Effects of alkaloid-rich extract from Mitragyna speciosa (Korth.) Havil. on naloxone-precipitated morphine withdrawal symptoms and local field potential in the nucleus accumbens of mice

Cheaha, Dania; Reakkamnuan, Chayaporn; Nukitram, Jakkrit; Chittrakarn, Somsmorn; Phukpattaranont, Pimpimol; Keawpradub, Niwat; Kumarnsit, Ekkasit

doi:10.1016/j.jep.2017.07.008

Cited by 25 publications

(19 citation statements)

References 45 publications

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“…The mesolimbic pathway, also referred to as the reward pathway, comprises the VTA and the NAc and plays a crucial role in the addictive properties of drugs of abuse, including opioidergic drugs such as morphine. The present findings showed no effect of mitragynine on the regulation of neural oscillations in either the NAc or VTA, consistent with a previous report which showed no effects on NAc oscillatory activity following a very high 80 mg/ kg dose (Cheaha et al, 2017). Acute morphine, on the other hand, induces significant effects on neural oscillatory activity in both of these regions, with acute morphine-induced reductions in theta power and increased gamma power in the NAc (Ahmadi Soleimani et al, 2018;Reakkamnuan et al, 2017), increased power across all frequency bands in the VTA (Ahmadi Soleimani et al, 2018), and increased VTA-NAc coherence in the approximate 20-40 Hz range (Reakkamnuan et al, 2017).…”

Section: Discussionsupporting

confidence: 93%

“…Less is known regarding the effects of mitragynine on neurophysiological systems function, although suppression of cortical low frequency rhythms as measured by electrocorticogram has been described (Yusoff et al, 2016). Another study comparing morphine with kratom extract suggested that while morphine significantly decreased alpha (9.7–12 Hz) and increased low gamma (30.3–44.9 Hz) and high gamma (60.5–95.7 Hz) power in NAc, the kratom extract did not, suggesting potentially non-overlapping mechanisms of action (Cheaha et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Acute mitragynine administration suppresses cortical oscillatory power and systems theta coherence in rats

et al. 2020

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Background: Mitragynine is the major alkaloid of Mitragyna speciosa (kratom) with potential as a therapeutic in pain management and in depression. There has been debate over the potential side effects of the drug including addiction risk and cognitive decline. Aims: To evaluate the effects of mitragynine on neurophysiological systems function in the prefrontal cortex (PFC), cingulate cortex (Cg), orbitofrontal cortex, nucleus accumbens (NAc), hippocampus (HIP), thalamus (THAL), basolateral amygdala (BLA) and ventral tegmental area of rats. Methods: Local field potential recordings were taken from animals at baseline and for 45 min following mitragynine administration (10 mg/kg, intraperitoneally). Drug-induced changes in spectral power and coherence between regions at specific frequencies were evaluated. Mitragynine-induced changes in c-fos expression were also analyzed. Results: Mitragynine increased delta power and reduced theta power in all three cortical regions that were accompanied by increased c-fos expression. A transient suppression of gamma power in PFC and Cg was also evident. There were no effects of mitragynine on spectral power in any of the other regions. Mitragynine induced a widespread reduction in theta coherence (7–9 Hz) that involved disruptions in cortical and NAc connectivity with the BLA, HIP and THAL. Conclusions: These findings show that mitragynine induces frequency-specific changes in cortical neural oscillatory activity that could potentially impact cognitive functioning. However, the absence of drug effects within regions of the mesolimbic pathway may suggest either a lack of addiction potential, or an underlying mechanism of addiction that is distinct from other opioid analgesic agents.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Acute mitragynine administration suppresses cortical oscillatory power and systems theta coherence in rats

et al. 2020

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“…The effect of medicinal plants to improve symptoms of morphine dependence has been studied. It has been reported that some medicinal plants, such as Mitragyna speciosa and Matricaria chamomilla , have been shown to relieve morphine withdrawal symptoms in rats [ 23 , 24 ]. However, no study has been published in scientific journals that investigated the effects of PFE on morphine withdrawal syndrome in rats.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats

Moayeri

Azimi

Karimi

et al. 2018

Med Sci Monit Basic Res

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BackgroundToday, the plant Prosopis farcta is frequently used for traditional medicinal purposes. The aim of this study was the identification of luteolin in P. farcta extract (PFE) and to evaluate its effect on morphine discontinuation syndrome in rats.Material/MethodsUsing high-performance liquid chromatography (HPCL), luteolin was evaluated in PFE. The frequency of behavioral symptoms of morphine withdrawal (jumping, rearing, and teeth chattering) induced by naloxone challenge were illustrated in morphine-dependent rats receiving PFE, luteolin, saline, or clonidine. LD50 of PFE and luteolin was 540 mg/kg and 150 mg/kg, respectively. Signs of behavioral morphine withdrawal in rats were significantly inhibited by chronic co-administration of PFE, luteolin, or clonidine with morphine.ResultsThis study showed that PFE was less effective than clonidine at a dose of 100 mg/kg, and at doses of 200 mg/kg and 300 mg/kg it was comparable to clonidine, and did not show a significant difference in the reduction of morphine withdrawal symptoms. Luteolin was comparable in 30 mg/kg, 60 mg/kg, and 90 mg/kg with clonidine to reduce the frequency of morphine withdrawal symptoms. PFE can be used as a source of luteolin.ConclusionsThe study findings suggest that PFE and luteolin might reduce the signs of narcotic withdrawal. Due to a similar effect to clonidine, its mechanism of action might be through the protein kinase A pathway and might have human therapeutic potential.

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“…Depending on the experimenter's timeline, sensitization can be rapidly induced to study the shortterm drug-induced changes and/or long-term effects of chronic drug exposure. The development of behavioral sensitization has been hypothesized to represent a transition from drug "liking" to "wanting" that underlies compulsive substance use as reported to occur in response to morphine (Cheaha et al, 2017), amphetamine (Ridzwan et al, 2017), alcohol (Mitra and Nagaraja, 2020), nicotine, cocaine, and cannabinoids (Steketee and Kalivas, 2011;Venniro et al, 2016;Iman et al, 2017;Müller, 2018;Kuhn et al, 2019).…”

Section: Behavioral Sensitizationmentioning

confidence: 99%

The IntelliCage System: A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder

Iman

Yusof

Talib

et al. 2021

Front. Behav. Neurosci.

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The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.

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Effects of alkaloid-rich extract from Mitragyna speciosa (Korth.) Havil. on naloxone-precipitated morphine withdrawal symptoms and local field potential in the nucleus accumbens of mice

Cited by 25 publications

References 45 publications

Acute mitragynine administration suppresses cortical oscillatory power and systems theta coherence in rats

Acute mitragynine administration suppresses cortical oscillatory power and systems theta coherence in rats

Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats

The IntelliCage System: A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder

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