Effects of alpha‐lipoic acid supplementation on growth performance, antioxidant capacity and biochemical parameters for ammonia‐exposed broilers

Lü, Min; Bai, Jie; Wei, Fengying; Xu, Bin; Sun, Quanyou; Li, Jie; Wang, Gaili; Tang, Xiangfang; Zhang, Hongfu; Yin, Qingqiang; Li, Shaoyu

doi:10.1111/asj.12759

Cited by 11 publications

(10 citation statements)

References 29 publications

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“…It has been demonstrated that the degree of lipid peroxidation in cells and tissues is positively correlated with MDA production (Zhang et al 2019). Moreover, it was reported that ALA addition significantly inhibited the lipid peroxidation of ammonia-exposed broilers by suppressing MDA production (Lu et al 2017). The MDA content was significantly increased in the rat ovary which had suffered oxidative damage (Kulhan et al 2019).…”

Section: Effect Of Ala On Er Stress and Hsp70 Protein Expression In The Ovaries Of Hens Exposed To Heat Stressmentioning

confidence: 98%

Alpha lipoic acid improves heat stress-induced reduction of serum oestradiol and progesterone levels by affecting oxidative and endoplasmic reticulum stress in hens

Xiong¹,

Yin²,

Song³

et al. 2021

CZECH J ANIM SCI

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Alpha lipoic acid (ALA), a natural lipophilic compound, plays an important role in regulating several metabolic pathways due to its antioxidant properties. This study aims to investigate whether ALA could be used as a feed additive to enhance the antioxidant capacity of the ovary tissue in hens exposed to heat stress (HS). One hundred and sixty 128-days-old female chickens were randomly assigned into four groups: the control group (Con), ALA treatment group (ALA), ALA and HS treatment group (ALA + HS), and HS treatment group (HS). The ALA and ALA + HS groups were fed a basal diet with 0.25% ALA, whereas the Con and HS groups were fed a basal diet only. Serum oestradiol, progesterone levels, biomarkers of antioxidant capacity, and endoplasmic reticulum (ER) stress markers were detected in the ovaries of heat-stressed chickens. HS decreased serum oestradiol and progesterone concentrations compared with the control group, whereas dietary ALA (0.25%) increased oestradiol and progesterone levels in the serum of heat-stressed hens. Malondialdehyde concentration in the ovary was higher in the HS group than that of the ALA + HS group. Compared with the HS group, ALA increased the enzymatic activities of superoxide dismutase, glutathione peroxidase, and catalase in the ovaries of ALA + HS group. Simultaneously, ALA enhanced the total antioxidative capacity of the ovaries of heat-stressed hens. Moreover, ALA also significantly inhibited the increased expression of glucose-regulated protein 78 and CCAAT/enhancer-binding protein homologous protein, which are two markers of ER stress, and heat shock protein 70, a key biomarker of heat stress, in the ovaries of the ALA + HS group as compared to those of the HS group. This work implied that dietary ALA supplementation improved the antioxidant capacity and attenuated the HS-induced reduction of serum oestradiol and progesterone levels and modulated the oxidative and ER stress, which are involved in the protective effect of ALA in hens exposed to hyperthermia.

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Section: Effect Of Ala On Er Stress and Hsp70 Protein Expression In The Ovaries Of Hens Exposed To Heat Stressmentioning

confidence: 98%

Alpha lipoic acid improves heat stress-induced reduction of serum oestradiol and progesterone levels by affecting oxidative and endoplasmic reticulum stress in hens

Xiong¹,

Yin²,

Song³

et al. 2021

CZECH J ANIM SCI

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“…Wang et al (2019a) found that NH3 exposure could cause oxidative stress, intestinal inflammation and disrupt the chicken intestine integrity. Previous findings have shown that a high concentration of NH 3 increased serum biochemical indices such as AST, ALT, AKP, GGT, CK and ALB in chickens, which signified a negative effect on the immune organs (Lu et al, 2017;Shah et al, 2020). Liu et al (2020) indicated that exposure of chickens to a high concentration of NH 3 disrupted the ecological balance of the lung tissue flora, increased some pathogenic bacteria such as Escherichia/Shigella and damaged their lung tissue.…”

Section: Environmental Pollutantsmentioning

confidence: 98%

Environmental Stress in Chickens and the Potential Effectiveness of Dietary Vitamin Supplementation

Akinyemi

Adewole

2021

Front. Anim. Sci.

