Effects of allantoin on cognitive function and hippocampal neurogenesis

Ahn, Young Je; Park, Se Jin; Woo, Ha Young; Lee, Hyung Eun; Kim, Hyun Ji; Kwon, Guyoung; Gao, Qile; Jang, Dae Sik; Ryu, Jong Hoon

doi:10.1016/j.fct.2013.11.033

Cited by 48 publications

(30 citation statements)

References 31 publications

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“…In agreement with these findings, compounds that positively influence neurogenesis are associated with enhanced performance in hippocampal-dependent learning tasks (Ahn et al 2014;Lee et al 2013a;Snyder et al 2005).…”

Section: Introductionsupporting

confidence: 70%

Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure

Piermartiri

Pan

McDonough³

et al. 2015

Neuromol Med

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Exposure to organophosphorous (OP) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (AChE) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. The hippocampus is profoundly damaged after soman exposure leading to long-term memory deficits. We have previously shown that treatment with three sequential doses of alpha-linolenic acid, an essential omega-3 polyunsaturated fatty acid, increases brain plasticity in naïve animals. However, the effects of this dosing schedule administered after a brain insult and the underlying molecular mechanisms in the hippocampus are unknown. We now show that injection of three sequential doses of alpha-linolenic acid after soman exposure increases the endogenous expression of mature BDNF, activates Akt and the mammalian target of rapamycin complex 1 (mTORC1), increases neurogenesis in the subgranular zone of the dentate gyrus, increases retention latency in the passive avoidance task and increases animal survival. In sharp contrast, while soman exposure also increases mature BDNF, this increase did not activate downstream signaling pathways or neurogenesis. Administration of the inhibitor of mTORC1, rapamycin, blocked the alpha-linolenic acid-induced neurogenesis and the enhanced retention latency but did not affect animal survival. Our results suggest that alpha-linolenic acid induces a long-lasting neurorestorative effect that involves activation of mTORC1 possibly via a BDNF-TrkB-mediated mechanism.

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Section: Introductionsupporting

confidence: 70%

Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure

Piermartiri

Pan

McDonough³

et al. 2015

Neuromol Med

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“…Scientists studied the effects of allantoin on cognitive function and hippocampal neurogenesis & found that allantoin is contained in Nelumbo nucifera & a well-known cosmetic ingredient reported to have anti-oxidative and anti-inflammatory activities. These findings suggest that allantoin has therapeutic potential for the cognitive dysfunctions observed in Alzheimer's disease 12 .…”

Section: Anti-oxidative and Anti-inflammatory Activitymentioning

confidence: 82%

Untitled

2016

IJPSR

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objectives: Nelumbo nucifera Gaertn (Nelumbonaceae) known by numerous common names including Indian lotus, sacred lotus, bean of India, or simply lotus is one of the most important medicinal plants. In this review there is discussion about therapeutic potential of the different parts of the plant (leaves, seeds, flower, and rhizome) which can be used in traditional system of medicine. This review also describes various compounds isolated from different parts of the plant and therapeutic benefits derived from those phytocontituents. The aim of this review is to summarize the pharmacological, phytochemical and therapeutical knowledge of Nelumbo nucifera Gaertn. Key findings: The pharmacological studies have shown that N. nucifera possesses various pharmacological activities like anti-ischemic, antioxidant, anticancer, antiviral, antiobesity, lipolytic, hypocholestemic, antipyretic, hepatoprotective, hypoglycemic, antidiarrhoeal, antifungal, antibacterial, anti-inflammatory and diuretic activities. Several different types of compounds have been derived from this plant belonging to different chemical groups, including alkaloids, flavonoids, glycosides triterpenoid, etc., with own therapeutic impact. So the pharmacological effects and various active ingredients of different parts of N. nucifera are well understood. Summary: This review will facilitate to gain all about the past scientific research and will provide the necessary information about the enormous pharmacological activities of Nelumbo nucifera Gaertn which will insist the researchers for future research to protect human beings from various types of diseases and may serves as a natural gold for the promotion of mankind.

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“…Further, GSK-3␤ inhibition and the Wnt⅐␤-catenin pathway activation through PI3K⅐Akt is very well established (45,48). Therefore, to determine whether ETH induces hippocampal neurogenesis through the PI3K⅐Akt pathway, mRNA expression and phosphorylation of PI3K (Tyr-458) and Akt (Thr-308) were analyzed in an adult hippocampal NSC culture in vitro.…”

Section: Eth Activates the Pi3k⅐akt Signal Transduction Pathway In Admentioning

confidence: 99%

Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway

Tiwari

Seth

Agarwal

et al. 2015

Journal of Biological Chemistry

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Background: Neurogenesis, the process of generation of new neurons, is reduced in Alzheimer disease (AD). Results: Ethosuximide (ETH), an anticonvulsant drug, increased neurogenesis, reduced neurodegeneration, and reversed cognitive impairments in a rat model of AD-like phenotypes. Conclusion: ETH induces neurogenesis, thus reversing AD-like phenotypes. Significance: ETH could be used as a therapeutic molecule to enhance neurogenesis.

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Effects of allantoin on cognitive function and hippocampal neurogenesis

Cited by 48 publications

References 31 publications

Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure

Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure

Untitled

Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway

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