Effects of Aloe Vera and Swimming Training on Lipid Profile of Streptozotocin Induced Diabetic Rats

Abstract

Background and Objectives: Exercise and nutrition are two effective factors in controlling diabetes-induced metabolic disorders. The aim of this study was to assess effects of aloe vera and swimming training on lipid profile of the diabetic rats. Materials and Methods: In this experimental study, 72 diabetic rats were selected and divided into nine groups of eight rats, including 1) four weeks of aloe vera consumption (FAV), 2) six weeks of aloe vera consumption (SAV), 3) four weeks of swimming (FS), 4) six weeks of swimming (SS), 5) four weeks of aloe vera consumption with swimming (FAVS), 6) six weeks of aloe vera consumption with swimming (SAVS), 7) Week-1 diabetic control (DC), 8) Week-4 diabetic control (FDC), and 9) Week-6 diabetic control (SDC). Groups 1, 2, 5 and 6 received 100 mg kg-1 of aloe vera daily. Furthermore, Groups 3 and 5 swam for four weeks and Groups 4 and 6 for six weeks, five sessions per week and 30 minutes each session. Data were analyzed using one-way ANOVA, two-way ANOVA and Bonferroni post-hoc tests (P≤0.05). Results: Results showed that training, aloe vera and aloe vera with training significantly decreased levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) (P≤0.05); four and six weeks of swimming trainings decreased TG, TC, LDL and VLDL (P≤0.05); and six weeks of aloe vera consumption decreased TG, TC, LDL and VLDL (P≤0.05). Conclusions: Four and six weeks of aloe vera consumption and swimming training include interactive lipid lowering effects in streptozotocin induced diabetic rats.

Potential protective effects of Aloe vera gel on cardiovascular diseases: A mini‐review

“…In an experimental study on streptozotocin‐induced diabetic rats, the hypolipidemic effects of AVG were evaluated. The findings of this study demonstrated that consumption of AVG for 6 weeks significantly decreased levels of TG, TC, LDL, and very‐low‐density lipoprotein cholesterol (VLDL) (Hosseini et al, 2020). Furthermore, AVG treatment at doses of 100 and 200 mg/kg/day showed beneficial effects against dyslipidemia and oxidative stress; also, prevented the accumulation of adipose tissue in obese rats (Rahoui et al, 2018).…”

Evaluating the Effects of Aloe vera Gel on Cerebellum Histomorphometrical Changes in Diabetic Male Rats

“…Bellamy et al (2006) reported that the induction of diabetes by STZ for eight weeks in rats caused cellular damage or cell loss in the cerebellum (13). Lechuga Sancho et al also showed that in diabetes, the activity of Caspase-3 cells continuously increases in all layers of the cerebellum, causing destruction, degeneration, and cellular changes in both glial (astrocyte, microglia) and purkinje cells, while the two above-mentioned cell groups form a common unit for the transmission of the synaptic information (26). During the diabetes period, the glucose consumption in the brain decreases, which causes the brain to become increasingly a vulnerable tissue (27).…”