Effects of ambient particulate matter on vascular tissue: a review

Shkirkova, Kristina; Lamorie‐Foote, Krista; Connor, Michelle; Patel, Arati; Barisano, Giuseppe; Baertsch, Hans; Liu, Qinghai; Morgan, Todd E.; Sioutas, Constantinos; Mack, William J.

doi:10.1080/10937404.2020.1822971

Cited by 52 publications

(20 citation statements)

References 188 publications

(188 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traffic-related emissions are one of the most important sources of particulate matter (PM) in urban environments. Exposure to the traffic-related fine PM is often associated with adverse health effects and oxidative stress. − Within the past two decades, many countries have implemented stringent regulations leading to a significant reduction in exhaust or tailpipe emissions and PM mass concentrations. − In contrast, nonexhaust emissions from brakes, tires, and road wear are currently not regulated, but their importance in urban air quality has been increasingly recognized. − Correlation analyses from recent studies suggest that nonexhaust emissions also contribute to fine PM toxicity, highlighting the importance of investigating relations among sources, chemical composition, and particle toxicity. , Recent epidemiological studies have shown strong associations of long-term exposure to nontailpipe emissions with respiratory and cardiovascular diseases. , …”

Section: Introductionmentioning

confidence: 99%

Environmentally Persistent Free Radicals, Reactive Oxygen Species Generation, and Oxidative Potential of Highway PM_2.5

Hwang

Fang

Pham

et al. 2021

ACS Earth Space Chem.

View full text Add to dashboard Cite

In urban environments, vehicle exhaust and nonexhaust emissions represent important sources of fine particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5), which plays a central role in adverse health effects and oxidative stress. We collected PM2.5 filter samples from two highway sites (Anaheim and Long Beach, CA) and an urban site (Irvine, CA) to quantify environmentally persistent free radicals (EPFRs) contained in PM2.5 and the generation of radical forms of reactive oxygen species (ROS) in water using electron paramagnetic resonance spectroscopy. The EPFR concentrations were 36 ± 14 pmol m–3 at highway sites, which were about two times higher than those at the urban site. EPFRs correlate positively well with CO, NOx, and elemental and organic carbon, indicating that EPFRs are emitted from vehicular exhaust. Good correlations of EPFRs and Fe and Cu may indicate that EPFRs are stabilized by Fe and Cu emitted from tire and brake wears. EPFRs are negatively correlated with ozone, suggesting that photochemistry does not play a large role in the formation of EPFRs and possibly also indicating that EPFRs are quenched by ozone. Highway PM2.5 are found to generate mainly OH and organic radicals in the aqueous phase. The generated ROS are correlated with PM2.5 mass concentrations and OH radicals show a good correlation with EPFRs, implying the role of EPFRs in aqueous OH radical generation. The PM2.5 oxidative potentials as quantified with the dithiothreitol (DTT) assay are correlated with ROS, OH, and organic radicals for PM2.5 collected in Anaheim, whereas little correlations are observed for Long Beach. These findings highlight the interplay of various PM redox-active chemical components and complex relationship between ROS formation and DTT activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Environmentally Persistent Free Radicals, Reactive Oxygen Species Generation, and Oxidative Potential of Highway PM_2.5

Hwang

Fang

Pham

et al. 2021

ACS Earth Space Chem.

View full text Add to dashboard Cite

show abstract

“…It should be mentioned that recent studies particularly underline negative impact of ultrafine particles (UFP, diameter below 0.1 µm) in the air on various body organs (see e.g., Bevan et al, 2020;Daiber et al, 2020;Niu et al, 2020;Shkirkova et al, 2020). Unfortunately, continuous field measurements of the UFP level in the air are conducted very rarely.…”

Section: Health Risk Related To Marathon Runningmentioning

confidence: 99%

Marathon race performance increases the amount of particulate matter deposited in the respiratory system of runners: an incentive for “clean air marathon runs”

