Effects of Almond Dietary Supplementation on Coronary Heart Disease Lipid Risk Factors and Serum Lipid Oxidation Parameters in Men with Mild Hyperlipidemia

Abstract

These results demonstrated that almond supplementation, in addition to lowering effects on serum levels of CHD lipid risk factors, may contribute to a dramatic change in the relation of lipid risk factors and susceptibility of serum lipids to oxidative modification. This may be due to the distribution of different almond phenolic antioxidants in different components of serum including nonlipoprotein molecules such as serum albumin.

Statins and almonds to lower lipoproteins (the STALL Study)

“…9 However, similar to our study, Damasceno et al showed no effect on Lp(a) in 18 subjects consuming 50 to 75 g of almonds for 4 weeks, nor did Jalali-Khanabadi et al in 30 subjects consuming 60 g of almonds daily for 4 weeks. 13,24 This study demonstrated a statistically significant shift from pattern A (larger, buoyant LDL-C particles) to pattern B (smaller, dense LDL-C particles) (P 5 .003). This is an unexpected finding because several studies, including a recent study by Parlesak et al, demonstrated decreased small, dense LDL-C levels with increased MUFA consumption.…”

“…17 Our study also demonstrated that adding almonds to statin therapy produced favorable trends in LDL-C and TG. Several other studies have shown significant decreases in LDL-C with the addition of varying amounts of almonds, [9][10][11]13,14,[22][23][24][25] and a meta-analysis by Phung et al reported that almonds strongly trend toward significantly lowering LDL-C. 26 However, to our knowledge, none of these studies focused on subjects already taking statin therapy. In addition, subjects in the present study had a mean baseline LDL-C of 102 6 23 mg/dL.…”

Appetitive, dietary and health effects of almonds consumed with meals or as snacks: a randomized, controlled trial

“…Their fasting lipid profiles and blood pressure were within the healthy range at baseline. Previous studies that reported significant improvements often included participants with hyperlipidemia 50, 52, 53, 54, 55, 56 or type 2 diabetes. 36, 48, 57, 58 …”

Dietary Almonds Increase Serum HDL Cholesterol in Coronary Artery Disease Patients in a Randomized Controlled Trial

“…A meta-analysis of lipid-neutralizing potential concluded that dietary almonds decrease serum cholesterol, with a strong trend to lower LDL cholesterol [P-trend = 0.05), but do not affect HDL cholesterol (21). The almond trials included in this meta-analysis, as well as others reporting serum lipid concentrations, were conducted in participants who were normolipidemic (22)(23)(24)(25)(26)(27), prediabetic and/or diabetic (26,28,29), obese (30), and/or hyperlipidemic (31)(32)(33)(34), without having low HDL cholesterol at baseline. It seems desirable to investigate the HDL cholesterol-raising potential of almonds in a population that has low HDL cholesterol at baseline (35), such as South Asians.…”