Effects of ambient temperatures between 5 and 35 °C on energy balance, body mass and body composition in mice

Zhao, Zhanzheng; Yang, Rui; Li, Min; Bao, Meng-Huan; Huo, Da-Liang; Cao, Jing; Speakman, John R.

doi:10.1016/j.molmet.2022.101551

Cited by 19 publications

(10 citation statements)

References 93 publications

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“…Previous studies reported that body weight gain was suppressed and body fat mass was decreased in mice and humans when BAT was activated or increased by cold stimulation [29][30][31]. In this study, body weight gain of rats reared under cold-stimulated conditions was also suppressed lower than that in control conditions.…”

Section: Discussionsupporting

confidence: 50%

Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy

Iida,

Ueda,

Tsukada

et al. 2023

Journal of Biophotonics

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Brown adipose tissue (BAT) is related to lipid and glucose metabolism, and BAT evaluation is expected to contribute to disease prevention and treatment. We aimed to establish a BAT evaluation method using simple and non‐invasive diffuse reflectance spectroscopy (DRS). We acquired diffuse reflectance spectra of BAT using DRS from rats with cold stimulation and analyzed the second‐derivative spectra. To predict the amount of triglyceride in BAT from the second‐derivative spectra, partial least‐squares regression analysis was performed, and we examined whether BAT weight can be predicted from the amount of triglyceride by single regression analysis. By focusing on changes in the amount of triglyceride in BAT with cold stimulation, it was suggested that this amount could be predicted spectroscopically, and the predicted amount of triglyceride could be used to estimate the BAT weight with cold stimulation. If these results can be translated into humans, they may contribute to preventing metabolic disorders.This article is protected by copyright. All rights reserved.

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Section: Discussionsupporting

confidence: 50%

Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy

Iida,

Ueda,

Tsukada

et al. 2023

Journal of Biophotonics

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“…During short exposures to cold, an almost perfect fit is shown, with intake adjustment compensating accurately for temperature-induced changes in expenditure. In contrast, during long-term cold exposures, the rise in food intake is insufficient to compensate for the increased metabolic output ( 169 , 178 , 179 ), resulting in a progressive reduction of fat mass. Conversely, when environmental temperatures get warmer and close to the TNZ, intake is progressively suppressed, but this reduction is lower than the decrease observed in energy expenditure, particularly in the case of highly tasty foods ( 169 ).…”

Section: Impact Of Thermoregulation On Energy Homeostasis: Importance...mentioning

confidence: 99%

“…Furthermore, the study of the metabolic effects of cold ambient temperatures, including the activation of cold thermosensors is an emerging field with great physiological and medical interest. Thus, accumulating evidence indicate that mice exposition to cold temperatures induce loss of fat mass in animals fed a standard or a high fat diet, with a significant activation of BAT and WAT browning ( 178 , 179 ). Contrarily, mice deficient in TRPM8 (the main cold sensor) develop obesity when housed at mild temperatures, exhibiting diurnal hyperphagia, reduced lipid utilization ( 70 ) and an altered circadian physiology ( 14 ).…”

Section: Impact Of Thermoregulation On Energy Homeostasis: Importance...mentioning

confidence: 99%

“…Consequently, the metabolic impact of cold temperature on energy balance will be observed at higher ambient temperatures in females than in males. Indeed, a recent study showed that housing female mice for two weeks below 25 °C induced a decrease in fat mass, while only temperatures below 18 °C produced a reduction of white adipose tissue in males ( 179 ). Further research is warranted to investigate in humans the effectiveness of chronic stimulation of cold temperature signalling pathways on fat loss, glucose and lipid homeostasis and evaluate the threshold differences between both sexes.…”

Section: Impact Of Thermoregulation On Energy Homeostasis: Importance...mentioning

confidence: 99%

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Sex differences in thermoregulation in mammals: Implications for energy homeostasis

Fernández‐Peña

Reimúndez²,

Viana³

et al. 2023

Front. Endocrinol.

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Thermal homeostasis is a fundamental process in mammals, which allows the maintenance of a constant internal body temperature to ensure an efficient function of cells despite changes in ambient temperature. Increasing evidence has revealed the great impact of thermoregulation on energy homeostasis. Homeothermy requires a fine regulation of food intake, heat production, conservation and dissipation and energy expenditure. A great interest on this field of research has re-emerged following the discovery of thermogenic brown adipose tissue and browning of white fat in adult humans, with a potential clinical relevance on obesity and metabolic comorbidities. However, most of our knowledge comes from male animal models or men, which introduces unwanted biases on the findings. In this review, we discuss how differences in sex-dependent characteristics (anthropometry, body composition, hormonal regulation, and other sexual factors) influence numerous aspects of thermal regulation, which impact on energy homeostasis. Individuals of both sexes should be used in the experimental paradigms, considering the ovarian cycles and sexual hormonal regulation as influential factors in these studies. Only by collecting data in both sexes on molecular, functional, and clinical aspects, we will be able to establish in a rigorous way the real impact of thermoregulation on energy homeostasis, opening new avenues in the understanding and treatment of obesity and metabolic associated diseases.

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“…Metabolism, such as oxygen consumption and energy use, is affected by ambient temperature (Seeley and MacDougald, 2021; Zhao et al, 2022). However, despite oxygen consumption decreases at warm temperature, changing the ambient temperature is insufficient to alter glucose tolerance and fasting insulin levels in lean mice (Clayton and McCurdy, 2018; Dudele et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Body temperature regulates glucose metabolism and torpid behavior

Lee,

Chang,

Toda

et al. 2024

Preprint

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Glucose is a significant energy resource for maintaining physiological activities, including body temperature homeostasis, and glucose homeostasis is tightly regulated in mammals. Although ambient temperature tunes glucose metabolism to maintain euthermia, the significance of body temperature in metabolic regulation remains unclear owing to strict thermoregulation. Activation of Qrfp neurons in the preoptic area induced a harmless hypothermic state known as Q-neuron-induced hypothermia and hypometabolism (QIH), which is suitable for studying glucose metabolism under hypothermia. In this study, we first observed that QIH mice had hyperinsulinemia and insulin resistance. This glucose hypometabolic state was abolished by increasing the body temperature to euthermia. Moreover, QIH-mediated inappetence and locomotor inactivity were recovered in euthermia QIH mice. These results indicate that body temperature is considerably more powerful than ambient temperature in regulating glucose metabolism and behavior, and hypometabolism in QIH is secondary to hypothermia rather than modulated by Qrfp neurons.

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Effects of ambient temperatures between 5 and 35 °C on energy balance, body mass and body composition in mice

Cited by 19 publications

References 93 publications

Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy

Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy

Sex differences in thermoregulation in mammals: Implications for energy homeostasis

Body temperature regulates glucose metabolism and torpid behavior

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