Effects of almond consumption on lipid profile in patients with type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials

Wang, Ping; Sheng, Yingtao; Samadi, Mehnoosh

doi:10.1080/13813455.2021.1987477

Cited by 2 publications

(6 citation statements)

References 33 publications

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“…Numerous systematic reviews and meta-analyses of RCTs that evaluated nut consumption on blood lipid biomarkers have been published [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. Table 1 summarizes 19 selected studies.…”

Section: Effects Of Nuts On Blood Lipidsmentioning

confidence: 99%

“…Table 1 summarizes 19 selected studies. Three focused on interventions of both nuts and peanuts together [ 11 , 12 , 21 ], three were on tree nuts [ 16 , 18 , 22 ], five on almonds [ 13 , 15 , 19 , 25 , 29 ], four on walnuts [ 17 , 23 , 24 , 26 ], two on cashews [ 20 , 28 ], one on pistachios [ 27 ] and one on peanuts including peanut butter [ 14 ]. The doses tested varied from 5 to 200 g/d and the study durations were from 4 days to 2 years.…”

Section: Effects Of Nuts On Blood Lipidsmentioning

confidence: 99%

“…A consistent beneficial effect of almonds (10–168 g/d; 5–27 RCTs, n = 120–2,049 healthy or at risk of CVD individuals; 3–77 weeks duration) was reported in LDL-C (−0.15 to −0.18 mmol/L) [ 13 , 19 , 25 ], TC (−0.13 to −0.28 mmol/L) [ 19 , 25 ], and TG (−0.08 mmol/L) [ 25 ]. However, the evidence is less consistent in populations with type 2 diabetes [ 15 , 29 ]. Peanuts, although classified as a legume, have a comparable food matrix and fatty acid composition to those of tree nuts.…”

Section: Effects Of Nuts On Blood Lipidsmentioning

confidence: 99%

“…In 11 of the 19 included meta-analyses, subgroup analyses were conducted to examine the effect of higher vs. lower consumption of nuts on lipid/lipoprotein levels [ 11 , 13 , 15 , 16 , 17 , 19 , 21 , 23 , 25 , 26 , 29 ]. The highest consumption category was >63 g/d in one meta-analysis [ 26 ], ≥50 g/d in five meta-analyses [ 13 , 15 , 16 , 21 , 29 ], ≥45g/d in two meta-analyses [ 11 , 25 ], >42.5 g/d in one meta-analysis [ 19 ], ≥42 g/d in one meta-analysis [ 17 ], and ≥28 g/d in one meta-analysis [ 23 ]. In a meta-analysis of studies on healthy individuals, the consumption of ≥45 g/d of almonds lowered TC, LDL-C, and TG to a greater extent than <45 g/d [ 25 ].…”

Section: Effects Of Nuts On Blood Lipidsmentioning

confidence: 99%

“…In a meta-analysis of studies on healthy individuals, the consumption of ≥45 g/d of almonds lowered TC, LDL-C, and TG to a greater extent than <45 g/d [ 25 ]. Similarly, in a meta-analysis of five studies conducted in patients with type 2 diabetes, greater reductions in TC, LDL-C, HDL-C, and TG were observed with the consumption of ≥50 g/d of almonds [ 29 ]. In two meta-analyses including healthy participants and individuals at high risk for CVD, no effect modification by almond dose (≥50 g/d and >42 g/d) was observed [ 13 , 19 ].…”

Section: Effects Of Nuts On Blood Lipidsmentioning

confidence: 99%

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Effects of Nut Consumption on Blood Lipids and Lipoproteins: A Comprehensive Literature Update

et al. 2023

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In the present review, we provide a comprehensive narrative overview of the current knowledge on the effects of total and specific types of nut consumption (excluding nut oil) on blood lipids and lipoproteins. We identified a total of 19 systematic reviews and meta-analyses of randomized controlled trials (RCTs) that were available in PubMed from the inception date to November 2022. A consistent beneficial effect of most nuts, namely total nuts and tree nuts, including walnuts, almonds, cashews, peanuts, and pistachios, has been reported across meta-analyses in decreasing total cholesterol (mean difference, MD, −0.09 to −0.28 mmol/L), LDL-cholesterol (MD, −0.09 to −0.26 mmol/L), and triglycerides (MD, −0.05 to −0.17 mmol/L). However, no effects on HDL-cholesterol have been uncovered. Preliminary evidence indicates that adding nuts into the regular diet reduces blood levels of apolipoprotein B and improves HDL function. There is also evidence that nuts dose-dependently improve lipids and lipoproteins. Sex, age, or nut processing are not effect modifiers, while a lower BMI and higher baseline lipid concentrations enhance blood lipid/lipoprotein responses. While research is still emerging, the evidence thus far indicates that nut-enriched diets are associated with a reduced number of total LDL particles and small, dense LDL particles. In conclusion, evidence from clinical trials has shown that the consumption of total and specific nuts improves blood lipid profiles by multiple mechanisms. Future directions in this field should include more lipoprotein particle, apolipoprotein B, and HDL function studies.

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Section: Effects Of Nuts On Blood Lipidsmentioning

confidence: 99%

Section: Effects Of Nuts On Blood Lipidsmentioning

confidence: 99%

Section: Effects Of Nuts On Blood Lipidsmentioning

confidence: 99%

Section: Effects Of Nuts On Blood Lipidsmentioning

confidence: 99%

Section: Effects Of Nuts On Blood Lipidsmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Nut Consumption on Blood Lipids and Lipoproteins: A Comprehensive Literature Update

et al. 2023

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The Cardioprotective Properties of Selected Nuts: Their Functional Ingredients and Molecular Mechanisms

Olas

2024

Foods

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Nuts have been known as a nutritious food since ancient times and can be considered part of our original diet: they are one of the few foods that have been eaten in the same form for thousands of years. They consist of various dry fruits and seeds, with the most common species being almonds (Prunus dulcis), hazelnuts (Corylus avellana), cashews (cashew nuts, Anacardium occidentale), pistachios (Pistacia vera), walnuts (Italian nuts, Juglans regia), peanuts (Arachia hypogaca), Brazil nuts (Bartholletia excels), pecans (Corya illinoinensis), macadamia nuts (Macademia ternifolia) and pine nuts. Both in vitro and in vivo studies have found nuts to possess a range of bioactive compounds with cardioprotective properties, and hence, their consumption may play a role in preventing and treating cardiovascular diseases (CVDs). The present work reviews the current state of knowledge regarding the functional ingredients of various nuts (almonds, Brazil nuts, cashew nuts, hazelnuts, macadamia nuts, peanuts, pecan nuts, pine nuts, pistachios, and walnuts) and the molecular mechanisms of their cardioprotective action. The data indicate that almonds, walnuts and pistachios are the best nut sources of bioactive ingredients with cardioprotective properties.

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Effects of almond consumption on lipid profile in patients with type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials

Cited by 2 publications

References 33 publications

Effects of Nut Consumption on Blood Lipids and Lipoproteins: A Comprehensive Literature Update

Effects of Nut Consumption on Blood Lipids and Lipoproteins: A Comprehensive Literature Update

The Cardioprotective Properties of Selected Nuts: Their Functional Ingredients and Molecular Mechanisms

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