Effects of Alkylating Drugs and Combinations of X-Irradiation and Cortisone on Tumor Immunity

Host‐tumor Antagonism. Xxxvi. Auto‐immune Disease and Cancer: A Correlation of Data on the Lymphocyte, Thymus, Homograft Rejection and Somatic Mutation*

“…When an animal's lymphocytes are destroyed by roentgen irradiation, cortisone or chemotherapeutic agents like nitrogen mustard, a tumor homograft may be accepted by the animal. Preston and co‐workers (12) postulated the deleterious effect of alkylating agents and combinations of x‐irradiation and cortisone on tumor immunity in animals. Pelner has documented the deleterious clinical effect on some localized tumors when patients are given cortisone drugs for a coincidental disorder.…”

Host‐tumor Antagonism. Xxxiii. Cancer Immunity—a Review and an Analysis of Some Factors in Host Resistance to Cancer*

“…When an animal's lymphocytes are destroyed by roentgen irradiation, cortisone or chemotherapeutic agents like nitrogen mustard, a tumor homograft may be accepted by the animal. Preston and co‐workers (56) postulated the deleterious effect of alkylating agents and combinations of x‐irradiation and cortisone on tumor immunity in animals. The present author has documented the deleterious clinical effect on some localized tumors when patients are given cortisone drugs for a coincidental disorder.…”