Zoladz

Nieckarz

2021

PeerJ

View full text Add to dashboard Cite

Background In the last decades, marathon running has become a popular form of physical activity among people around the world. It should be noticed that the main marathon races are performed in large cities, where air quality varies considerably. It is well established that breathing polluted air results in a number of harmful effects to the human body. However, there have been no studies to show the impact of marathon run performance on the amount of the deposition of varied fractions of airborne particulate matter (PM) in the respiratory tract of runners. This is why the present study sought to determine the impact of marathon run performance in the air of varying quality on the deposition of the PM1, PM2.5, PM10 in the respiratory tract in humans. Methods The PM1, PM2.5 and PM10 deposition was determined in an “average runner” (with marathon performance time 4 h: 30 min) and in an “elite marathon runner” (with marathon performance time 2 h: 00 min) at rest, and during a marathon race, based on own measurements of the PM content in the air and the size-resolved DF(d) profile concept. Results We have shown that breathing air containing 50 µg m−3 PM10 (a borderline value according to the 2006 WHO standard - still valid) at minute ventilation (VE) equal to 8 L min−1 when at rest, resulted in PM10deposition rate of approximately 9 µg h−1, but a marathon run of an average marathon runner with the VE = 62 L min−1 increased the deposition rate up to 45 µg h−1. In the elite runner, marathon run with the VE= 115 L min−1 increased PM10 deposition rate to 83 µg h−1. Interestingly, breathing the air containing 50 µg m−3of PM10 at the VE = 115 L min−1by the elite marathon runner during the race resulted in the same PM10deposition rate as the breathing highly polluted air containing as much as 466 µg m−3 of PM10 when at rest. Furthermore, the total PM10 deposition in the respiratory tract during a marathon race in average runners is about 22% greater (203 / 166 = 1.22) than in elite runners. According to our calculations, the concentration of PM10in the air during a marathon race that would allow one not to exceed the PM10 deposition rate of 9 µg h−1should be lower than 10 µg m−3 in the case of an average runner, and it should be lower than 5.5 µg m−3 in the case of an elite runner. Conclusions We conclude that a marathon run drastically increases the rate of deposition of the airborne PM in the respiratory tract of the runners, as a consequence of the huge VE generated during the race. A decrease of the PM content in the air attenuates this rate. Based on our calculations, we postulate that the PM10 content in the air during a “clean air marathon run”, involving elite marathon runners, should be below 5.5 µg m−3.

show abstract

“…Past evidence has demonstrated that PM could induce oxidative stress [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], result in DNA damage [ 25 , 28 , 29 ], and activate local and systemic inflammatory response [ 22 , 23 , 25 , 26 , 30 ]. Furthermore, PM has also been shown to impair vascular function [ 30 , 31 ], increase the expression of vascular inflammatory biomarkers, including intercellular adhesion molecules (ICAM-1), vascular cell adhesion molecules (VCAM-1), and P-selectin [ 24 , 32 ]. VCAM-1 and ICAM-1 and p-selectin are vascular adhesion molecules that play an important role in thrombus formation by promoting leukocyte-endothelial and leukocyte-platelet interaction during the inflammatory response [ 24 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Particulate Matter on Inflammation and Thrombosis: Past Evidence for Future Prevention

Hantrakool

Kumfu

Chattipakorn

et al. 2022

IJERPH

View full text Add to dashboard Cite

Ambient air pollution has become a common problem worldwide. Exposure to pollutant particles causes many health conditions, having a particular impact on pulmonary and cardiovascular disease. Increased understanding of the pathological processes related to these conditions may facilitate the prevention of the adverse impact of air pollution on our physical health. Evidence from in vitro, in vivo, and clinical studies has consistently shown that exposure to particulate matter could induce the inflammatory responses such as IL-6, TNF-α, IL-1β, as well as enhancing the oxidative stress. These result in vascular injury, adhesion molecule release, platelet activation, and thrombin generation, ultimately leading to a prothrombotic state. In this review, evidence on the effects of particulate matter on inflammation, oxidative stress, adhesion molecules, and coagulation pathways in enhancing the risk of thrombosis is comprehensively summarized and discussed. The currently available outcomes of interventional studies at a cellular level and clinical reports are also presented and discussed.

show abstract

Effects of ambient particulate matter on vascular tissue: a review

Cited by 52 publications

References 188 publications

Environmentally Persistent Free Radicals, Reactive Oxygen Species Generation, and Oxidative Potential of Highway PM_2.5

Environmentally Persistent Free Radicals, Reactive Oxygen Species Generation, and Oxidative Potential of Highway PM_2.5

Marathon race performance increases the amount of particulate matter deposited in the respiratory system of runners: an incentive for “clean air marathon runs”

Effects of Particulate Matter on Inflammation and Thrombosis: Past Evidence for Future Prevention

Contact Info

Product

Resources

About

Effects of ambient particulate matter on vascular tissue: a review

Cited by 52 publications

References 188 publications

Environmentally Persistent Free Radicals, Reactive Oxygen Species Generation, and Oxidative Potential of Highway PM2.5

Environmentally Persistent Free Radicals, Reactive Oxygen Species Generation, and Oxidative Potential of Highway PM2.5

Marathon race performance increases the amount of particulate matter deposited in the respiratory system of runners: an incentive for “clean air marathon runs”

Effects of Particulate Matter on Inflammation and Thrombosis: Past Evidence for Future Prevention

Contact Info

Product

Resources

About

Environmentally Persistent Free Radicals, Reactive Oxygen Species Generation, and Oxidative Potential of Highway PM_2.5

Environmentally Persistent Free Radicals, Reactive Oxygen Species Generation, and Oxidative Potential of Highway PM_2.5