Effects of altered parental folate and one-carbon nutrient status on offspring growth and metabolism

Crott, Jimmy W.

doi:10.1016/j.mam.2016.11.001

Cited by 9 publications

(9 citation statements)

References 58 publications

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“…Our results are consistent with a study which has reported up-regulation of DNMTs under folate and methionine deficient diet 24 . Early life programming is dependent on genomic imprinting which is established in a parent of origin- specific manner based on DNA methylation and any alterations in methylation state can affect the imprinting status of developing fetus 55 . This suggests that the maternal dietary factors regulating the state of DNA methylation and DNMTs are imperative to study considering the importance of imprinting genes in the development.…”

Section: Discussionmentioning

confidence: 99%

Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs

Mahajan

Sapehia

Thakur

et al. 2019

Sci Rep

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DNA methylation, a central component of the epigenetic network is altered in response to nutritional influences. In one-carbon cycle, folate acts as a one-carbon carrier and vitamin B12 acts as co-factor for the enzyme methionine synthase. Both folate and vitamin B12 are the important regulators of DNA methylation which play an important role in development in early life. Previous studies carried out in this regard have shown the individual effects of these vitamins but recently the focus has been to study the combined effects of both the vitamins during pregnancy. Therefore, this study was planned to elucidate the effect of the altered dietary ratio of folate and B12 on the expression of transporters, related miRNAs and DNA methylation in C57BL/6 mice. Female mice were fed diets with 9 combinations of folate and B12 for 4 weeks. They were mated and off-springs born (F1) were continued on the same diet for 6 weeks post-weaning. Maternal and fetal (F2) tissues were collected at day 20 of gestation. Deficient state of folate led to an increase in the expression of folate transporters in both F1 and F2 generations, however, B12 deficiency (BDFN) also led to an increase in the expression in both the generations. B12 transporters/proteins were found to be increased with B12 deficiency in F1 and F2 generations except for TC-II in the kidney which was found to be decreased in the F1 generation. miR-483 was found to be increased with all conditions of folate and B12 in both F1 and F2 generations, however, deficient conditions of B12 led to an increase in the expression of miR-221 in both F1 and F2 generations. The level of miR-133 was found to be increased in BDFN group in F1 generation however; in F2 generation the change in expression was tissue and sex-specific. Global DNA methylation was decreased with deficiency of both folate and B12 in maternal tissues (F1) but increased with folate deficiency in placenta (F1) and under all conditions in fetal tissues (F2). DNA methyltransferases were overall found to be increased with deficiency of folate and B12 in both F1 and F2 generations. Results suggest that the dietary ratio of folate and B12 resulted in altered expression of transporters, miRNAs, and genomic DNA methylation in association with DNMTs.

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Section: Discussionmentioning

confidence: 99%

Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs

Mahajan

Sapehia

Thakur

et al. 2019

Sci Rep

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“…Since the 80s, it is recognized that maternal folate deficiency is associated with NTD and more subtle changes in offspring development [ 4 ]. A lowered maternal folate status has other consequences in offspring, such as intrauterine growth retardation, low birth weight, hyperglycemia, and insulin resistance (reviewed in [ 5 ]). There are emerging shreds of evidence that paternal folate intake also impacts the offspring’s health and disease onset.…”

Section: Impact Of Paternal Folic Acid Intake On Progeny’s Healthmentioning

confidence: 99%

“…These observations led to the World Health Organization (WHO) current recommendations, according to which all women should take a daily folic acid supplement from the pre-conceptional period until 12 weeks of gestation to prevent NTD [ 4 ]. Alteration of the maternal folate status also has consequences on birth weight, glucose blood levels, and insulin resistance (reviewed in [ 5 ]). Our previous work using a unique, well-defined animal model based on rats born from dams fed a methyl-deficient diet during gestation and lactation reported neurosteroidogenesis and epigenetic alterations associated with cognitive and motor disorders during offspring postnatal cerebral development [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Consequences of Paternal Nutrition on Offspring Health and Disease

et al. 2021

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It is well established that the maternal diet during the periconceptional period affects the progeny’s health. A growing body of evidence suggests that the paternal diet also influences disease onset in offspring. For many years, sperm was considered only to contribute half of the progeny’s genome. It now appears that it also plays a crucial role in health and disease in offspring’s adult life. The nutritional status and environmental exposure of fathers during their childhood and/or the periconceptional period have significant transgenerational consequences. This review aims to describe the effects of various human and rodent paternal feeding patterns on progeny’s metabolism and health, including fasting or intermittent fasting, low-protein and folic acid deficient food, and overnutrition in high-fat and high-sugar diets. The impact on pregnancy outcome, metabolic pathways, and chronic disease onset will be described. The biological and epigenetic mechanisms underlying the transmission from fathers to their progeny will be discussed. All these data provide evidence of the impact of paternal nutrition on progeny health which could lead to preventive diet recommendations for future fathers.

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“…Consequently, those functions of the GI tract and its microbiome that support methylation capacity are essential for normal development. Vitamin B12 (cobalamin) and folic acid (folate) are two of the most important nutritional factors for methylation and their efficient absorption is essential for normal epigenetic regulation and postnatal development ( DeVilbiss et al, 2015 ; Athanasopoulos et al, 2016 ; Crott, 2017 ). Folate is produced by bacteria for their own metabolic needs, but only certain bacterial strains (e.g., Bifidobacterium and Lactobacillus ) are capable of producing vitamin B12, setting up competition between microbes and intestinal epithelial cells in the distal ileum, the primary site of B12 absorption ( Degnan et al, 2014 ).…”

Section: Biological Mechanisms Associated With Autismmentioning

confidence: 99%

Early Disruption of the Microbiome Leading to Decreased Antioxidant Capacity and Epigenetic Changes: Implications for the Rise in Autism

Eshraghi

Deth

Mittal

et al. 2018

Front. Cell. Neurosci.

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Currently, 1 out of every 59 children in the United States is diagnosed with autism. While initial research to find the possible causes for autism were mostly focused on the genome, more recent studies indicate a significant role for epigenetic regulation of gene expression and the microbiome. In this review article, we examine the connections between early disruption of the developing microbiome and gastrointestinal tract function, with particular regard to susceptibility to autism. The biological mechanisms that accompany individuals with autism are reviewed in this manuscript including immune system dysregulation, inflammation, oxidative stress, metabolic and methylation abnormalities as well as gastrointestinal distress. We propose that these autism-associated biological mechanisms may be caused and/or sustained by dysbiosis, an alteration to the composition of resident commensal communities relative to the community found in healthy individuals and its redox and epigenetic consequences, changes that in part can be due to early use and over-use of antibiotics across generations. Further studies are warranted to clarify the contribution of oxidative stress and gut microbiome in the pathophysiology of autism. A better understanding of the microbiome and gastrointestinal tract in relation to autism will provide promising new opportunities to develop novel treatment modalities.

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Effects of altered parental folate and one-carbon nutrient status on offspring growth and metabolism

Cited by 9 publications

References 58 publications

Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs

Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs

Consequences of Paternal Nutrition on Offspring Health and Disease

Early Disruption of the Microbiome Leading to Decreased Antioxidant Capacity and Epigenetic Changes: Implications for the Rise in Autism

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