Effects of amiloride on acetylcholine‐dependent arterial vasodilation evolve over time in mice on a high salt diet

Mutchler, Stephanie; Kleyman, Thomas R.

doi:10.14814/phy2.15255

Cited by 2 publications

(1 citation statement)

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“…Deletion of gENaC subunit in endothelial cells did not protect against renal ischemia reperfusion injury [33]. However, whether ENaC inhibits nitric oxide production thereby mediating vascular tone and myogenic response or rather helps preserving a homeostatic response still needs to be evaluated [63]. Kirabo et al [64] demonstrated a novel role for ENaC in immune cells and its contribution to saltinduced inflammation and hypertension.…”

Section: Extrarenal Expression Of Epithelial Sodium Channel and Blood...mentioning

confidence: 99%

Lessons learned about epithelial sodium channels from transgenic mouse models

Ehret

Hummler

2022

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewThis review provides an up-to-date understanding about the regulation of epithelial sodium channel (ENaC) expression and function. In particular, we will focus on its implication in renal Na+ and K+ handling and control of blood pressure using transgenic animal models.Recent findingsIn kidney, the highly amiloride-sensitive ENaC maintains whole body Na+ homeostasis by modulating Na+ transport via epithelia. This classical role is mostly confirmed using genetically engineered animal models. Recently identified key signaling pathways that regulate ENaC expression and function unveiled some nonclassical and unexpected channel regulatory processes. If aberrant, these dysregulated mechanisms may also result in the development of salt-dependent hypertension.The purpose of this review is to highlight the most recent findings in renal ENaC regulation and function, in considering data obtained from animal models.SummaryIncreased ENaC-mediated Na+ transport is a prerequisite for salt-dependent forms of hypertension. To treat salt-sensitive hypertension it is crucial to fully understand the function and regulation of ENaC.

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Section: Extrarenal Expression Of Epithelial Sodium Channel and Blood...mentioning

confidence: 99%

Lessons learned about epithelial sodium channels from transgenic mouse models

Ehret

Hummler

2022

Current Opinion in Nephrology &Amp; Hypertension

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Epithelial Na ⁺ Channels Function as Extracellular Sensors

Kashlan,

Wang,

Sheng

et al. 2024

Comprehensive Physiology

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The epithelial Na + channel (ENaC) resides on the apical surfaces of specific epithelia in vertebrates and plays a critical role in extracellular fluid homeostasis. Evidence that ENaC senses the external environment emerged well before the molecular identity of the channel was reported three decades ago. This article discusses progress toward elucidating the mechanisms through which specific external factors regulate ENaC function, highlighting insights gained from structural studies of ENaC and related family members. It also reviews our understanding of the role of ENaC regulation by the extracellular environment in physiology and disease. After familiarizing the reader with the channel's physiological roles and structure, we describe the central role protein allostery plays in ENaC's sensitivity to the external environment. We then discuss each of the extracellular factors that directly regulate the channel: proteases, cations and anions, shear stress, and other regulators specific to particular extracellular compartments. For each regulator, we discuss the initial observations that led to discovery, studies investigating molecular mechanism, and the physiological and pathophysiological implications of regulation. © 2024 American Physiological Society. Compr Physiol 14:5407‐5447, 2024.

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Effects of amiloride on acetylcholine‐dependent arterial vasodilation evolve over time in mice on a high salt diet

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 2 publications

References 58 publications

Lessons learned about epithelial sodium channels from transgenic mouse models

Lessons learned about epithelial sodium channels from transgenic mouse models

Epithelial Na ⁺ Channels Function as Extracellular Sensors

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Effects of amiloride on acetylcholine‐dependent arterial vasodilation evolve over time in mice on a high salt diet

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 2 publications

References 58 publications

Lessons learned about epithelial sodium channels from transgenic mouse models

Lessons learned about epithelial sodium channels from transgenic mouse models

Epithelial Na + Channels Function as Extracellular Sensors

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Product

Resources

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Epithelial Na ⁺ Channels Function as Extracellular Sensors