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Environmental stressors can promote the vulnerability of animals to infections; it is therefore, essential to understand how stressors affect the immune system, the adaptive capacity of animals to respond, and effective techniques in managing stress. This review highlights scientific evidence regarding environmental stress challenge models and the potential effectiveness of vitamin supplementation. The major environmental stressors discussed are heat and cold stress, feed restriction, stocking density, and pollutants. Much work has been done to identify the effects of environmental stress in broilers and layers, while few involved other types of poultry. Studies indicated that chickens' performance, health, and welfare are compromised when challenged with environmental stress. These stressors result in physiological alterations, behavioral changes, decreased egg and meat quality, tissue and intestinal damage, and high mortalities. The application of vitamins with other nutritional approaches can help in combating these environmental stressors in chickens. Poultry birds do not synthesize sufficient vitamins during stressful periods. It is therefore suggested that chicken diets are supplemented with vitamins when subjected to environmental stress. Combination of vitamins are considered more efficient than the use of individual vitamins in alleviating environmental stress in chickens.

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“…Moreover, low feed consumption following ALA treatment cannot be attributed to the dietary taste as ALA injection treatment resulted a similar situation . On the other hand, positive effects of ALA supplementation on body weight and feed utilization were reported (Lu et al, 2017;Yoo et al, 2016). In addition, Zhang et al (2009) reported no marked effect of ALA on FCR.…”

Section: Growth Performance and Nutrient Utilizationmentioning

confidence: 99%

“…Various studies have shown the body weight, weight gain and feed intake of broiler chicks were significantly decreased by increasing the supplementation level of ALA (Arshad et al, 2013;Elsenousey et al, 2013 andZhang et al, 2014). On the opposite direction, ; Yoo et al (2016) and Lu et al (2017) reported that body weight, weight gain and feed conversion ratio were significantly improved by ALA by decreasing the supplementation level of ALA.…”

Section: Introductionmentioning

confidence: 98%

ASSESSMENT OF THE EFFECT OF Α-Lipoic ACID SUPPLEMENTATION TO THE DIET WITH DIFFERENT DIETARY ENERGY LEVELS ON BROILER PERFORMANCE AND ATIOXIDANTS STATUS

El-Rayes

2020

Egyptian Journal of Nutrition and Feeds

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he present study aimed to assess if there is any synergistic or antagonistic effect between α-lipoic acid (ALA) and dietary energy levels in increasing growth performance traits as well as minimizing fat deposition of broiler. Three hundred and sixty one-day-old unsexed Cobb broilers chicks were assigned randomly to 8 equal experimental groups; with three replicates of 15 chicks each. The feeding consists of three stages; the first was (starting period), its basal diet contained 22 % CP and lasted for 3 weeks. The second was (growing period), its basal diet contained 20 % CP and lasted for 2 weeks. The third period was (finishing period), its basal diet contained 18 % CP at the last week of the experiment. Within each protein level used, two levels of energy (3000 and 3200 Kcal / kg diet) were tested with various levels of α-lipoic acid (0, 50, 75 and 100 mg / kg diet). So, the experimental design was a factorial 2 energy levels × 4 α-lipoic acid levels. Results showed that, Significant effects of α-Lipoic acid, diet energy levels and their interaction on chicks weight gain (WG), feed consumption (FC), and feed conversion ratio (FCR). Significant declines in dressing, front part, hind part, giblets, and abdominal fat with increasing α-Lipoic acid level in the diet. Muscle (thigh and breast) antioxidants statuses were vary significantly with α-Lipoic acid, diet energy level, and their interaction. Overall, blood total lipids, triglycerides, and cholesterols have decreased significantly with increasing α-Lipoic acid levels. Moreover, only total lipids increased with increased dietary energy. Remarkable improvements were noticed in the plasma oxidative statues including TAC, SOD, GSHpx, and MDA. From the obtained results, it could be concluded that ɑ-lipoic acid supplementation at the level of 100 mg/kg diet provides significant natural antioxidant which boosts the oxidative status of meat and blood regardless the energy level in the diet.

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Effects of alpha‐lipoic acid supplementation on growth performance, antioxidant capacity and biochemical parameters for ammonia‐exposed broilers

Cited by 11 publications

References 29 publications

Alpha lipoic acid improves heat stress-induced reduction of serum oestradiol and progesterone levels by affecting oxidative and endoplasmic reticulum stress in hens

Alpha lipoic acid improves heat stress-induced reduction of serum oestradiol and progesterone levels by affecting oxidative and endoplasmic reticulum stress in hens

Environmental Stress in Chickens and the Potential Effectiveness of Dietary Vitamin Supplementation

ASSESSMENT OF THE EFFECT OF Α-Lipoic ACID SUPPLEMENTATION TO THE DIET WITH DIFFERENT DIETARY ENERGY LEVELS ON BROILER PERFORMANCE AND ATIOXIDANTS STATUS

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