…Escalating doses of aminophylline have been used in many studies; El Tahan administered 2, 3, 4, and 5 mg/kg of aminophylline after sevoflurane and total intravenous anesthesia, which accelerated the patients' postoperative cognitive recovery, induced higher respiratory rate values and lower sedation scores, and shortened the times to eye opening, extubation, achievement of an Aldrete score ≥ 9, and PACU discharge after ambulatory surgeries (20,24,25). The type of operation in many of these trials was a non-laparotomy procedure with a short duration, which raised a major question: In our study, why did aminophylline increase the recovery period after laparotomies that used isoflurane anesthesia?…”

Postoperative Cognitive Dysfunction: Preclinical Highlights and Perspectives on Preventive Strategies

“…Aminophylline reduced the time necessary for postoperative cognitive recovery from sevolurane anaesthesia, improving the ventilatory elimination of sevolurane [67]. Meanwhile, low-dose haloperidol prophylactic treatment did not prove efective in decreasing the incidence of postoperative delirium but had a positive efect on the severity and duration [68].…”

Management of cognition as reported in Japanese historical documents and modern anesthesiology research papers

“…Several drugs, including aminophylline, haloperidol, donepezil and gabapentine have been evaluated and shown to have relatively minor ameliorating effects on cognitive impairment after general anesthesia [23][24][25][26]. Proper visual and hearing equipment, attention to preoperative pain, early mobilization, avoiding physical restraints, treatment of electrolyte imbalance and fluid deficit, ensuring normal sleep−awake cycles, and inclusion of family in the postoperative care plan, are other important factors in a smooth return to normal cognition after surgery [27].…”