Effects of allopurinol on pain and anxiety in fibromyalgia patients: a pilot study

Fagundes, Aécio C.; Souza, Diogo Onofre Gomes de; Schmidt, André

doi:10.1016/j.bjane.2020.12.016

Cited by 3 publications

(3 citation statements)

References 5 publications

(15 reference statements)

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“…We have demonstrated that allopurinol produced antinociceptive effects in several thermal and chemical pain models in rodents, 33 findings confirmed by another group 34 . In a prospective case series, an add‐on therapy with oral allopurinol 300 mg twice daily caused a significant reduction on pain scores in women with fibromyalgia 59 . More recently, we have shown that oral administration of 2 doses of allopurinol (300 mg) before surgery was associated with a significant reduction in pain scores 2 h after total abdominal hysterectomy in women (data not published).…”

Section: Discussionmentioning

confidence: 93%

“…34 In a prospective case series, an add-on therapy with oral allopurinol 300 mg twice daily caused a significant reduction on pain scores in women with fibromyalgia. 59 More recently, we have shown that oral administration of 2 doses of allopurinol (300 mg) before surgery was associated with a significant reduction in pain scores 2 h after total abdominal hysterectomy in women (data not published). Additionally, our previous findings indicated that only 2 doses of allopurinol (300 mg), in the last 12 h before surgery, caused a significant increase in the cerebrospinal fluid (CSF) levels of xanthine and decreased CSF concentration of uric acid.…”

Section: Discussionmentioning

confidence: 97%

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Allopurinol for fibromyalgia pain in adults: A randomized controlled trial

et al. 2021

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Background: Allopurinol is a potent inhibitor of the enzyme xanthine oxidase used in the treatment of hyperuricemia and gout. Because it is well known that purines exert multiple affects on pain transmission, we hypothesized that the inhibition of xanthine oxidase by allopurinol could be a valid strategy to treat pain in humans.This study aimed to compare the analgesic efficacy of oral allopurinol versus placebo as an adjuvant therapy in patients displaying fibromyalgia.Methods: This randomized, double-blinded, placebo-controlled study included 60 women with the diagnosis of fibromyalgia. Patients were randomly assigned to receive either oral allopurinol 300 mg (n = 31) or placebo (n = 29) twice daily during 30 days. The patients were submitted to evaluation for pain sensitivity, anxiety, depression, and functional status before treatment, and 15 and 30 days thereafter.Results: Oral administration of allopurinol 300 mg twice daily was ineffective in improving pain scores measured by several tools up to 30 days of treatment (P > 0.05).Additionally, no significant effects of allopurinol over anxiety, depressive symptoms, and functional status of fibromyalgia patients were observed in the present study. Conclusions: Although previous findings indicated that allopurinol could present intrinsic analgesic effects in both animals and humans, this study showed no benefit of the use of oral allopurinol as an adjuvant strategy during 30 days in women displaying fibromyalgia. However, considering previous promising results, new prospective studies are still valid to further investigate allopurinol and more selective purine derivatives in the management of pain syndromes. K E Y W O R D S allopurinol, anxiety, depression, fibromyalgia, pain, purines, xanthine oxidase SignificancePrevious evidence has indicated that allopurinol could display some intrinsic analgesic effects and could be an antinociceptive drug against acute and chronic pain syndromes. However, our randomized controlled clinical trial has shown that allopurinol is not effective in the management of fibromyalgia pain and other fibromyalgia-related outcomes, such as anxiety and depression.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Allopurinol for fibromyalgia pain in adults: A randomized controlled trial

et al. 2021

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“…On the other hand, P 2 Y 1 receptors increase by 70% after sciatic nerve injury in rats and may also be related to the development of conditions of pain 34 . The evaluation of the potential of the purinergic system in pain modulation is of great importance and in recent years has received signi- ficant attention in the literature, especially considering that several drugs capable of modulating directly or indirectly the activity of purinergic receptors, such as adenosine, allopurinol, and caffeine, among others, are available for clinical and experimental use 12,[35][36][37][38][39] .…”

Section: The Role Of the Purinergic System In Pain Transmissionmentioning

confidence: 99%

The role of the purinergic system in the acupuncture-induced analgesia

Schmidt¹,

Schmidt²

2021

Brazilian Journal of Pain

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BACKGROUND AND OBJECTIVES: Musculoskeletal disorders and acute and chronic pain are the main causes of disability. Acupuncture is a safe and well-tolerated treatment, and the understanding of the physiological basis of its effectiveness in the management of acute and chronic painful conditions is growing. The objective of this study was to describe the main components of the purinergic system involved in the acupuncture-mediated analgesia. CONTENTS: Review the literature relevant to the terms "acupuncture", "purinergic system", "purines", "pain" and "analgesia" found on the Pubmed platform. CONCLUSION: Several previous studies have shown relevant roles of purines and their derivatives on acupuncture-mediated analgesia, displaying promising results in the knowledge of the potential biological benefits of acupuncture. New experimental and clinical studies are warranted to further investigate the purinergic mechanisms involved in the acupuncture-mediated analgesia, addressing potential therapeutic benefits of acupuncture in different clinical settings.

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Correlação Entre Fibromialgia E Ansiedade: Revisão Sistemática Da Literatura

Pellin,

Back,

Santiago

et al. 2024

Rev. Contemp.

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Além da catastrofização da dor, outras alterações na saúde mental podem agravar a sintomatologia da Fibromialgia, como, por exemplo, Ansiedade e Depressão. Em vista disso, objetivou-se recorrer à revisão de literatura com o objetivo de correlacionar o transtorno de Ansiedade e Fibromialgia e explorar os aspectos subjacentes que ambos os agravos parecem compartilhar. Trata-se de uma revisão sistemática da literatura realizada nas bases de dados LILACS, MEDLINE e SciELO no período de 2017-2023. Foram selecionados 19 estudos, prevalentemente transversais, cujos resultados corroboraram que pacientes com Fibromialgia apresentam uma prevalência significativamente maior de Ansiedade quando comparados aos controles saudáveis, que varia entre 28,75% a 87,50%. As evidências mostram que a dor crônica e a ansiedade se influenciam mutuamente. Foi comprovado que a ansiedade está associada a uma maior gravidade da dor e, por sua vez, níveis mais altos de dor aumenta ou induz níveis mais elevados de Ansiedade, denotando a relação bidirecional. Sugere-se que tais interações correlacionam-se ao funcionamento inadequado do sistema nervoso central devido à Fibromialgia. Além disso, descreve-se que as áreas cerebrais e as vias de neurotransmissores envolvidas na modulação da dor e na ansiedade se sobrepõem.

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Effects of allopurinol on pain and anxiety in fibromyalgia patients: a pilot study

Cited by 3 publications

References 5 publications

Allopurinol for fibromyalgia pain in adults: A randomized controlled trial

Allopurinol for fibromyalgia pain in adults: A randomized controlled trial

The role of the purinergic system in the acupuncture-induced analgesia

Correlação Entre Fibromialgia E Ansiedade: Revisão Sistemática Da Literatura

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